Zobrazeno 1 - 5
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pro vyhledávání: '"J M, Slingerland"'
Publikováno v:
Cancer research. 58(4)
Telomerase is a ribonucleoprotein that synthesizes telomeric DNA on chromosomal ends. Telomerase activation has been seen in many immortal cell lines and cancers. Telomerase activity was analyzed in prostate carcinoma; in coexistent prostatic intraep
Autor:
J, Tsihlias, L R, Kapusta, G, DeBoer, I, Morava-Protzner, I, Zbieranowski, N, Bhattacharya, G C, Catzavelos, L H, Klotz, J M, Slingerland
Publikováno v:
Cancer research. 58(3)
p27Kip1 is a cyclin-dependent kinase inhibitor that negatively regulates cell proliferation by mediating cell cycle arrest in G1. This study was undertaken to assess the prognostic value of p27Kip1 in localized human prostate cancer. Archival materia
Publikováno v:
Oncogene. 13(11)
We have studied TGF-beta mediated G1 arrest in WM35, an early stage human melanoma cell line. These cells have lost p15INK4B expression through loss of one chromosome 9 and rearrangement of the other. In asynchronously growing WM35, TGF-beta caused r
Publikováno v:
Oncogene. 12(7)
In a search for effectors and targets of UVB signaling in mammalian cells, we screened a keratinocyte cDNA library with differentially subtracted UVB-enriched cDNA probes. One of the UVB induced cDNA clones proved to be the rat p21Cip1/WAF1 homologue
Publikováno v:
Oncogene. 11(2)
The gene encoding the cell cycle inhibitor p16INK4A (also known as p16, MTS1, CDKN2 and INK4) has been mapped to human chromosome band 9p21, a region that also contains a putative melanoma susceptibility gene. Although germline mutations in the codin