Zobrazeno 1 - 10
of 16
pro vyhledávání: '"J M, Zgombick"'
Autor:
Richard L. Weinshank, S A Kucharewicz, J M Zgombick, Theresa A. Branchek, D.A Urquhart, J. A. Bard
Publikováno v:
Neuropharmacology. 36:513-524
Human 5-HT1B and 5-HT1D receptors have been implicated as molecular targets for the treatment of acute migraine based upon the pharmacological actions and clinical efficacy of sumatriptan, an agonist for human 5-HT1B/1D receptors. The guinea pig has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6481d75833c77ab2501f19583144dbf6
https://doi.org/10.1016/s0028-3908(97)00023-3
https://doi.org/10.1016/s0028-3908(97)00023-3
Autor:
J. A. Bard, Richard L. Weinshank, N. Adham, Theresa A. Branchek, S A Kucharewicz, J M Zgombick, Margaret M. Durkin
Publikováno v:
Neuropharmacology. 36:569-576
The anti-migraine compound, sumatriptan, has been shown to have substantial affinity for the cloned human 5-HT1F receptor suggesting that, in addition to 5-HT1B/5-HT1D receptor subtypes, the 5-HT1F receptor may be a therapeutic target for the treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b668c57687a3abca13adadff10f96ad3
https://doi.org/10.1016/s0028-3908(97)00020-8
https://doi.org/10.1016/s0028-3908(97)00020-8
Autor:
K, Rasmussen, D O, Calligaro, J F, Czachura, L J, Dreshfield-Ahmad, D C, Evans, S K, Hemrick-Luecke, M J, Kallman, W T, Kendrick, J D, Leander, D L, Nelson, C D, Overshiner, D B, Wainscott, M C, Wolff, D T, Wong, T A, Branchek, J M, Zgombick, Y C, Xu
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 294(2)
LY426965 [(2S)-(+)-1-cyclohexyl-4-[4-(2-methoxyphenyl)-1-piperazinyl]2-methyl- 2-phenyl-1-butanone monohydrochloride] is a novel compound with high affinity for the cloned human 5-hydroxytryptamine (HT)(1A) receptor (K(i) = 4.66 nM) and 20-fold or gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::764fb6e2b02cfb840ab821357478eae6
https://pubmed.ncbi.nlm.nih.gov/10900249
https://pubmed.ncbi.nlm.nih.gov/10900249
Autor:
T. A. Branchek, J. M. Zgombick
Publikováno v:
Serotoninergic Neurons and 5-HT Receptors in the CNS ISBN: 9783540667155
The supposition that multiple receptor subtypes mediate the numerous physiological actions of 5-HT has been elegantly substantiated by molecular cloning, including the discovery of “novel” receptor subtypes such as 5-HT5A, 5-HT5B, 5-HT6, and 5-HT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6a09d1bce984e6689a7e3fa25bae9ec
https://doi.org/10.1007/978-3-642-60921-3_18
https://doi.org/10.1007/978-3-642-60921-3_18
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 287(3)
[3H]5-HT revealed the presence of serotonin receptors in cultured rat sensory neurons. [3H]5-CT binding was inhibited by cyanopindolol with an IC50 of 0.87 +/- 0.30 nM, suggesting the expression of the 5-HT1B receptor in these neurons. The presence o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d00785ddce4db828d425a9874c3c91fa
https://pubmed.ncbi.nlm.nih.gov/9864301
https://pubmed.ncbi.nlm.nih.gov/9864301
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 287(2)
Functional characterization of the recombinant human 5-hydroxytryptamine7(a) (h5-HT7(a)) receptor isoform was performed using stably transfected LM(tk-) cells. Expression levels of the h5-HT7(a) receptor determined from saturation studies using eithe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c772e2cc6cc6d7f0e1928ff048edc7a6
https://pubmed.ncbi.nlm.nih.gov/9808674
https://pubmed.ncbi.nlm.nih.gov/9808674
Publikováno v:
Neuropharmacology. 36(4-5)
Human 5-HT1B and 5-HT1D receptors have been implicated as molecular targets for the treatment of acute migraine based upon the pharmacological actions and clinical efficacy of sumatriptan, an agonist for human 5-HT1B/1D receptors. The guinea pig has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7a3b275bc8a4ee2508f4b4ee64181f9f
https://pubmed.ncbi.nlm.nih.gov/9225276
https://pubmed.ncbi.nlm.nih.gov/9225276
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 354(3)
Recombinant human 5-HT1D alpha and 5-HT1D beta receptor subtypes were stably expressed in NIH-3T3 fibroblasts (1D alpha cell line) and Y-1 adrenocortical tumor cells (1D beta cell line), respectively, for pharmacological evaluations of serotonergic c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b5a770a8a4d696656dd7f3684ceaefdd
https://pubmed.ncbi.nlm.nih.gov/8878051
https://pubmed.ncbi.nlm.nih.gov/8878051
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 277(3)
The canine coronary artery possesses a smooth muscle relaxant serotonin (5-HT) receptor distinct from previously characterized 5-HT receptors. On the basis of the ability of LY53857 to block weakly coronary smooth muscle relaxation to 5-HT, we examin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::89044e880be11ecb6e77339b5bdc164c
https://pubmed.ncbi.nlm.nih.gov/8667223
https://pubmed.ncbi.nlm.nih.gov/8667223
Publikováno v:
Molecular pharmacology. 44(3)
The second messenger coupling of cloned human 5-hydroxytryptamine (5-HT)1D alpha and 5-HT1D beta receptors stably expressed in murine fibroblasts (LM (tk-)) was investigated. Clonal cell lines expressing similar receptor densities (Bmax = 750-950 fmo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ace775f7f95e421e8a66e14fd590b3bf
https://pubmed.ncbi.nlm.nih.gov/8396718
https://pubmed.ncbi.nlm.nih.gov/8396718