Optimizing Nav1.7‐Targeted Analgesics: Revealing Off‐Target Effects of Spider Venom‐Derived Peptide Toxins and Engineering Strategies for Improvement.

Autor: Luo, Sen^1,2,3 (AUTHOR), Zhou, Xi^1,2,3 (AUTHOR) xizh@hunnu.edu.cn, Wu, Meijing^1,2,3 (AUTHOR), Wang, Gongxin⁴ (AUTHOR), Wang, Li^1,2,3 (AUTHOR), Feng, Xujun^1,2,3 (AUTHOR), Wu, Hang^1,2,3 (AUTHOR), Luo, Ren^1,2,3 (AUTHOR), Lu, Minjuan^1,2,3 (AUTHOR), Ju, Junxian^1,2,3 (AUTHOR), Wang, Wenxing^1,2,3 (AUTHOR), Yuan, Lei^1,2,3 (AUTHOR), Luo, Xiaoqing^1,2,3 (AUTHOR), Peng, Dezheng⁵ (AUTHOR), Yang, Li^1,2,3 (AUTHOR), Zhang, Qingfeng^1,2,3 (AUTHOR), Chen, Minzhi^1,2,3 (AUTHOR), Liang, Songping^1,2,3 (AUTHOR), Dong, Xiuming⁶ (AUTHOR), Hao, Guoliang^4,6 (AUTHOR)

Publikováno v: Advanced Science. 11/13/2024, Vol. 11 Issue 42, p1-16. 16p.

Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability

Autor: D J, Speca, G, Ogata, D, Mandikian, H I, Bishop, S W, Wiler, K, Eum, H Jürgen, Wenzel, E T, Doisy, L, Matt, K L, Campi, M S, Golub, J M, Nerbonne, J W, Hell, B C, Trainor, J T, Sack, P A, Schwartzkroin, J S, Trimmer

Publikováno v: Genes, brain, and behavior. 13(4)

The Kv2.1 delayed rectifier potassium channel exhibits high-level expression in both principal and inhibitory neurons throughout the central nervous system, including prominent expression in hippocampal neurons. Studies of in vitro preparations sugge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d10b5dd074baf6b538290935d57d20ef
https://pubmed.ncbi.nlm.nih.gov/24494598

Functional consequences of elimination of i(to,f) and i(to,s): early afterdepolarizations, atrioventricular block, and ventricular arrhythmias in mice lacking Kv1.4 and expressing a dominant-negative Kv4 alpha subunit

Autor: W, Guo, H, Li, B, London, J M, Nerbonne

Publikováno v: Circulation research. 87(1)

It was recently reported that the slow transient outward K(+) current, I(to, s), that is evident in mouse left ventricular septal cells is eliminated in mice with a targeted deletion of the Kv1.4 gene (Kv1.4(-/-)). The rapidly inactivating transient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d053110118a7bc875906c6a99928d5ba
https://pubmed.ncbi.nlm.nih.gov/10884364

Regulation of voltage-gated K+ channel expression in the developing mammalian myocardium

Autor: J M, Nerbonne

Publikováno v: Journal of neurobiology. 37(1)

As in neurons, depolarization-activated, Ca2+-independent outward K+ currents play prominent roles in shaping the waveforms of action potentials in myocardial cells. Several different types of voltage-gated K+ currents that contribute to the distinct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cfd419347b6abff1ff756db0d785d2cf
https://pubmed.ncbi.nlm.nih.gov/9777731

An in silico investigation of Kv2.1 potassium channel: Model building and inhibitors binding sites analysis.

Autor: Wang X; Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China., Zhang X; Information Center, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China., Zhou J; Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China., Wang W; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China., Wang X; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China., Xu B; Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China.

Publikováno v: Molecular informatics [Mol Inform] 2023 Dec; Vol. 42 (12), pp. e202300072. Date of Electronic Publication: 2023 Nov 07.