Determinants of red blood cell deformability in relation to cell age

Autor: Bregt Roerdinkholder-Stoelwinder, Frans L A Willekens, F H Bosch, M R Halie, T H Huls, L Schipper, G Wichers, J. M. Werre

Publikováno v: European Journal of Haematology. 52:35-41

Red blood cell (RBC) deformability was determined with an ektacytometer in fractions separated on the basis of differences in cell volume or density. Deformability was measured with ektacytometry (rpm-scan and osmo-scan). We studied three groups of R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0159c75293a8928a20183d63c9ec14a4
https://doi.org/10.1111/j.1600-0609.1994.tb01282.x

Erythrocyte ageingin vivoandin vitro: structural aspects and implications for transfusion

Autor: Frans L A Willekens, Giel J. C. G. M. Bosman, V. M. J. Novotný, J. M. Werre

Publikováno v: Transfusion Medicine, 18, 335-347
Transfusion Medicine, 18, 6, pp. 335-347
Transfusion Medicine, 18, 335-47
Transfusion Medicine, 18, 6, pp. 335-47

Contains fulltext : 70373.pdf (Publisher’s version ) (Closed access) Erythrocyte transfusion is essential in conditions of large blood loss, of inadequate bone marrow production and of increased erythrocyte breakdown. The structural and biochemical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32e6de42566583acc266f25ba4bd6d91
https://doi.org/10.1111/j.1365-3148.2008.00892.x

Feasibility of a new in vitro approach to evaluate cellular damage following co-infusion of red blood cell concentrates and intravenous drug solutions

Autor: B.E. de Pauw, W.J.M. Wissink, A.V.M.B. Schattenberg, J. M. Werre, A.G. van den Bos

Publikováno v: Clinical & Laboratory Haematology. 25:173-178

SummaryIntroduction: Transfusion guidelines may result in unwanted delay in infusion schemes, as simultaneous infusion of blood components and drug solutions is universally prohibited. The aim of this study was to measure possible damage to red cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f3076583415232b59c01c45907187fc
https://doi.org/10.1046/j.1365-2257.2003.00495.x

Comparative proteomics of erythrocyte aging in vivo and in vitro

Autor: Frans L A Willekens, Edwin Lasonder, J. M. Werre, V. M. J. Novotný, Giel J. C. G. M. Bosman, Yvonne A.M. Groenen-Döpp

Publikováno v: Journal of Proteomics, 73, 396-402
Journal of Proteomics, 73, 3, pp. 396-402

Contains fulltext : 89623.pdf (Publisher’s version ) (Closed access) During aging in vivo and in vitro, erythrocytes display removal signals. Phagocytosis is triggered by binding of autologous IgG to a senescent cell antigen originating on band 3.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba2468e6356a042ba8f140019f5c590
https://doi.org/10.1016/j.jprot.2009.07.010

Liver Kupffer cells rapidly remove red blood cell-derived vesicles from the circulation by scavenger receptors

Autor: J. Kar Kruijt, G.J.C.G.M. Bosman, Theo J.C. Van Berkel, Frans L A Willekens, Bregt Roerdinkholder-Stoelwinder, Annegeet G. van den Bos, J. M. Werre, Yvonne A.M. Groenen-Döpp

Publikováno v: Blood, 105, 2141-5
Blood, 105, 5, pp. 2141-5

Previous studies have shown that during the lifespan of red blood cells (RBCs) 20% of hemoglobin is lost by shedding of hemoglobin-containing vesicles. However, the fate of these vesicles is unknown. To study this fate we used a rat model, after havi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b465c01f65052266efcd90635ffa9c6e
http://hdl.handle.net/2066/47499