Zobrazeno 1 - 6
of 6
pro vyhledávání: '"J M, Justen"'
Autor:
D C, Bullard, J M, Mobley, J M, Justen, L M, Sly, J G, Chosay, C J, Dunn, J R, Lindsey, A L, Beaudet, N D, Staite
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(5)
P-selectin plays an important role in leukocyte adherence to microvascular endothelium and is expressed in synovial tissue from patients with rheumatoid arthritis (RA). However, the contribution of P-selectin to the initiation and chronicity of joint
Autor:
J E, Chin, C A, Hatfield, G E, Winterrowd, R F, Krzesicki, K L, Shull, S F, Fidler, K P, Kolbasa, J R, Brashler, R L, Griffin, W E, Fleming, J M, Justen, L S, Banitt, G L, Bundy, I M, Richards
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 290(1)
The anti-inflammatory properties of a novel pyrrolopyrimidine, PNU-142731A, in a murine model of antigen-induced eosinophilic lung inflammation are described. PNU-142731A, when given orally, demonstrated a dose-related inhibition of eosinophil- and l
Publikováno v:
Blood. 88(8)
Leukocyte rolling and emigration in response to inflammatory stimuli appears to involve both E-selectin- and P-selectin-dependent adhesion, which suggests that these molecules have overlapping functions. To clarify their relative contributions in chr
Autor:
R J, Smith, J M, Justen, A R, McNab, C L, Rosenbloom, A N, Steele, P A, Detmers, D C, Anderson, A M, Manning
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 278(1)
We have reported that U-73122 (1-[6-[[17 beta-3-methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole- 2,5-dione) an inhibitor of phospholipase C-dependent processes in human polymorphonuclear neutrophils (PMN) and platelets, potently suppresses
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 253(2)
1-[6-[[17 beta-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]- 1H-pyrrole-2,5-dione (U-73122), an inhibitor of phospholipase C (PLC)-dependent processes in human platelets, was found to be a potent inhibitor of human polymorphonuclear neutrophil (
Publikováno v:
Biochemical pharmacology. 36(22)
Human monocyte-derived interleukin-1 (IL-1) stimulated the selective extracellular release of cytoplasmic granule-associated elastase from human neutrophils. Although extracellular calcium (Ca2+) enhances but is not required for the expression of gra