Výsledky vyhledávání - "J M, McDonnell"

Autor: M.P. De Luca, J. M. McDonnell, J.F. Grassle

Publikováno v: MTS/IEEE Oceans 2001. An Ocean Odyssey. Conference Proceedings (IEEE Cat. No.01CH37295).

In 1997, investigators at Rutgers University and the Woods Hole Oceanographic Institution installed a Long-Term Ecosystem Observatory in 15 meters of water (LEO-15) about 10 km off the New Jersey coast. This facility, operated by the Mid-Atlantic Big

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9c460191313c761739ed535db696759
https://doi.org/10.1109/oceans.2001.968225

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The structure of the IgE Cepsilon2 domain and its role in stabilizing the complex with its high-affinity receptor FcepsilonRIalpha

Autor: J M, McDonnell, R, Calvert, R L, Beavil, A J, Beavil, A J, Henry, B J, Sutton, H J, Gould, D, Cowburn

Publikováno v: Nature structural biology. 8(5)

The stability of the complex between IgE and its high-affinity receptor, FcepsilonRI, on mast cells is a critical factor in the allergic response. The long half-life of the complex of IgE bound to this receptor in situ ( approximately 2 weeks, compar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fff0bfe54024ba1c3ec3deae1a94525c
https://pubmed.ncbi.nlm.nih.gov/11323720

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Conformation of the isolated cepsilon3 domain of IgE and its complex with the high-affinity receptor, FcepsilonRI

Autor: A J, Henry, J M, McDonnell, R, Ghirlando, B J, Sutton, H J, Gould

Publikováno v: Biochemistry. 39(25)

Immunoglobulin E (IgE) exhibits a uniquely high affinity for its receptor, FcepsilonRI, on the surface of mast cells and basophils. Previous work has implicated the third domain of the constant region of the epsilon-heavy chain (Cepsilon3) in binding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9a86c7a1d89f42b608e204880561dad7
https://pubmed.ncbi.nlm.nih.gov/10858288

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Cross-reactivity of antiidiotypic antibodies with DNA in systemic lupus erythematosus

Autor: E R, Eivazova, J M, McDonnell, B J, Sutton, N A, Staines

Publikováno v: Arthritis and rheumatism. 43(2)

To assess the functional relationship between antibodies reactive with DNA and antibodies reactive with the idiotypes (idiopeptides) of anti-DNA antibodies that are associated with systemic lupus erythematosus (SLE) in mice.Antiidiotypic antibodies t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f577b2b02e7392f1991f024ef7b38565
https://pubmed.ncbi.nlm.nih.gov/10693885

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Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists

Autor: J M, McDonnell, D, Fushman, C L, Milliman, S J, Korsmeyer, D, Cowburn

Publikováno v: Cell. 96(5)

Members of the BCL2 family of proteins are key regulators of programmed cell death, acting either as apoptotic agonists or antagonists. Here we describe the solution structure of BID, presenting the structure of a proapoptotic BCL2 family member. An

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1b24415fa9a51c1f3fd156cb7a9e2ff9
https://pubmed.ncbi.nlm.nih.gov/10089878

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Identification of contact residues in the IgE binding site of human FcepsilonRIalpha

Autor: J P, Cook, A J, Henry, J M, McDonnell, R J, Owens, B J, Sutton, H J, Gould

Publikováno v: Biochemistry. 36(50)

The high-affinity receptor for immunoglobulin E (IgE), FcepsilonRI, is an alphabetagamma2 tetramer found on mast cells, basophils, and several other types of immune effector cells. The interaction of IgE with the alpha-subunit of FcepsilonRI is centr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ec05ccba82c96f6412a25a9feeeaddf9
https://pubmed.ncbi.nlm.nih.gov/9398286

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Participation of the N-terminal region of Cepsilon3 in the binding of human IgE to its high-affinity receptor FcepsilonRI

Autor: A J, Henry, J P, Cook, J M, McDonnell, G A, Mackay, J, Shi, B J, Sutton, H J, Gould

Publikováno v: Biochemistry. 36(50)

The binding of immunoglobulin E (IgE) to its high-affinity receptor (FcepsilonRI) expressed on mast cells and basophils is central to the development of an allergic reaction. Previous studies have implicated the third constant domain of IgE-Fc (Cepsi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1f4d1f89f4231fbed21667eea24e41d6
https://pubmed.ncbi.nlm.nih.gov/9398285

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Direct involvement of the CDR3-like domain of CD4 in T helper cell activation

Autor: J M, McDonnell, K J, Blank, P E, Rao, B A, Jameson

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 149(5)

The CD4 glycoprotein, a member of the Ig super-family, has long been known to play an important role in the immunologic activation of Th cells. The precise manner in which CD4 participates in this activation process is not yet understood. In an attem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::de40cc21fa0e6b59c043c8cdec9ab456
https://pubmed.ncbi.nlm.nih.gov/1387146

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Human papillomavirus DNA in tissues and ocular surface swabs of patients with conjunctival epithelial neoplasia

Autor: J M, McDonnell, P J, McDonnell, Y Y, Sun

Publikováno v: Investigative ophthalmologyvisual science. 33(1)

DNA from human papillomavirus (HPV) type 16 has been recently identified in conjunctival epithelial dysplasia and carcinoma. In other body sites, HPV 16 is thought to play a role in the development of dysplastic lesions. To further explore the relati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8d2751ee8f0e83a758acddfdb4141ffe
https://pubmed.ncbi.nlm.nih.gov/1309728

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