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The Serotonin1AReceptor Partial Agonist S15535 [4-(Benzodioxan-5-yl)1-(indan-2-yl)piperazine] Enhances Cholinergic Transmission and Cognitive Function in Rodents: A Combined Neurochemical and Behavioral Analysis

Autor: Roger D. Porsolt, J M Rivet, Pierre Lestage, Anne Dekeyne, Robert Jaffard, Jean Louis Peglion, Alain P. Gobert, Elisabeth Mocaer, Benjamin Di Cara, Mirjana Carli, Sylvain Roux, Alfredo Meneses, Millan Mark

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 311:190-203

These studies examined the influence of the selective 5-hydroxytryptamine (serotonin) (5-HT)(1A) receptor partial agonist S15535 [4-(benzodioxan-5-yl)1-(indan-2-yl)piperazine] upon cholinergic transmission and cognitive function in rodents. In the ab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a911f061b1fdbda76e36681bcb8ddf83
https://doi.org/10.1124/jpet.104.069625

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P4‐001: CHANGES IN FRONTOCORTICAL INTERSTITIAL FLUID LEVELS OF BETA‐AMYLOID AND TAU PROTEIN IN TRANSGENIC MICE MODELS OF ALZHEIMER'S DISEASE

Autor: Gaelle Rollin-Jego, Esther Schenker, J M Rivet, Alain P. Gobert, Christian Czech, Sophie Dix, Fabrice Iop, Dominique Favale, Ozmen Laurence, Jill C. Richardson, Laurence Danober

Publikováno v: Alzheimer's & Dementia. 10

WEDNESDAY, JULY 16, 2014 POSTER PRESENTATIONS P4 P4-001 CHANGES IN FRONTOCORTICAL INTERSTITIAL FLUID LEVELS OF BETA-AMYLOID AND TAU PROTEIN IN TRANSGENIC MICE MODELS OF ALZHEIMER’S DISEASE Alain Gobert, Gaelle Rollin-Jego, Fabrice Iop, Jean Michel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad0a5b81cfbcc8dfd92d4aaf842b5900
https://doi.org/10.1016/j.jalz.2014.05.1515

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Mirtazapine enhances frontocortical dopaminergic and corticolimbic adrenergic, but not serotonergic, transmission by blockade of α2-adrenergic and serotonin2Creceptors: a comparison with citalopram

Autor: J. ‐M. Rivet, Adrian Newman-Tancredi, A. Adhumeau-Auclair, Françoise Lejeune, A. Dekeyne, Cussac Didier, Alain Gobert, Jean-Paul Nicolas, M.J. Millan

Publikováno v: European Journal of Neuroscience. 12:1079-1095

Mirtazapine displayed marked affinity for cloned, human alpha2A-adrenergic (AR) receptors at which it blocked noradrenaline (NA)-induced stimulation of guanosine-5'-O-(3-[35S]thio)-triphosphate ([35S]-GTPgammaS) binding. Similarly, mirtazapine showed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f30455ea8666082162f430fb5ea2e0d8
https://doi.org/10.1046/j.1460-9568.2000.00982.x

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Contrasting mechanisms of action and sensitivity to antipsychotics of phencyclidine versus amphetamine: importance of nucleus accumbens 5-HT2Asites for PCP-induced locomotion in the rat

Autor: M. Brocco, J. ‐M. Rivet, Valérie Audinot, M.J. Millan, Alain Gobert, F. Joly, Adrian Newman-Tancredi, S. Maurel, K Bervoets

Publikováno v: European Journal of Neuroscience. 11:4419-4432

In the present study, the comparative mechanisms of action of phencyclidine (PCP) and amphetamine were addressed employing the parameter of locomotion in rats. PCP-induced locomotion (PLOC) was potently blocked by the selective serotonin (5-HT)2A vs.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cda19d5108d5a1c8bcd430f60722fa7d
https://doi.org/10.1046/j.1460-9568.1999.00858.x

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Glial D-serine gates NMDA receptors at excitatory synapses in prefrontal cortex

Autor: Jean-Pierre Mothet, Millan Mark, Stéphane H. R. Oliet, J M Rivet, Ting Shi, Jonathan V. Sweedler, Jérôme Dulong, Loredano Pollegioni, Fabrice R. Turpin, Silvia Sacchi, Pascal Fossat

Publikováno v: Cerebral cortex (New York, N.Y. : 1991). 22(3)

N-methyl-D-aspartate receptors (NMDARs) subserve numerous neurophysiological and neuropathological processes in the cerebral cortex. Their activation requires the binding of glutamate and also of a coagonist. Whereas glycine and D-serine (D-ser) are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18428230e765e494cbf9ccc48d9d2650
https://pubmed.ncbi.nlm.nih.gov/21690263

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Chapter 6.1 The role of microdialysis in drug discovery: focus on antipsychotic agents

Autor: M.J. Millan, Sylvie Girardon, J M Rivet, Rodolphe Billiras, A. Gobert, B. Di Cara, Laetitia Cistarelli, Fany Panayi

Since its inception some two decades ago, microdialysis has rapidly assumed a crucial role as an interface between cellular models of drug actions in vitro and studies of their behavioural effects in vivo. Microdialysis provides invaluable informatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d50abe5b5f248ce7d6196379c689800
https://doi.org/10.1016/s1569-7339(06)16026-9

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S33005, a novel ligand at both serotonin and norepinephrine transporters: I. Receptor binding, electrophysiological, and neurochemical profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine

Autor: M J, Millan, A, Gobert, F, Lejeune, A, Newman-Tancredi, J M, Rivet, A, Auclair, J L, Peglion

Publikováno v: The Journal of pharmacology and experimental therapeutics. 298(2)

S33005 displayed marked affinity for native, rat, and cloned human serotonin (5-HT) transporters (SERT) and less pronounced affinity for norepinephrine (NE) transporters (NET), while its affinity at dopamine (DA) transporters and50 other sites was ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::75091214929e8c61231b00a7646d9c87
https://pubmed.ncbi.nlm.nih.gov/11454918

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S18616, a highly potent spiroimidazoline agonist at alpha(2)-adrenoceptors: II. Influence on monoaminergic transmission, motor function, and anxiety in comparison with dexmedetomidine and clonidine

Autor: M J, Millan, F, Lejeune, A, Gobert, M, Brocco, A, Auclair, C, Bosc, J M, Rivet, J M, Lacoste, A, Cordi, A, Dekeyne

Publikováno v: The Journal of pharmacology and experimental therapeutics. 295(3)

The alpha(2)-adrenoceptor (AR) agonist, S18616 ((S)-spiro[(1-oxa-2-amino-3-azacyclopent-2-ene)-4,2'-(8'-chloro-1' , 2',3',4'-tetrahydronaphthalene)] accompanying article), suppressed electrical activity of adrenergic neurons in the locus ceruleus, an

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https://pubmed.ncbi.nlm.nih.gov/11082458

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