Výsledky vyhledávání

Developmental differences in place-learning performance between C57BL/6 and DBA/2 mice parallel the ontogeny of hippocampal protein kinase C

Autor: R, Paylor, L, Baskall-Baldini, L, Yuva, J M, Wehner

Publikováno v: Behavioral Neuroscience. 110:1415-1425

This study determined the ontogenic changes in learning and hippocampal protein kinase C (PKC) in C57 and DBA mice. Mice were tested on the visible- or hidden-platform versions of the Morris water task starting at 17, 24, 31, or 60 days of age. Both

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f62cf22fe9f15fad5f30638e20c199b4
https://doi.org/10.1037/0735-7044.110.6.1415

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GABA(A)-receptor delta subunit knockout mice have multiple defects in behavioral responses to ethanol

Autor: R M, Mihalek, B J, Bowers, J M, Wehner, J E, Kralic, M J, VanDoren, A L, Morrow, G E, Homanics

Publikováno v: Alcoholism, clinical and experimental research. 25(12)

The gamma-aminobutyric acid type A receptors (GABARs) are involved in mediating some of the behavioral effects of beverage alcohol (ethanol). However, the unique pharmacological and behavioral responses conferred by each of the various receptor subun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cea10b6a7fe7be83dbe4574652621362
https://pubmed.ncbi.nlm.nih.gov/11781502

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Confirmation of contextual fear conditioning QTLs by short-term selection

Autor: R A, Radcliffe, M V, Lowe, J M, Wehner

Publikováno v: Behavior genetics. 30(3)

A short-term selection study for contextual fear conditioning was conducted as a confirmational strategy to analyze the chromosomal locations of five previously mapped contextual fear conditioning quantitative trait loci (QTLs). The founding populati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f21ffce802cf935f45176d7d3edd0931
https://pubmed.ncbi.nlm.nih.gov/11105392

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Mapping of quantitative trait loci for hypnotic sensitivity to ethanol in crosses derived from the C57BL/6 and DBA/2 mouse strains

Autor: R A, Radcliffe, M L, Bohl, M V, Lowe, C S, Cycowski, J M, Wehner

Publikováno v: Alcoholism, clinical and experimental research. 24(9)

Acute ethanol sensitivity is thought to be a predisposing factor toward the development of alcoholism. Accumulated evidence suggests that this characteristic may be at least partly heritable. A widely accepted approach for identifying genes thought t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::285896587036cf1af9bdb95d5122b003
https://pubmed.ncbi.nlm.nih.gov/11003198

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Mice lacking PKC gamma exhibit decreased anxiety

Autor: B J, Bowers, A C, Collins, T, Tritto, J M, Wehner

Publikováno v: Behavior genetics. 30(2)

To investigate the contribution of the PKC gamma isoform of protein kinase C (PKC) in neurochemical pathways regulating anxiety, mice lacking the gene encoding PKC gamma were tested with heterozygote and wild-type littermates in three approach-avoida

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::febd5397a033350e1675cdb03534a1a6
https://pubmed.ncbi.nlm.nih.gov/10979601

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Genetic influences on latent inhibition

Autor: T J, Gould, J M, Wehner

Publikováno v: Behavioral neuroscience. 113(6)

The present study examined the development of latent inhibition in a number of inbred strains of mice. C57BL/6J, DBA/2J, C3H/Ibg, BALB/cByJ, A/J, CBA/J, 129/SvevTac, 129/SvJ, and AKR/J mice were screened for the development of latent inhibition. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cb51d328a36c5f2817e140edb6d5cbc5
https://pubmed.ncbi.nlm.nih.gov/10636308

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Decreased ethanol sensitivity and tolerance development in gamma-protein kinase C null mutant mice is dependent on genetic background

Autor: B J, Bowers, E H, Owen, A C, Collins, A, Abeliovich, S, Tonegawa, J M, Wehner

Publikováno v: Alcoholism, clinical and experimental research. 23(3)

Initial sensitivity and tolerance development to the sedative-hypnotic and hypothermic effects of ethanol were investigated in gamma-protein kinase C (PKC) null mutant mice. Null mutants from a C57BL/6J x 129/SvJ mixed genetic background demonstrated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6d7e7e2c6f31fe183816d64eb411847f
https://pubmed.ncbi.nlm.nih.gov/10195808

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Genetic correlation between performance on an appetitive-signaled nosepoke task and voluntary ethanol consumption

Autor: S F, Logue, R J, Swartz, J M, Wehner

Publikováno v: Alcoholism, clinical and experimental research. 22(9)

The present study used a signaled appetitive nosepoke task as a measure of behavioral control or impulsivity related to reward system function in mice and determined how impulsivity correlated with voluntary ethanol consumption. Thirteen inbred strai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5483693e34fd4a0fa2e91d16f5708bdd
https://pubmed.ncbi.nlm.nih.gov/9884133

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Identification of quantitative trait loci involved in contextual and auditory-cued fear conditioning in BXD recombinant inbred strains

Autor: E H, Owen, S C, Christensen, R, Paylor, J M, Wehner

Publikováno v: Behavioral neuroscience. 111(2)

Fear conditioning shows associations formed between contextual or auditory stimuli with an unconditioned stimulus. Inbred mouse strains differ in their ability to demonstrate fear conditioning, suggesting at least a partial genetic influence. The pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5cee9a352c1bdd0b4840dd3fa0ceb3ca
https://pubmed.ncbi.nlm.nih.gov/9106670

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