Zobrazeno 1 - 10
of 19
pro vyhledávání: '"J M, Treherne"'
Autor:
D I C, Scopes, E, O'Hare, R, Jeggo, A D, Whyment, D, Spanswick, E-M, Kim, J, Gannon, H, Amijee, J M, Treherne
Publikováno v:
British journal of pharmacology. 167(2)
Amyloid-β (Aβ) aggregation into synaptotoxic, prefibrillar oligomers is a major pathogenic event underlying the neuropathology of Alzheimer's disease (AD). The pharmacological and neuroprotective properties of a novel Aβ aggregation inhibitor, SEN
Autor:
Graham Knott, S. K. A. Woodward, J. M. Treherne, Zoltán M. Varga, J. Fernandez, John G. Nicholls
Publikováno v:
Journal of Experimental Biology. 176:77-88
The ability of neurites to grow through a lesion and form synaptic connections has been analyzed in a developing mammalian spinal cord in vitro. After isolation of the entire central nervous system (CNS) of the newly born South American opossum (Mono
Autor:
Michael L.J. Ashford, J. M. Treherne
Publikováno v:
Proceedings of the Royal Society of London. Series B: Biological Sciences. 247:121-124
ATP-sensitive K$^{+}$ (ATP-K$^{+}$) channels underlie the glucose-sensing nature of pancreatic $\beta $-cells by way of their inhibition by intracellular ATP. Recently it has been proposed that ATP-K$^{+}$ channels have a similar function in certain
Autor:
J. M. Treherne, Michael L.J. Ashford
Publikováno v:
Journal of neuroendocrinology. 3(3)
A potassium-selective channel, characterized by a single channel conductance of 160 pS was demonstrated to be present in rat freshly dispersed ventromedial hypothalamic nucleus neurons. The single channel activity was shown to be dependent, using ins
Publikováno v:
British Journal of Pharmacology. 103:1745-1751
1. Measurements have been made of the inhibition by mono- and divalent cations of the binding of [3H]-(+)-N-methyl-4-methyldiphenhydramine ([3H]-QMDP) to histamine H1-receptors in homogenates of guinea-pig cerebellum. 2. The binding of [3H]-QMDP was
Publikováno v:
British Journal of Pharmacology. 101:531-540
1. The sulphonylureas, tolbutamide (0.1-10 mM) and glibenclamide (0.1-100 microM) shown not to inhibit ATP-K+ channel currents when applied to inside-out membrane patches excised from rat cultured cerebral cortex or freshly-dispersed ventromedial hyp
Publikováno v:
Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques. 54
Neuropeptides have been a subject of considerable interest in the pharmaceutical industry over the last 20 years or more. Many drug discovery teams have contributed to our understanding of neuropeptide biology but no significant drugs that act select
Publikováno v:
Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques. 51
The ability to discover new lead compounds for novel therapeutic targets is a pivotal step in drug discovery programmes. High-throughput screening (HTS) utilises a number of platforms for the rapid screening of novel targets to accelerate this proces
Autor:
I, Hajimohamadreza, J M, Treherne
Publikováno v:
Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques. 48
Publikováno v:
The Journal of physiology. 490
1. Cell-attached recordings from isolated glucose-sensitive hypothalamic neurones show that on removal of extracellular glucose there is an increased action current frequency concomitant with decreased single-channel activity. Conversely activation o