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N-(4-hydroxyphenyl)retinamide in the chemoprevention of squamous metaplasia and dysplasia of the bronchial epithelium

Autor: J M, Kurie, J S, Lee, F R, Khuri, L, Mao, R C, Morice, J J, Lee, G L, Walsh, A, Broxson, S M, Lippman, J Y, Ro, B L, Kemp, D, Liu, H A, Fritsche, X, Xu, R, Lotan, W K, Hong

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 6(8)

Lung cancer remains the number one cause of cancer-related deaths in the United States. To reduce the mortality associated with this disease, individuals at risk must be identified prior to the development of lung cancer, and effective prevention str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::83d726e8446497d8e8ea2894d08f6da8
https://pubmed.ncbi.nlm.nih.gov/10955773

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Antisense approaches enter the clinic

Autor: F R, Khuri, J M, Kurie

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 6(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a3fe47566903d716c6af8b44f4dc25af
https://pubmed.ncbi.nlm.nih.gov/10815879

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Loss of Fhit is frequent in stage I non-small cell lung cancer and in the lungs of chronic smokers

Autor: J E, Tseng, B L, Kemp, F R, Khuri, J M, Kurie, J S, Lee, X, Zhou, D, Liu, W K, Hong, L, Mao

Publikováno v: Cancer research. 59(19)

Abnormalities of FHIT, a candidate tumor suppressor gene at 3p14.2, have been found frequently in multiple tumor types including non-small cell lung cancer (NSCLC). To investigate whether FHIT inactivation plays a role in early lung tumorigenesis, Fh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::371f01e7072e3fb7375598affc0f54c9
https://pubmed.ncbi.nlm.nih.gov/10519387

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Posttranslational mechanisms contribute to the suppression of specific cyclin:CDK complexes by all-trans retinoic acid in human bronchial epithelial cells

Autor: N, Sueoka, H Y, Lee, G L, Walsh, W K, Hong, J M, Kurie

Publikováno v: Cancer research. 59(15)

Retinoids have demonstrated activity in the chemoprevention of aerodigestive tract cancer. Potentially contributing to their lung cancer chemopreventive effects, retinoids inhibit the growth of human bronchial epithelial (HBE) cells. We observed prev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::94a586c3947beb4a786f813fc22816ed
https://pubmed.ncbi.nlm.nih.gov/10447003

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Retinoids as antitumor agents: a new age of biological therapy

Autor: J M, Kurie, W K, Hong

Publikováno v: The cancer journal from Scientific American. 5(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cf3acb568bd00ba717468c3304f78762
https://pubmed.ncbi.nlm.nih.gov/10367170

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Differential responses of normal, premalignant, and malignant human bronchial epithelial cells to receptor-selective retinoids

Autor: S Y, Sun, J M, Kurie, P, Yue, M I, Dawson, B, Shroot, R A, Chandraratna, W K, Hong, R, Lotan

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 5(2)

Using an in vitro lung carcinogenesis model consisting of normal, premalignant, and malignant human bronchial epithelial (HBE) cells, we analyzed the growth inhibitory effects of 26 novel synthetic retinoic acid receptor (RAR)- and retinoid X recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a68ba9940d8c5573e0137ed1fd23fdc5
https://pubmed.ncbi.nlm.nih.gov/10037194

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Gene therapy for non-small cell lung cancer: a preliminary report of a phase I trial of adenoviral p53 gene replacement

Autor: J A, Roth, S G, Swisher, J A, Merritt, D D, Lawrence, B L, Kemp, C H, Carrasco, A K, El-Naggar, F V, Fossella, B S, Glisson, W K, Hong, F R, Khurl, J M, Kurie, J C, Nesbitt, K, Pisters, J B, Putnam, D S, Schrump, D M, Shin, G L, Walsh

Publikováno v: Seminars in oncology. 25(3 Suppl 8)

The identification of genetic lesions that lead a normal cell to become malignant presents us with the opportunity of targeting those lesions as a means of therapy. Given the key role played by the tumor suppressor gene p53 in cell cycle regulation a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f7fa4e397004ff6bf419b53eaf5210e5
https://pubmed.ncbi.nlm.nih.gov/9704675

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Higher potency of N-(4-hydroxyphenyl)retinamide than all-trans-retinoic acid in induction of apoptosis in non-small cell lung cancer cell lines

Autor: C P, Zou, J M, Kurie, D, Lotan, C C, Zou, W K, Hong, R, Lotan

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 4(5)

Most human non-small cell lung cancer (NSCLC) cell lines are refractory to all-trans-retinoic acid (ATRA). Recently, N-(4-hydroxyphenyl)retinamide (4HPR) was found to induce apoptosis in various tumor cells. In this study, we compared and contrasted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b61645ed44c6db14639d897e2c567f19
https://pubmed.ncbi.nlm.nih.gov/9607596

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