Výsledky vyhledávání - "J M, Woynarowski"

WP744, a novel anthracycline with enhanced proapoptotic and antileukemic activity

Autor: S, Faderl, Z, Estrov, H M, Kantarjian, D, Harris, Q, Van, I, Fokt, T, Przewloka, C, Godlewski, J M, Woynarowski, W, Priebe

Publikováno v: Anticancer research. 21(6A)

MDR1 or MRP1 drug resistance mechanisms seriously limit the efficacy of anthracyclines such as doxorubicin, in the treatment of acute myeloid leukemia (AML). Our studies indicated that reducing basicity, increasing steric hindrance at C-4', and/or li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b833d6cb3cbbf2cd4742fff7f957e808
https://pubmed.ncbi.nlm.nih.gov/11911247

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7- and 10-substituted camptothecins: dependence of topoisomerase I-DNA cleavable complex formation and stability on the 7- and 10-substituents

Autor: B, Vladu, J M, Woynarowski, G, Manikumar, M C, Wani, M E, Wall, D D, Von Hoff, R M, Wadkins

Publikováno v: Molecular pharmacology. 57(2)

7-Alkyl, 7-alkyl-10-hydroxy, 7-alkyl-10-methoxy, and 7-alkyl-10, 11-methylenedioxy analogs of camptothecin have been synthesized and evaluated for their ability to trap human DNA topoisomerase I in cleavable complexes. The 7-alkyl chain lengths varie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a6771102b1ce09857abf6022613c7be0
https://pubmed.ncbi.nlm.nih.gov/10648633

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Oxaliplatin: mechanism of action and antineoplastic activity

Autor: E, Raymond, S, Faivre, J M, Woynarowski, S G, Chaney

Publikováno v: Seminars in oncology. 25(2 Suppl 5)

Oxaliplatin, a platinum-based chemotherapeutic agent with a 1,2-diaminocyclohexane (DACH) carrier ligand, has shown in vitro and in vivo efficacy against many tumor cell lines, including some that are resistant to cisplatin and carboplatin. The reten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::94b967dd4378be7a1f90d5449a866976
https://pubmed.ncbi.nlm.nih.gov/9609103

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Topoisomerase II mediated DNA lesions induced by acridine-4-carboxamide and 2-(4-pyridyl)quinoline-8-carboxamide

Autor: J M, Woynarowski, K, McCarthy, B, Reynolds, T A, Beerman, W A, Denny

Publikováno v: Anti-cancer drug design. 9(1)

Acridine-4-carboxamide and 2-(4-pyridyl)quinoline-8-carboxamide represent a new generation of antitumor intercalators related to amsacrine (m-AMSA), a classic topoisomerase II-targeted drug. We examined the ability of these tricyclic carboxamides to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::80f590bfb3716bff1c8cafcbe07d330e
https://pubmed.ncbi.nlm.nih.gov/8141968

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Effects of ledakrin on DNA and cell cycle in HeLa S3 cells

Autor: J M, Woynarowski, J, Konopa

Publikováno v: Drugs under experimental and clinical research. 12(6-7)

An antitumour DNA cross-linking drug, ledakrin, and other antitumour 1-nitro-9-aminoacridines applied to HeLa S3 cells caused a preferential accumulation of cells in S phase, as found by the flow cytometry technique. At lower drug levels, this effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dd958adeee9a141b96be634df86dcfd7
https://pubmed.ncbi.nlm.nih.gov/3743369

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Modulation of topoisomerase II catalytic activity by DNA minor groove binding agents distamycin, Hoechst 33258, and 4',6-diamidine-2-phenylindole

Autor: J M, Woynarowski, M, McHugh, R D, Sigmund, T A, Beerman

Publikováno v: Molecular pharmacology. 35(2)

The effects of distamycin, Hoechst 33258, and 4',6-diamidine-2-phenylindole (DAPI) on the catalytic activity of topoisomerase II from L1210 cells were determined. These compounds were used as model agents capable of AT-specific binding in the minor g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3587307765a4f921262dea2a807e2c92
https://pubmed.ncbi.nlm.nih.gov/2465485

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Inhibition of DNA replication in HeLa S3 cells by macromomycin-I, an antitumor protein antibiotic

Autor: J M, Woynarowski, T A, Beerman

Publikováno v: Molecular pharmacology. 18(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4b23d43509f34666f9ab755a2d449329
https://pubmed.ncbi.nlm.nih.gov/7464814

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Studies on the mechanism of antitumour activity of Ledakrin

Autor: J, Konopa, E, Chotkowska, K, Koldej, A, Matuszkiewicz, J W, Pawlak, J M, Woynarowski

Publikováno v: Materia medica Polona. Polish journal of medicine and pharmacy. 8(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fcac8b0dc99c5cc9b9da4e8030444aa8
https://pubmed.ncbi.nlm.nih.gov/1011867

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Neurotensin receptor-mediated inhibition of pancreatic cancer cell growth by the neurotensin antagonist SR 48692

Autor: M C, Herzig, W G, Chapman, A, Sheridan, J B, Rake, J M, Woynarowski

Publikováno v: Europe PubMed Central

Second messenger calcium responses to the neuropeptide neurotensin and its non-peptide antagonist SR 48692 were studied in relation to the proliferation of pancreatic cancer cells. Neurotensin caused a transient increase in intracellular calcium in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a0ef7f95558252c2ac940849b710d776
http://europepmc.org/abstract/med/10226545

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