A miR-375/YAP axis regulates neuroendocrine differentiation and tumorigenesis in lung carcinoid cells

Autor: Xiaojing Yang, Jina Nanayakkara, Duncan Claypool, Sadegh Saghafinia, Justin J. M. Wong, Minqi Xu, Xiantao Wang, Christopher J. B. Nicol, Iacovos P. Michael, Markus Hafner, Xiaolong Yang, Neil Renwick

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Abstract Lung carcinoids are variably aggressive and mechanistically understudied neuroendocrine neoplasms (NENs). Here, we identified and elucidated the function of a miR-375/yes-associated protein (YAP) axis in lung carcinoid (H727) cells. miR-375

Externí odkaz: https://doaj.org/article/72661e3a38244d87bdf71ce5806af456

Executive Summary: International Clinical Practice Guidelines for Pediatric Ventilator Liberation, A Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network Document

Autor: Samer Abu-Sultaneh, Narayan Prabhu Iyer, Analía Fernández, Michael Gaies, Sebastián González-Dambrauskas, Justin Christian Hotz, Martin C. J. Kneyber, Yolanda M. López-Fernández, Alexandre T. Rotta, David K. Werho, Arun Kumar Baranwal, Bronagh Blackwood, Hannah J. Craven, Martha A. Q. Curley, Sandrine Essouri, Jose Roberto Fioretto, Silvia M. M. Hartmann, Philippe Jouvet, Steven Kwasi Korang, Gerrard F. Rafferty, Padmanabhan Ramnarayan, Louise Rose, Lyvonne N. Tume, Elizabeth C. Whipple, Judith J. M. Wong, Guillaume Emeriaud, Christopher W. Mastropietro, Natalie Napolitano, Christopher J. L. Newth, Robinder G. Khemani

Publikováno v: Rose, L 2023, ' Executive Summary: International Clinical Practice Guidelines for Pediatric Ventilator Liberation, A Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network Document ', American Journal of Respiratory and Critical Care Medicine, vol. 207, no. 1, pp. 17-28 . https://doi.org/10.1164/rccm.202204-0795SO
Abu-Sultaneh, S, Iyer, N P, Fernández, A, Gaies, M, González-Dambrauskas, S, Hotz, J C, Kneyber, M C J, López-Fernández, Y M, Rotta, A T, Werho, D K, Baranwal, A K, Blackwood, B, Craven, H J, Curley, M A Q, Essouri, S, Fioretto, J R, Hartmann, S M M, Jouvet, P, Korang, S K, Rafferty, G F, Ramnarayan, P, Rose, L, Tume, L N, Whipple, E C, Wong, J J M, Emeriaud, G, Mastropietro, C W, Napolitano, N, Newth, C J L & Khemani, R G 2023, ' Executive summary: International clinical practice guidelines for pediatric ventilator liberation, a pediatric acute lung injury and sepsis investigators (PALISI) network document ', American Journal of Respiratory and Critical Care Medicine, vol. 207, no. 1, pp. 17-28 . https://doi.org/10.1164/rccm.202204-0795SO

RATIONALE: Pediatric specific ventilator liberation guidelines are lacking despite the many studies exploring elements of extubation readiness testing. The lack of clinical practice guidelines has led to significant and unnecessary variation in metho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dfca1cd5fd69a12d9f5ff0c9fe698f4
https://pubmed.ncbi.nlm.nih.gov/36067508

Unique mechanistic insights into pathways associated with the synergistic activity of polymyxin B and caspofungin against multidrug-resistant

Autor: Maytham, Hussein, Labell J M, Wong, Jinxin, Zhao, Vanessa E, Rees, Rafah, Allobawi, Rajnikant, Sharma, Gauri G, Rao, Mark, Baker, Jian, Li, Tony, Velkov

Publikováno v: Computational and structural biotechnology journal. 20

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::24a7dac6987c244451ff79ff3e95b3e1
https://pubmed.ncbi.nlm.nih.gov/35284046

Characterizing and classifying neuroendocrine neoplasms through microRNA sequencing and data mining

Autor: Thomas Tuschl, Michelle K. Kim, Paula S. Ginter, Pavel Morozov, Simron Singh, Kaitlin Vanderbeck, Iddo Z. Ben-Dov, Theresa Scognamiglio, Nai-Kong V. Cheung, Yao-Tseng Chen, Klaas E. A. Max, Frederike Dijk, Xiaojing Yang, Justin J M Wong, Jina Nanayakkara, Kathrin Tyryshkin, Neil Renwick, Nicole C. Panarelli

Publikováno v: NAR cancer, 2(3)
Nar Cancer

Neuroendocrine neoplasms (NENs) are clinically diverse and incompletely characterized cancers that are challenging to classify. MicroRNAs (miRNAs) are small regulatory RNAs that can be used to classify cancers. Recently, a morphology-based classifica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::128375719c104c9f39e44457ea382fba
http://www.scopus.com/inward/record.url?scp=85099341563&partnerID=8YFLogxK

Bioequivalence and pharmacokinetic comparison of two fixed dose combination of Metformin/ Glibenclamide formulations in healthy subjects under fed condition

Autor: C T, Chang, J Y, Ang, J M, Wong, S S, Tan, S K, Chin, A B, Lim, W H, Tan, K H, Yuen

Publikováno v: The Medical journal of Malaysia. 75(3)

This study is conducted to compare the pharmacokinetic profiles of two fixed dose combination of metformin/glibenclamide tablets (500mg/5 mg per tablet).This is a single-center, single-dose, open-label, randomized, 2-treatment, 2-sequence and 2- peri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0a29f64e9625e3a8d52d56267bb69ee9
https://pubmed.ncbi.nlm.nih.gov/32467546