Zobrazeno 1 - 10
of 16
pro vyhledávání: '"J M, Kyriakis"'
Publikováno v:
Scopus-Elsevier
The B cell-associated surface molecule CD40 plays a key role in T cell-dependent B cell maturation, as individuals with defects in either CD40 or its ligand are impaired in immunoglobulin isotype class switching and germinal center formation. CD40 si
Publikováno v:
Journal of Biological Chemistry. 269:31836-31844
In KB epidermoid cells, we previously showed that interleukin-1 alpha (IL-1) and various mitogens activate the mitogen-activated protein (MAP) kinases ERK1 and ERK2, which phosphorylate both myelin basic protein (MBP) and a peptide containing Thr669
Publikováno v:
The Journal of biological chemistry. 275(23)
Chronic stresses, including the mechanical strain caused by hypertension or excess pulmonary ventilation pressure, lead to important clinical consequences, including hypertrophy and acute respiratory distress syndrome. Pathologic hypertrophy contribu
Autor:
J M, Kyriakis
Publikováno v:
Gene expression. 7(4-6)
Inflammatory cytokines of the tumor necrosis factor (TNF) family mediate a large variety of cellular and organismal inflammatory responses and are important to the pathogenesis of a number of important disease states including arthritis, septic shock
Autor:
J M, Kyriakis
Publikováno v:
Biochemical Society symposium. 64
Signal-transduction pathways that employ members of the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) family of protein Ser/Thr kinases are widely conserved among eukaryotes. The multiplicity of these pathways al
Publikováno v:
The Journal of biological chemistry. 273(35)
Tumor necrosis factor (TNF) elicits a diverse array of inflammatory responses through engagement of its type-1 receptor (TNFR1). Many of these responses require de novo gene expression mediated by the activator protein-1 (AP-1) transcription factor.
Publikováno v:
The Journal of biological chemistry. 272(46)
Signal transduction mechanisms activated during the early stages of necrotic cell death are poorly characterized. We have recently identified the Sterile 20 (Ste20)-like oxidant stress response kinase-1, SOK-1, which is a member of the Ste20 kinase f
Autor:
D H, Teng, W L, Perry, J K, Hogan, M, Baumgard, R, Bell, S, Berry, T, Davis, D, Frank, C, Frye, T, Hattier, R, Hu, S, Jammulapati, T, Janecki, A, Leavitt, J T, Mitchell, R, Pero, D, Sexton, M, Schroeder, P H, Su, B, Swedlund, J M, Kyriakis, J, Avruch, P, Bartel, A K, Wong, S V, Tavtigian
Publikováno v:
Cancer research. 57(19)
Mitogen-activated protein kinases function in signal transduction pathways that are involved in controlling key cellular processes in many organisms. A mammalian member of this kinase family, MKK4/JNKK1/SEK1, has been reported to link upstream MEKK1
Publikováno v:
The EMBO journal. 15(1)
The B cell-associated surface molecule CD40 plays a key role in T cell-dependent B cell maturation, as individuals with defects in either CD40 or its ligand are impaired in immunoglobulin isotype class switching and germinal center formation. CD40 si
Publikováno v:
The Journal of biological chemistry. 269(50)
In KB epidermoid cells, we previously showed that interleukin-1 alpha (IL-1) and various mitogens activate the mitogen-activated protein (MAP) kinases ERK1 and ERK2, which phosphorylate both myelin basic protein (MBP) and a peptide containing Thr669