Zobrazeno 1 - 10
of 42
pro vyhledávání: '"J M Besterman"'
Autor:
Daniel J. Diekema, J. M. Besterman, Shawn A. Messer, L. A. Martell, N. Georgopapadakou, M. A. Pfaller
Publikováno v:
Journal of Clinical Microbiology. 47:3797-3804
We report on the in vitro activity of the Hos2 fungal histone deacetylase (HDAC) inhibitor MGCD290 (MethylGene, Inc.) in combination with azoles against azole-resistant yeasts and molds. Susceptibility testing was performed by the CLSI M27-A3 and M38
Autor:
Wilson H. Miller, Marja Dubay, Tracy Patterson, Zeev Estrov, Zuomei Li, Caroline Rousseau, Eric Laille, Gregory K. Reid, Guillermo Garcia-Manero, Sarit Assouline, Robert E. Martell, Ann Kalita, Willie Newsome, Claire Bonfils, H. Yang, Hagop M. Kantarjian, Jorge E. Cortes, Mark D. Minden, J. M. Besterman
Publikováno v:
Blood. 112:981-989
MGCD0103 is an isotype-selective inhibitor of histone deacetylases (HDACs) targeted to isoforms 1, 2, 3, and 11. In a phase 1 study in patients with leukemia or myelodysplastic syndromes (MDS), MGCD0103 was administered orally 3 times weekly without
Autor:
M. Maclean, Nisha Mistry, J. M. Besterman, Debbie Ayers, Susan D'Aloisio, Carolyn D. Britten, Nancy Wainman, Elizabeth Eisenhauer, Henry Klamut, Malcolm J. Moore, Patricia S. Firby, Lillian L. Siu, Alison Davis, Karen A. Gelmon, Gregory K. Reid
Publikováno v:
Investigational New Drugs. 21:85-97
Purpose: MG98 is a second generation phosphorothioate antisense oligodeoxynucleotide which is a highly specific inhibitor of translation of the mRNA for human DNA MeTase I (DNMT 1). This phase I study examined the toxicity and pharmacologic profile o
Autor:
Geoffrey A. Cordell, Philippe Rasoanaivo, J. M. Pezzuto, Monks A, Jane Lewis, Baoliang Cui, Gloria L. Silva, Melanie J. O'Neill, Norman R. Farnsworth, A. D. Kinghorn, Sean M. Lynn, HB Chai, Min You, Daniel Chávez, J M Besterman
Publikováno v:
Journal of Natural Products. 64:1514-1520
Nine tropane alkaloid aromatic esters (1−9) were isolated from the roots of Erythroxylum pervillei by following their potential to reverse multidrug-resistance with vinblastine-resistant oral epidermoid carcinoma (KB-V1) cells. All isolates, includ
Lupane Derivatives from Lophopetalum wallichii with Farnesyl Protein Transferase Inhibitory Activity
Autor:
J. A. Lewis, John M. Pezzuto, T. Santisuk, R M Tait, A Howe, Roberto R. Gil, Olipa Ngassapa, Vichai Reutrakul, Norman R. Farnsworth, Shu-Wei Yang, J M Besterman, M J O'Neill, Heebyung Chai, J E Farthing, S Sturm, A. D. Kinghorn, M Moss, Geoffrey A. Cordell
Publikováno v:
Journal of Natural Products. 59:658-663
Chloroform-soluble extracts of the stems and of the mixed stems and stem bark of Lophopetalum wallichii were found to be inhibitory in a farnesyl protein transferase (FPTase) bioassay system. During the course of activity-guided fractionation, the kn
Autor:
J. M. Besterman, M. B. Moyer, Y.-C. J. Wang, William Ramos, Zachary B. Mackey, I. Husain, Alan E. Tomkinson, W. A. Burkhart, Jingwen Chen
Publikováno v:
Journal of Biological Chemistry. 269:31923-31928
Mammalian cells contain three biochemically distinct DNA ligases. In this report we describe the purification of DNA ligase II to homogeneity from bovine liver nuclei. This enzyme interacts with ATP to form an enzyme-AMP complex, in which the AMP moi
Autor:
Yuan Ji, J. M. Besterman, Zuomei Li, Tracy Patterson, Michel Drouin, M. Renee Ward, John Kuruvilla, Yasuhiro Oki, Daniela Buglio, R Gregory Bociek, Robert E. Martell, L. Jeffrey Medeiros, Anas Younes, Michelle A. Fanale, Jessica K. Paulus, Ahmed Galal, Amanda Copeland, Sattva S. Neelapu
Publikováno v:
The Lancet. Oncology. 12(13)
Summary Background The prognosis of patients with relapsed Hodgkin's lymphoma, especially those who relapse after stem-cell transplantation, is poor, and the development of new agents for this patient population is an unmet medical need. We tested th
Publikováno v:
Journal of Biological Chemistry. 267:842-847
Prior studies demonstrated that ceramide was phosphorylated by a novel Ca(2+)-dependent kinase distinct from diacylglycerol (DG) kinase in human myelogenous leukemia (HL-60) cells (Kolesnick, R. N., and Hemer, M. R. (1990) J. Biol. Chem. 265, 10900-1
Autor:
Lillian L. Siu, Ann Kalita, Gregory K. Reid, Robert E. Martell, Marja Dubay, Zuomei Li, J. M. Besterman, Michael A. Carducci, Claire Bonfils
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 14(11)
Purpose: The pharmacodynamic properties of MGCD0103, an isotype-selective inhibitor of histone deacetylase (HDAC), were evaluated in preclinical models and patients with a novel whole-cell HDAC enzyme assay. Experimental Design: Boc-Lys(ε-Ac)-AMC, a
Autor:
Eric Laille, J. M. Besterman, M. Maclean, Roberto Pili, Michael A. Carducci, Robert E. Martell, Ann Kalita, Wells A. Messersmith, Eric X. Chen, Zuomei Li, Shirley Brown, Rana Sullivan, Serina King, Gregory K. Reid, Lillian L. Siu, Ignacio Duran
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 26(12)
Purpose MGCD0103 is a novel isotype-selective inhibitor of human histone deaceylases (HDACs) with the potential to regulate aberrant gene expression and restore normal growth control in malignancies. Patients and Methods A phase I trial of MGCD0103,