Zobrazeno 1 - 10
of 37
pro vyhledávání: '"J M, MacSween"'
Autor:
L. A. Fernandez, J. M. MacSween
Publikováno v:
Scandinavian Journal of Haematology. 25:382-384
In humans, therapeutic doses of lithium causes granulocytosis and lymphopenia. In vitro increased numbers of colony forming units (CFU-GM) are observed. The effect of lithium on lymphocyte colonies is unknown. We grew T cell colonies from normal indi
Publikováno v:
Clinical and Experimental Immunology. 108:557-561
SUMMARY The AMLR is decreased in chronic lymphocytic leukaemia (CLL), which is characterized by a monoclonal expansion of CD5+ B lymphocytes. Since B cells are used to stimulate the AMLR, we investigated the capacity of normal CD5+ B cells to functio
Publikováno v:
International Archives of Allergy and Immunology. 92:343-348
C57 B1/6 mice were immunized with bovine serum albumin (BSA) and Freund’s complete and incomplete adjuvants in various concentrations. Spleen cells from these animals were subsequently stimulated with concanavalin A (Con A), purified protein deriva
Publikováno v:
Annals of the New York Academy of Sciences. 628:379-381
Publikováno v:
Immunological investigations. 24(5)
Growth of human peripheral blood B cells in a B cell colony assay system is a useful technique to study the function of B cell biology. In the initial reports, T and B cells were admixed in the culture system, prior to which the T cells were treated
Autor:
J M MacSween, S L Eastwood
Publikováno v:
British Journal of Cancer
The concentrations of IgG in acidic and 3MKCl eluates of resected colonic carcinomas and adjacent normal tissue were determined by radioimmunoassay. The mean concentration of IgG was significantly higher in both acidic and KCl eluates of primary Duke
Publikováno v:
Experimental Cell Research. 107:179-190
While the in vitro adhesion and spreading behaviour of fibroblastic cells have been extensively documented, similar studies on the cells of immunological importance are still lacking. We report here the in vitro adhesion and spreading behaviour of no
Publikováno v:
Blood. 62:767-774
The mechanism of the hypogammaglobulinemia in patients with chronic lymphocytic leukemia (CLL) was studied by determining the generation of specific immunoglobulin-secreting cells in response to mitogen and antigen stimulation in culture. Normal peri
Autor:
J. M. Macsween
Publikováno v:
International Journal of Cancer. 15:246-252
Binding of globulins to -125I CEA was detected in 10 of 24 sera from patients with cancer, 13 of 26 sera from blood donors, and 7 of 27 supernates of tumor-cell suspensions. Binding was predominantly by IgM in 10 of 14 sera tested by radioimmunoelect
Publikováno v:
Blood. 67:294-298
Normal B lymphocytes are activated, proliferate, and then differentiate into plasma cells and secrete immunoglobulin (Ig). We have reported that chronic lymphocytic leukemia (CLL) T4 cells help and CLL T8 cells lack suppressor effects on Ig synthesis