Zobrazeno 1 - 7
of 7
pro vyhledávání: '"J M, Le Doux"'
Autor:
Robert Moot, Christopher B. Doering, Jennifer M. Johnston, D Whitehead, Gabriela Denning, Harold Trent Spencer, J M Le Doux, Jordan E Shields
Publikováno v:
Gene Therapy. 21:1008-1020
A difficulty in the field of gene therapy is the need to increase the susceptibility of hematopoietic stem cells (HSCs) to ex vivo genetic manipulation. To overcome this obstacle a high-throughput screen was performed to identify compounds that could
Publikováno v:
Gene Therapy. 13:873-882
Ex vivo gene therapy is a promising approach to orthopedic regenerative medicine. These strategies typically focus on the constitutive overexpression of osteogenic factors to induce osteoblastic differentiation and matrix mineralization. However, the
Publikováno v:
Biotechnology Progress. 15:1-11
Gene therapy is a new therapeutic modality with the potential of treating inherited and acquired diseases. Several viral and physicochemical vehicles have been used for the transfer of genes to mammalian cells, but recombinant retroviruses are used i
Publikováno v:
Scopus-Elsevier
Using a model recombinant retrovirus encoding the Escherichia coli lacZ gene, we have found that medium conditioned with NIH 3T3 cells and packaging cell lines derived from NIH 3T3 cells inhibits infection. Most of the inhibitory activity was greater
Publikováno v:
Biotechnology and bioengineering. 63(6)
There has been only limited success in using recombinant retroviruses to transfer genes for the purposes of human gene therapy, in part because the average number of genes delivered to the target cells (transduction efficiency) is often too low to ac
Publikováno v:
Biotechnology and bioengineering. 58(1)
We have previously shown that medium conditioned by virus producer cells inhibits retrovirus transduction, and that a portion of the inhibitory activity is sensitive to chondroitinase ABC. In this study, we have quantitatively evaluated the fraction
Publikováno v:
Biotechnology and bioengineering. 55(1)
Antisense technology is potentially a powerful means by which to selectively control gene expression. We have used antisense oligonucleotides to modulate the response of the hepatoma cell line, HepG2, to the inflammatory cytokine, IL-6, by inhibiting