Zobrazeno 1 - 5
of 5
pro vyhledávání: '"J M, Kitzen"'
Autor:
T D, Ocain, D D, Deininger, R, Russo, N A, Senko, A, Katz, J M, Kitzen, R, Mitchell, G, Oshiro, A, Russo, R, Stupienski
Publikováno v:
Journal of medicinal chemistry. 35(5)
Modified heterocyclic phenylalanine analogues designed as replacements for the P3-P4 region were synthesized and incorporated into renin inhibitors. These inhibitors were found to have significant activity versus human recombinant renin, as well as i
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 211(3)
Two aminotetralin analogs of dopamine were studied for their effects on ganglionic transmission in the sympathetic nervous system. Nerve activity (spontaneous firing or evoked action potentials) was recorded on a preganglionic nerve (splanchnic), a m
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 206(2)
6,7-Dihydroxy-2-dimethylaminotetralin (TL-99), the 5,6-dihydroxy isomer (M-7) and dopamine were studied for cardiovascular activity in the cat and dog. TL-99 was found to be the most active of these compounds. Some of the more striking actions of TL-
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 244(3)
The hemodynamic and cardiac electrophysiologic properties of pimobendan, a new pyridazinone-benzimidazole type inotropic agent, were studied in urethane-anesthetized dogs. The cumulative i.v. administration of 0.1, 0.3, and 1.0 mg/kg pimobendan cause
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 251(2)
The antiarrhythmic and antifibrillatory effects of the beta-1 adrenoceptor antagonist celiprolol were evaluated in a chronic canine model of myocardial infarction and sudden death. Programmed electrical stimulation (PES) was performed in conscious an