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N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder cancer in C57BL/6 X DBA/2 F1 mice as a useful model for study of chemoprevention of cancer with retinoids

Autor: P J, Becci, H J, Thompson, J M, Strum, C C, Brown, M B, Sporn, R C, Moon

Publikováno v: Cancer research. 41(3)

Highly invasive carcinomas of the urinary bladder were induced in male C57BL/6 X DBA/2 F1 (hereafter called B6D2F1) mice by gastric intubation of N-butyl-(4-hydroxybutyl)nitrosamine (OH-BBN) using a quantitative dosing schedule. Animals received eith

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bd8a1be783d1920c0f972b27e48695d9
https://pubmed.ncbi.nlm.nih.gov/7459879

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Structural alterations within N-nitrosomethylurea-induced mammary tumors after in vivo treatment with cis-hydroxyproline

Autor: J M, Strum, W M, Lewko, W R, Kidwell

Publikováno v: Laboratory investigation; a journal of technical methods and pathology. 45(4)

N-Nitrosomethylurea-induced mammary tumors in Buffalo rats were examined ultrastructurally and compared with tumors from rats treated in vivo for 9 days with cis-hydroxyproline (CHP). The tumors from untreated animals were heterogeneous histologicall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::541cf57d08b7d0074840ec7af693b0b9
https://pubmed.ncbi.nlm.nih.gov/7300247

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Angiogenic responses elicited from chorioallantoic membrane vessels by neoplastic, preneoplastic, and normal mammary tissues from GR mice

Autor: J M, Strum

Publikováno v: The American journal of pathology. 111(3)

Neoplastic tumors are able to elicit the ingrowth of new capillaries, a process known as angiogenesis. The chorioallantoic membrane (CAM) of chicken embryos was used in an assay for this response, and normal mammary glands and various mammary growths

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3cb1fcd45cbd1df96321424f4cc44bbe
https://pubmed.ncbi.nlm.nih.gov/6190405

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Vitamin A deprivation in hamsters. Correlations between tracheal epithelial morphology and serum/tissue levels of vitamin A

Autor: J M, Strum, P S, Latham, M L, Schmidt, E M, McDowell

Publikováno v: Virchows Archiv. B, Cell pathology including molecular pathology. 50(1)

The effects of vitamin A deprivation on the tracheal epithelium of young hamsters were investigated. Colchicine was administered 6 h prior to death to induce metaphase arrest, thus making it possible to quantify the mitotic rates of basal cells and s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::574bba654365f9e3fb4ac34c4b877c34
https://pubmed.ncbi.nlm.nih.gov/2867642

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Pale cell carcinoma: ultrastructure of a hormone-dependent mammary tumor in GR mice

Autor: J M, Strum

Publikováno v: The American journal of pathology. 103(2)

Pale cell carcinoma, a hormone-dependent mammary tumor in GR mice, consists mostly of islands of pale cells and dark cells, interrupted by a few areas containing keratinized cells. In this study the pale cells (electron-lucent), were arranged in band

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::38c65000e92a9e865fe98f775468ce44
https://pubmed.ncbi.nlm.nih.gov/6165245

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