Zobrazeno 1 - 10
of 43
pro vyhledávání: '"J M, Witkin"'
Autor:
A, Biggerstaff, B, Kivell, J L, Smith, Md Y, Mian, L K, Golani, F, Rashid, D, Sharmin, D E, Knutson, R, Cerne, J M, Cook, J M, Witkin
Publikováno v:
Pharmacology, biochemistry, and behavior. 196
Opiate analgesics are one of the treatment options for severe chronic pain, including late-stage cancer, chronic back pain and other disorders. The recent resurgence in opioid overdose has highlighted the serious need for alternative medicines for pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::12d6e0bd24c3ec16ab532139066bc8ee
https://pubmed.ncbi.nlm.nih.gov/32668266
https://pubmed.ncbi.nlm.nih.gov/32668266
Publikováno v:
Pharmacology, biochemistry, and behavior. 194
Substance abuse disorder continues to have devastating consequences for individuals and society and current therapies are not sufficient to provide the magnitude of medical impact required. Although some evidence suggests the use of ketamine in treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::894ec80e82775545e76ae4a1635d6903
https://pubmed.ncbi.nlm.nih.gov/32333922
https://pubmed.ncbi.nlm.nih.gov/32333922
Autor:
J M, Witkin, J L, Smith, X, Ping, S D, Gleason, M M, Poe, G, Li, X, Jin, J, Hobbs, J M, Schkeryantz, J S, McDermott, A I, Alatorre, J N, Siemian, J W, Cramer, D C, Airey, K R, Methuku, V V N P B, Tiruveedhula, T M, Jones, J, Crawford, M J, Krambis, J L, Fisher, J M, Cook, R, Cerne
Publikováno v:
Neuropharmacology. 137
HZ-166 has previously been characterized as an α2,3-selective GABA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5acaac2430fa7e90d14baaa5c70b7b8f
https://pubmed.ncbi.nlm.nih.gov/29778948
https://pubmed.ncbi.nlm.nih.gov/29778948
Autor:
J M, Witkin, S N, Mitchell, K A, Wafford, G, Carter, G, Gilmour, J, Li, B J, Eastwood, C, Overshiner, X, Li, L, Rorick-Kehn, K, Rasmussen, W H, Anderson, A, Nikolayev, V V, Tolstikov, M-S, Kuo, J T, Catlow, R, Li, S C, Smith, C H, Mitch, P L, Ornstein, S, Swanson, J A, Monn
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 361(1)
The ability of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e8d8a306d81ab2f41cb8a98681e9243c
https://pubmed.ncbi.nlm.nih.gov/28138040
https://pubmed.ncbi.nlm.nih.gov/28138040
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4bafef0a3e799251f37bab3bcc7b99e
https://doi.org/10.1002/chin.199446188
https://doi.org/10.1002/chin.199446188
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 326(3)
Previous findings have demonstrated a protective role for dopamine D(3)/D(2) receptor agonists in the convulsant and lethal effects of acutely administered cocaine. Data are provided here to establish that the protection occurs through a D(3)-linked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5d59a96fc5d26c7fe39305538beb3caa
https://pubmed.ncbi.nlm.nih.gov/18566292
https://pubmed.ncbi.nlm.nih.gov/18566292
Autor:
D K, Miller, P A, Crooks, L, Teng, J M, Witkin, P, Munzar, S R, Goldberg, J B, Acri, L P, Dwoskin
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 296(3)
Lobeline interacts with the dopamine transporter and vesicular monoamine transporter, presynaptic proteins involved in dopamine storage and release. This study used rodent models to assess lobeline-induced inhibition of the neurochemical and behavior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::868b6b07f96eb728125fe3891e78f57f
https://pubmed.ncbi.nlm.nih.gov/11181937
https://pubmed.ncbi.nlm.nih.gov/11181937
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 295(1)
Chlormethiazole positively modulates the gamma-aminobutyric acid (GABA)(A) receptor complex and is primarily used to treat certain life-threatening neurological events (e.g., refractory seizures and ethanol withdrawal syndrome). On account of several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8981c0705542ded0c9960be57e3b2474
https://pubmed.ncbi.nlm.nih.gov/10991973
https://pubmed.ncbi.nlm.nih.gov/10991973
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 290(3)
Seizures and status epilepticus are among the neurological complications of cocaine overdose in humans. The aim of the present study was to evaluate the protective effectiveness and therapeutic index (separation between anticonvulsive and side effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::14cdbfa8612567dbd775a06caee8f55a
https://pubmed.ncbi.nlm.nih.gov/10454489
https://pubmed.ncbi.nlm.nih.gov/10454489
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 289(2)
Convulsions associated with cocaine abuse can be life threatening and resistant to standard emergency treatment. Cocaine (75 mg/kg, i. p.) produced clonic convulsions in approximately 90% of male, Swiss-Webster mice. A variety of clinically used anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1924c59db4367695dbf160cba44e8a60
https://pubmed.ncbi.nlm.nih.gov/10215643
https://pubmed.ncbi.nlm.nih.gov/10215643