Zobrazeno 1 - 9 of 9 pro vyhledávání: '"J M, Hand"'
1
Inhibition of antigen-induced bronchoconstriction and eosinophil infiltration in the guinea pig by the cyclic AMP-specific phosphodiesterase inhibitor, rolipram
Autor: D C, Underwood, R R, Osborn, L B, Novak, J K, Matthews, S J, Newsholme, B J, Undem, J M, Hand, T J, Torphy
Publikováno v: The Journal of pharmacology and experimental therapeutics. 266(1)
Selective inhibition of the low Km cyclic AMP-specific phosphodiesterase has been shown to inhibit inflammatory cell function and relax airway smooth muscle. These studies were conducted to characterize the bronchodilator and anti-inflammatory activi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dc7caa2fa596bbcfb84878e0d9cc9a52
https://pubmed.ncbi.nlm.nih.gov/8392555
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2
Lack of late-phase airway responses in conscious guinea pigs after a variety of antigen challenges
Autor: J. M. Hand, D. C. Underwood, R. R. Osborn
Publikováno v: Agents and actions. 37(3-4)
Guinea pigs were actively sensitized by parenteral injections of ovalbumin (OA), house dust extract (HD) or Ascaris suum extract (As) in a variety of multidose regimens. At least 3 weeks after the initial sensitization injection, aerosols of the appr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e796465fec4389e68f8fdedc908fb5d7
https://pubmed.ncbi.nlm.nih.gov/1295368
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5
Prevention and reversal of aerosol LTD4-induced changes in guinea pig pulmonary mechanics by Wy-48252, an orally active LTD4/E4 receptor antagonist
Autor: J M, Hand, M A, Auen, J, Chang, I M, Englebach
Publikováno v: International archives of allergy and applied immunology. 89(1)
Anesthetized male albino guinea pigs were prepared for recording changes in the pulmonary mechanics parameters, dynamic compliance (Cdyn) and airway conductance (Gaw). Two aerosol leukotriene D4 (LTD4) challenges (0.125 microgram/ml, 3-7 breaths, 1 h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8ff8f9dac1c7dcdf2981e10988b46136
https://pubmed.ncbi.nlm.nih.gov/2731997
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6
The transit peptide of a chloroplast thylakoid membrane protein is functionally equivalent to a stromal-targeting sequence
Autor: A C Vasconcelos, J M Hand, Anthony R. Cashmore, Les J. Szabo
Publikováno v: Scopus-Elsevier
The role of transit peptides in intraorganellar targeting has been studied for a chlorophyll a/b binding (CAB) polypeptide of photosystem II (PSII) and the small subunit of ribulose-1,5-bisphosphate carboxylase (RBCS) from Pisum sativum (pea). These
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e255ad59dc9532a06aacc57ecb4cb11e
https://pubmed.ncbi.nlm.nih.gov/2684639
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8
Effect of a novel leukotriene D4 antagonist with 5-lipoxygenase and cyclooxygenase inhibitory activity, Wy-45,911, on leukotriene-D4-and antigen-induced bronchoconstriction in the guinea pig
Autor: J, Chang, J H, Musser, J M, Hand
Publikováno v: International archives of allergy and applied immunology. 86(1)
Wy-45,911 (4-[hydroxy-[3-(2-quinolinylmethoxy)phenyl] amino]-4-oxabutanoic acid, methyl ester) was found to inhibit competitively leukotriene D4 (LTD4)-induced contractions of the isolated guinea pig trachea but not those of leukotriene C4 (LTC4), ev
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a675603d138a3084b60bc207248a4956
https://pubmed.ncbi.nlm.nih.gov/2836315
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