Zobrazeno 1 - 10 of 55 pro vyhledávání: '"J M, Cowan"'
1
Akademický článek
A Conserved TCRβ Signature Dominates a Highly Polyclonal T-Cell Expansion During the Acute Phase of a Murine Malaria Infection
Autor: Natasha L. Smith, Wiebke Nahrendorf, Catherine Sutherland, Jason P. Mooney, Joanne Thompson, Philip J. Spence, Graeme J. M. Cowan
Publikováno v: Frontiers in Immunology, Vol 11 (2020)
CD4+ αβ T-cells are key mediators of the immune response to a first Plasmodium infection, undergoing extensive activation and splenic expansion during the acute phase of an infection. However, the clonality and clonal composition of this expansion
Externí odkaz: https://doaj.org/article/3491a26816554afd8b6afe87a9d05d65
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2
Akademický článek
In Human Autoimmunity, a Substantial Component of the B Cell Repertoire Consists of Polyclonal, Barely Mutated IgG+ve B Cells
Autor: Graeme J. M. Cowan, Katherine Miles, Lorenzo Capitani, Sophie S. B. Giguere, Hanna Johnsson, Carl Goodyear, Iain B. McInnes, Steffen Breusch, David Gray, Mohini Gray
Publikováno v: Frontiers in Immunology, Vol 11 (2020)
B cells are critical for promoting autoimmunity and the success of B cell depletion therapy in rheumatoid arthritis (RA) confirms their importance in driving chronic inflammation. Whilst disease specific autoantibodies are useful diagnostically, our
Externí odkaz: https://doaj.org/article/0e48b0fffc664e8ba6b84de7f262ee22
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3
Akademický článek
Antibody responses to a novel Plasmodium falciparum merozoite surface protein vaccine correlate with protection against experimental malaria infection in Aotus monkeys.
Autor: David R Cavanagh, Clemens H M Kocken, John H White, Graeme J M Cowan, Kay Samuel, Martin A Dubbeld, Annemarie Voorberg-van der Wel, Alan W Thomas, Jana S McBride, David E Arnot
Publikováno v: PLoS ONE, Vol 9, Iss 1, p e83704 (2014)
The Block 2 region of the merozoite surface protein-1 (MSP-1) of Plasmodium falciparum has been identified as a target of protective immunity by a combination of seroepidemiology and parasite population genetics. Immunogenicity studies in small anima
Externí odkaz: https://doaj.org/article/7d18435273ab44f99fe048fde02f8c32
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4
Akademický článek
A novel malaria vaccine candidate antigen expressed in Tetrahymena thermophila.
Autor: Graeme J M Cowan, Ulrike Bockau, Janna Eleni-Muus, Ingo Aldag, Kay Samuel, Alison M Creasey, Marcus W W Hartmann, David R Cavanagh
Publikováno v: PLoS ONE, Vol 9, Iss 1, p e87198 (2014)
Development of effective malaria vaccines is hampered by the problem of producing correctly folded Plasmodium proteins for use as vaccine components. We have investigated the use of a novel ciliate expression system, Tetrahymena thermophila, as a P.
Externí odkaz: https://doaj.org/article/76f6dc7e0bcc40768418ad13ebdc7062
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5
Akademický článek
A malaria vaccine based on the polymorphic block 2 region of MSP-1 that elicits a broad serotype-spanning immune response.
Autor: Graeme J M Cowan, Alison M Creasey, Kelwalin Dhanasarnsombut, Alan W Thomas, Edmond J Remarque, David R Cavanagh
Publikováno v: PLoS ONE, Vol 6, Iss 10, p e26616 (2011)
Polymorphic parasite antigens are known targets of protective immunity to malaria, but this antigenic variation poses challenges to vaccine development. A synthetic MSP-1 Block 2 construct, based on all polymorphic variants found in natural Plasmodiu
Externí odkaz: https://doaj.org/article/a98aaea91866421cb44dbb8a305cd9b1
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6
Rheumatoid arthritis patients express a skewed repertoire of polyclonal, hypomutated B-cell receptors
Autor: David Gray, Giguere Ss, Katherine Miles, Capitani L, Iain B. McInnes, Graeme J. M. Cowan, Hanna Johnsson, Goodyear C, Mel Gray, Breusch S
ObjectivesThe success of B cell depletion therapy in rheumatoid arthritis (RA) therapy testifies to their importance in disease pathogenesis, but the precise B cells mediating this are unclear. For example, it is unknown if RA patients predominantly
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c95bd5b5cb870c2ccb2e6f8092d8a20
https://doi.org/10.1101/771949
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8
Tracking B-Cell Repertoires and Clonal Histories in Normal and Malignant Lymphocytes
Autor: Surinder S. Sahota, Graeme J. M. Cowan, Nicola J. Weston-Bell
Publikováno v: Methods in Molecular Biology ISBN: 9781493970940
Methods for tracking B-cell repertoires and clonal history in normal and malignant B-cells based on immunoglobulin variable region (IGV) gene analysis have developed rapidly with the advent of massive parallel next-generation sequencing (mpNGS) proto
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e486ac7a3e2984687926413c39fa1ca
https://doi.org/10.1007/978-1-4939-7095-7_21
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9
Exposure, infection, systemic cytokine levels and antibody responses in young children concurrently exposed to schistosomiasis and malaria
Autor: David R. Cavanagh, Laura J. Appleby, Norman Nausch, Nadine Rujeni, Natsuko Imai, Takafira Mduluza, David H. Taylor, Reggis Gwisai, Francisca Mutapi, Graeme J. M. Cowan, Claire D. Bourke, Nicholas Midzi
Publikováno v: Imai, N, Rujeni, N, Nausch, N, Bourke, C D, Appleby, L J, Cowan, G, Gwisai, R, Midzi, N, Cavanagh, D, Mduluza, T, Taylor, D & Mutapi, F 2011, ' Exposure, infection, systemic cytokine levels and antibody responses in young children concurrently exposed to schistosomiasis and malaria ', Parasitology, vol. 138, no. 12, pp. 1519-1533 . https://doi.org/10.1017/S0031182011001181
Parasitology
SUMMARYDespite the overlapping distribution ofSchistosoma haematobiumandPlasmodium falciparuminfections, few studies have investigated early immune responses to both parasites in young children resident in areas co-endemic for the parasites. This stu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aea70c8116c0450d214f60c1a4e9f95f
https://doi.org/10.1017/s0031182011001181
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10
Screening trematodes for novel intervention targets: a proteomic and immunological comparison of Schistosoma haematobium, Schistosoma bovis and Echinostoma caproni
Autor: Melissa Higón, Ana Oleaga, Graeme J. M. Cowan, Francisca Mutapi, J. Russell Stothard, Rafael Toledo, Richard Burchmore, Antonio Marcilla, David R. Cavanagh, Norman Nausch, Oreto Antúnez
Publikováno v: Higon, M, Cowan, G, Nausch, N, Cavanagh, D, Oleaga, A, Toledo, R, Stothard, J R, Antunez, O, Marcilla, A, Burchmore, R & Mutapi, F 2011, ' Screening trematodes for novel intervention targets : a proteomic and immunological comparison of Schistosoma haematobium, Schistosoma bovis and Echinostoma caproni ', Parasitology, vol. 138, no. 12, pp. 1607-1619 . https://doi.org/10.1017/S0031182011000412
Parasitology
SUMMARYWith the current paucity of vaccine targets for parasitic diseases, particularly those in childhood, the aim of this study was to compare protein expression and immune cross-reactivity between the trematodes Schistosoma haematobium, S. bovis a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::696806a0b814b9be39eb5d0ece30324b
https://doi.org/10.1017/s0031182011000412
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