Zobrazeno 1 - 10
of 15
pro vyhledávání: '"J M, Salbaum"'
Autor:
J M Salbaum, Claudia Kappen
Publikováno v:
Genomics. 64:15-23
The novel mouse gene Nope was identified due to its proximity to the Punc gene on chromosome 9. With a domain structure of four immunoglobulin domains, five fibronectin type III repeats, a single transmembrane domain, and a cytoplasmic domain, Nope e
Autor:
J M Salbaum, K D Long
Publikováno v:
Molecular Biology and Evolution. 15:284-292
Immediate-early genes are part of a cellular response mechanism that reacts to biochemical, electrical, pharmacological, and physiological stimuli as well as changes in behavioral state. In the brain, immediate-early genes-such as egr-1 have been use
Autor:
Frank H. Ruddle, J. M. Salbaum, Cooduvalli S. Shashikant, Jui H. Wang, Heinz-Georg Belting, Shelia M. Violette
Publikováno v:
Proceedings of the National Academy of Sciences. 89:3805-3809
Mammalian homeobox genes are widely expressed in the developing central nervous system and are postulated to control developmental processes by regulating gene expression at the transcriptional level. In vitro studies have identified consensus DNA se
Publikováno v:
Journal of molecular neuroscience : MN. 13(1-2)
Transgenic mouse lines were generated that expressed a 2-kb amyloid precursor protein (APP) promoter/beta-galactosidase reporter gene construction. In brain, hippocampal pyramidal neurons, neurons in the deeper layers of cerebral cortex, and neurons
Publikováno v:
Goldmann, W, Hunter, N, Foster, J D, Salbaum, J M, Beyreuther, K & Hope, J 1990, ' Two alleles of a neural protein gene linked to scrapie in sheep ', Proceedings of the National Academy of Sciences, vol. 87, no. 7, pp. 2476-80 .
Sheep are the natural hosts of the pathogens that cause scrapie, an infectious degenerative disease of the central nervous system. Scrapie-associated fibrils [and their major protein, prion protein (PrP)] accumulate in the brains of all species affec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839376e1e1cee77e60b5e582cef6e000
https://europepmc.org/articles/PMC53712/
https://europepmc.org/articles/PMC53712/
Autor:
H.G. Lemaire, Gerd Multhaup, J. M. Salbaum, Konrad Beyreuther, J. Kang, Benno Müller-Hill, A. Unterbeck, R.M. Bayney
Publikováno v:
Nucleic Acids Research. 17:517-522
Alzheimer's disease (AD) is characterized by the cerebral deposition of fibrillar aggregates of the amyloid A4 protein. Complementary DNA's coding for the precursor of the amyloid A4 protein have been described. In order to identify the structure of
Autor:
H. G. Lemaire, Gerd Multhaup, Matthias Cramer, Jie Kang, Katrin Zimmermann, W. Schubert, Colin L. Masters, C. Hilbich, T. Herget, J. M. Salbaum
Publikováno v:
The EMBO Journal. 7:367-372
Cloning and sequence analysis revealed the putative amyloid A4 precursor (pre-A4) of Alzheimer's disease to have characteristics of a membrane-spanning glycoprotein. In addition to brain, pre-A4 mRNA was found in adult human muscle and other tissues.
Autor:
Peter Fischer, Ursula Mönning, L. Hutchinson, G. Multhaup, Andreas Weidemann, G. Simms, B. Rumble, R. Martins, C. Hilbich, S. Wehr, K. Beyreuther, Thomas Dyrks, Matthias Cramer, J. Beer, Stephanie J. Fuller, Colin L. Masters, J. M. Salbaum
Publikováno v:
Immunology and Alzheimer’s Disease ISBN: 9783642466366
The major protein subunit of the amyloid fibril in Alzheimer’s disease is a small molecule of 42 residues (termed A4). It is derived from a larger precursor (PreA4), the gene for which is located on chromosome 21, in close proximity to the region i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8d697b9d34ce4394ccdcf1f2ec5a271
https://doi.org/10.1007/978-3-642-46634-2_9
https://doi.org/10.1007/978-3-642-46634-2_9
Publikováno v:
Progress in clinical and biological research. 317
The A4 amyloid precursor gene of Alzheimer's Disease (PreA4 gene, App gene, PAD gene) gives rise to three different transcripts, which are generated by alternative splicing. The three transcripts are PreA4695, PreA4751 and PreA4770, according to the
Autor:
Stephanie J. Fuller, K. Beyreuther, G. Simms, C. L. Masters, G. König, J. Beer, Thomas Dyrks, Andreas Weidemann, D. Bunke, J. M. Salbaum, G. Multhaup, B. Rumble, R. Martins, C. Hilbich, Peter Fischer, Ursula Mönning
Publikováno v:
Genetics and Alzheimer’s Disease ISBN: 9783642736490
Alzheimer’s disease affects 1% of the population of the Western world and 100% of aged individuals with Down’s syndrome. It is characterized by neuronal dysfunction and depositions of. amyloid A4 protein (β-protein) in the form of intracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ee0aca6be68d99a78ae54b786c14550
https://doi.org/10.1007/978-3-642-73647-6_14
https://doi.org/10.1007/978-3-642-73647-6_14