Výsledky vyhledávání

Id1 immortalizes hematopoietic progenitors in vitro and promotes a myeloproliferative disease in vivo

Autor: Ian K. McNiece, Derek James Smith, Kimberly D. Klarmann, Peter J. M. Valk, Ming Ji, H.C. Suh, Sanne Lugthart, Ruud Delwel, K. Renn, J. M. Gooya, Jonathan R. Keller, W. Leeanansaksiri

Publikováno v: Oncogene, 27(42), 5612-5623. Nature Publishing Group

Id1 is frequently overexpressed in many cancer cells, but the functional significance of these findings is not known. To determine if Id1 could contribute to the development of hematopoietic malignancy, we reconstituted mice with hematopoietic cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9213b0a4c49477e3956c1e2bea1a46
https://hdl.handle.net/1765/14849

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D3: a gene induced during myeloid cell differentiation of Linlo c-Kit+ Sca-1(+) progenitor cells

Autor: S R, Weiler, J M, Gooya, M, Ortiz, S, Tsai, S J, Collins, J R, Keller

Publikováno v: Blood. 93(2)

In an effort to characterize molecular events contributing to lineage commitment and terminal differentiation of stem/progenitor cells, we have used differential display reverse transcription polymerase chain reaction (DDRT-PCR) and cell lines blocke

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9da5a600d3019eea3037e68603ad3f0e
https://pubmed.ncbi.nlm.nih.gov/9885214

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Engraftment of SCID mice by human bone marrow hematopoietic cells cultured in vitro: an in vivo model for human gene transfer

Autor: S E, Spence, J R, Keller, F W, Ruscetti, K T, Czarra, J M, Gooya, S, Funakoshi, D L, Longo, W J, Murphy

Publikováno v: Leukemia. 9

Demonstration of the ability of fresh human hematopoietic cells to engraft severe combined immuno-deficient (scid) mice has provided an in vivo assay for expansion and maturation of early human progenitor cells. However, engraftment of cultured hemat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::32651403f41bb5c81b4f485413c472b1
https://pubmed.ncbi.nlm.nih.gov/7475312

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Interleukin-1 (IL-1) directly and indirectly promotes hematopoietic cell growth through type I IL-1 receptor

Autor: K, Hestdal, F W, Ruscetti, R, Chizzonite, M, Ortiz, J M, Gooya, D L, Longo, J R, Keller

Publikováno v: Blood. 84(1)

Interleukin-1 (IL-1) has been shown to stimulate hematopoietic progenitor cell growth both in vitro and in vivo. Although IL-1 alone lacks the ability to promote hematopoietic progenitor growth in vitro, it is a potent synergistic factor in combinati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::de5c30bed781147ca5bba32209cfe47d
https://pubmed.ncbi.nlm.nih.gov/8018912

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Synergy between recombinant human IL-1 alpha (rHuIL-1) and M-CSF (rHuM-CSF) during the recovery of murine hematopoietic activity in myelosuppressed animals: abbreviated versus chronic administration of rHuM-CSF

Autor: C J, Kovacs, J P, Harrell, J M, Gooya, M J, Evans, R M, Johnke

Publikováno v: Experimental hematology. 20(5)

The ability of highly purified, recombinant human macrophage colony-stimulating factor (M-CSF) and recombinant human interleukin 1 alpha (IL-1) to rescue hematopoietic activity from the myelosuppressive effects of 5-fluorouracil (5-FU) was investigat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1daccd0f440644d460c1d4db8deeb952
https://pubmed.ncbi.nlm.nih.gov/1587305

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