In vivo imaging of brain microglial activity in antipsychotic-free and medicated schizophrenia: a [11C](R)-PK11195 positron emission tomography study

Autor: Richard Drake, J M Anton-Rodriguez, Silke Conen, C J Gregory, Alexander Gerhard, Rainer Hinz, J C Matthews, Peter S. Talbot, Sophie E. Holmes

Publikováno v: Holmes, S, Hinz, R, Drake, R, Gregory, C, Conen, S, Matthews, J, Anton-Rodriguez, J, Gerhard, D A & Talbot, P 2016, ' In-vivo imaging of brain microglial activity in antipsychotic-free and medicated schizophrenia: a [ 11 C] (R)-PK11195 positron emission tomography study ', Molecular psychiatry, vol. 21, no. 12, pp. 1672-1679 . https://doi.org/10.1038/mp.2016.180

Positron emission tomography (PET) imaging of the 18kDa translocator protein (TSPO) has been used to investigate whether microglial activation, an indication of neuroinflammation, is evident in the brain of adults with schizophrenia. Interpretation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6032dbea5d8e8865758d62496f41a5a
https://doi.org/10.1038/mp.2016.180

Optimization of methods for quantification of rCBF using high-resolution [¹⁵O]H₂O PET images

Autor: M D, Walker, M, Feldmann, J C, Matthews, J M, Anton-Rodriguez, S, Wang, M J, Koepp, M-C, Asselin

Publikováno v: Physics in medicine and biology. 57(8)

This study aimed to derive accurate estimates of regional cerebral blood flow (rCBF) from noisy dynamic [¹⁵O]H₂O PET images acquired on the high-resolution research tomograph, while retaining as much as possible the high spatial resolution of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0858d0408f975c43ef137457b8321620
https://pubmed.ncbi.nlm.nih.gov/22455998