Zobrazeno 1 - 10
of 25
pro vyhledávání: '"J M, Lasker"'
Autor:
S Kitareewan, T Sullivan, J M Lasker, M B Faletto, Judy L. Raucy, Joyce A. Goldstein, Burhan I. Ghanayem, M Romkes-Sparks
Publikováno v:
Biochemistry. 33:1743-1752
The present study assesses the role of members of the human CYP2C subfamily in the 4'-hydroxylation of (S)-mephenytoin. When recombinant CYP2C proteins were expressed using a yeast cDNA expression system, 2C19 stereospecifically 4'-hydroxylated (S)-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7b2f5019c63cafc1bded03a55fd3694
https://doi.org/10.1021/bi00173a017
https://doi.org/10.1021/bi00173a017
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 293(2)
The expression of glutathione (GSH)-dependent enzymes and cytochrome P450 (P450) proteins in freshly isolated proximal tubular cells from human kidney (hPT), and the effect of primary culture on these enzymes, were determined. Freshly isolated hPT ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::33639e19a27e7d49a9d9994e8ab434e6
https://pubmed.ncbi.nlm.nih.gov/10773044
https://pubmed.ncbi.nlm.nih.gov/10773044
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(3)
Tolbutamide is a sulfonylurea-type oral hypoglycemic agent whose action is terminated by hydroxylation of the tolylsulfonyl methyl moiety catalyzed by cytochrome P-450 (CYP) enzymes of the human CYP2C subfamily. Although most studies have implicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c9d758d2ac920dc4a83dd659fd07b38a
https://pubmed.ncbi.nlm.nih.gov/10681382
https://pubmed.ncbi.nlm.nih.gov/10681382
Publikováno v:
The Journal of biological chemistry. 275(6)
20-hydroxyeicosatetraenoic acid (20-HETE), an omega-hydroxylated arachidonic acid (AA) metabolite, elicits specific effects on kidney vascular and tubular function that, in turn, influence blood pressure control. The human kidney's capacity to conver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::22c6fe4b97f2d3a8834061e2fa231c62
https://pubmed.ncbi.nlm.nih.gov/10660572
https://pubmed.ncbi.nlm.nih.gov/10660572
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(10)
Omeprazole (OP) is a potent antiulcer drug that is metabolized by liver cytochrome P450 (P450) enzymes. However, the identities of the P450 isoforms responsible for its metabolism have been controversial. 5-Hydroxyomeprazole (5OH-OP) formation cosegr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c678be373c8ba7e1c9ea8868613888c7
https://pubmed.ncbi.nlm.nih.gov/8894508
https://pubmed.ncbi.nlm.nih.gov/8894508
Autor:
D E, Feierman, J M, Lasker
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(9)
The microsomal metabolism of fentanyl, a synthetic opioid commonly used in anesthesia, was investigated in human liver. Incubation of fentanyl with human hepatic microsomes fortified with NADPH resulted in the formation of a single major metabolite,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d2913ca3d225b2748230e9a39574e70
https://pubmed.ncbi.nlm.nih.gov/8886601
https://pubmed.ncbi.nlm.nih.gov/8886601
Publikováno v:
Molecular pharmacology. 49(5)
Ethanol can be oxidized to the 1-hydroxyethyl radical (HER) by rat and deer mice liver microsomal systems. Experiments were carried out to evaluate the ability of human liver microsomes to catalyze this reaction, compare the effectiveness of NADH wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f6d33474b3aa5b75fbdb80687de5b378
https://pubmed.ncbi.nlm.nih.gov/8622631
https://pubmed.ncbi.nlm.nih.gov/8622631
Publikováno v:
Molecular pharmacology. 49(2)
The mechanisms responsible for ethanol-mediated teratogenesis have not been resolved. However, possible etiologies include the local formation of the teratogen acetaldehyde or oxygen radicals by fetal ethanol-oxidizing enzymes. As alcohol dehydrogena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0448b3250da5bedabb26096fe54dba73
https://pubmed.ncbi.nlm.nih.gov/8632758
https://pubmed.ncbi.nlm.nih.gov/8632758
Publikováno v:
Hepatology (Baltimore, Md.). 22(5)
Carbohydrate-deficient transferrin (CDT) is now considered to be the most sensitive and specific biological marker of alcohol abuse. However, the mechanism by which chronic alcohol consumption causes an elevation of CDT levels in serum is still not u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eba2228c36312092bd744ce5c1b110b5
https://pubmed.ncbi.nlm.nih.gov/7590664
https://pubmed.ncbi.nlm.nih.gov/7590664
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 271(3)
In the present study, the regio- and stereoselective epoxidation of arachidonic acid by cytochromes P450 2C8 and 2C9, two members of the CYP2C gene subfamily expressed in human liver, was determined. Purified P450 isozymes, reconstituted with NADPH:P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::149b02066a8e08631212778717c0556a
https://pubmed.ncbi.nlm.nih.gov/7996455
https://pubmed.ncbi.nlm.nih.gov/7996455