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T cell epitopes of type II collagen that regulate murine collagen-induced arthritis

Autor: L K Myers, J M Seyer, J M Stuart, K Terato, C S David, A H Kang

Publikováno v: The Journal of Immunology. 151:500-505

Chick type II collagen (CII), a protein commonly found in joint cartilage, induces an autoimmune arthritis when administered to susceptible strains of mice. A cyanogen bromide fragment of CII, CB11, contains the requisite epitopes critical for induci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39952d05c6f9e324810ff21fb4f82054
https://doi.org/10.4049/jimmunol.151.1.500

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A synthetic peptide analogue of a determinant of type II collagen prevents the onset of collagen-induced arthritis

Autor: L K Myers, E F Rosloniec, J M Seyer, J M Stuart, A H Kang

Publikováno v: The Journal of Immunology. 150:4652-4658

The immunization of genetically susceptible strains of mice with type II collagen (CII) elicits a collagen-induced arthritis that resembles rheumatoid arthritis. Our laboratory previously identified a region of CII, CII-245-270, that contains a T cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::635aa823060165160315441263ed7eaf
https://doi.org/10.4049/jimmunol.150.10.4652

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Characterization of a tolerogenic T cell epitope of type II collagen and its relevance to collagen-induced arthritis

Autor: L K Myers, K Terato, J M Seyer, J M Stuart, A H Kang

Publikováno v: The Journal of Immunology. 149:1439-1443

A synthetic peptide representing sequences of type II collagen, (CII 245-270), has previously been used to induce tolerance and suppress arthritis in DBA/1 mice. To determine important residues, a series of peptides, each containing one or two site-d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4c114a32ad7017ef7677712c16f1ec6
https://doi.org/10.4049/jimmunol.149.4.1439

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Further characterization of the loop structure of platelet glycoprotein IIIa: partial mapping of functionally significant glycoprotein IIIa epitopes

Autor: W C, Kouns, P J, Newman, K J, Puckett, A A, Miller, C D, Wall, C F, Fox, J M, Seyer, L K, Jennings

Publikováno v: Blood. 78:3215-3223

Glycoprotein (GP) IIb-IIIa serves as the platelet fibrinogen receptor. Studies of the tertiary structure of GPIIIa have shown that the protein has a large loop structure of at least 325 amino acids in length. To further characterize this loop structu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e10f6c53e6b1a74888c0f76c290bf6
https://doi.org/10.1182/blood.v78.12.3215.3215

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Immunity to type XI collagen in mice. Evidence that the alpha 3(XI) chain of type XI collagen and the alpha 1(II) chain of type II collagen share arthritogenic determinants and induce arthritis in DBA/1 mice

Autor: M A Cremer, K Terato, J M Seyer, W C Watson, G O O'Hagan, A S Townes, A H Kang

Publikováno v: The Journal of Immunology. 146:4130-4137

To determine whether native bovine type XI collagen (BXI) is arthritogenic, five strains of inbred mice were immunized with BXI/CFA. Arthritis was not observed in any of these strains, though it was prevalent in DBA/1 and B10.RIII controls immunized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dcbcb613ed30a60ea8d7a490d8dbb256
https://doi.org/10.4049/jimmunol.146.12.4130

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Induction of immune tolerance to human type I collagen in patients with systemic sclerosis by oral administration of bovine type I collagen

Autor: K M, McKown, L D, Carbone, J, Bustillo, J M, Seyer, A H, Kang, A E, Postlethwaite

Publikováno v: Arthritis and rheumatism. 43(5)

To determine whether oral tolerance to type I collagen (CI) could be induced in patients with systemic sclerosis (SSc).Twenty adult patients with limited or diffuse SSc were enrolled in a study to receive 0.1 mg of solubilized native bovine CI daily

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0ddfb7140bcfac3142ba4c894d3076e0
https://pubmed.ncbi.nlm.nih.gov/10817559

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Lack of efficacy of oral bovine type II collagen added to existing therapy in rheumatoid arthritis

Autor: K M, McKown, L D, Carbone, S B, Kaplan, J A, Aelion, K M, Lohr, M A, Cremer, J, Bustillo, M, Gonzalez, G, Kaeley, E L, Steere, G W, Somes, L K, Myers, J M, Seyer, A H, Kang, A E, Postlethwaite

Publikováno v: Arthritis and rheumatism. 42(6)

To investigate the efficacy of oral type II collagen (CII) in the treatment of rheumatoid arthritis (RA), when added to existing therapy.Patients with active RA (n = 190) were randomized into a 6-month, double-blind, placebo-controlled trial. Patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::813747bef1d13d6d085d7c96466f7d23
https://pubmed.ncbi.nlm.nih.gov/10366113

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Collagen-induced arthritis in B10.RIII mice (H-2r): identification of an arthritogenic T-cell determinant

Autor: L K, Myers, H, Miyahara, K, Terato, J M, Seyer, J M, Stuart, A H, Kang

Publikováno v: Immunology. 84(4)

Susceptibility to collagen-induced arthritis (CIA), a murine model of autoimmune arthritis, is strongly linked to only two major histocompatibility complex (MHC) haplotypes, H-2q and H-2r. In order to identify the determinants of type II collagen (CI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f65c6bd80fdb0e6aea799e835ca2555e
https://pubmed.ncbi.nlm.nih.gov/7540590

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