Výsledky vyhledávání - "J M, Chessells"

Successful haploidentical mismatched bone marrow transplantation in severe combined immunodeficiency: T cell removal using CAMPATH-I monoclonal antibody and E-rosetting

Autor: Lj Knott, R. J. Levinsky, G. Hale, David C. Linch, E. G. Davies, J. M. Chessells, Colin A. Sieff, Herman Waldmann, Gareth J. Morgan

Six patients with severe combined immunodeficiency were transplanted with bone marrow from their HLA haploidentical parents. T-lymphocytes were removed by complement mediated lysis with a monoclonal antibody (CAMPATH-I) followed by rosetting with she

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d97d492325a120d33af2fb09e99b8e4
https://doi.org/10.1111/j.1365-2141.1986.tb02953.x

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Medical Research Council leukaemia trial--UKALL V: an attempt to reduce the immunosuppressive effects of therapy in childhood acute lymphoblastic leukemia. Report to the Council by the Working Party on Leukaemia in Childhood

Autor: Susan M. Richards, J M Chessells, R M Hardy, J Durrant

The Medical Research Council UKALL V trial for children with standard-risk acute lymphoblastic leukemia (ALL) (aged 1 to 14 years, leucocyte count less than 20 X 10(9)/L) was designed to determine whether the immunosuppressive effects of treatment co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4071632958304b21794a098c0955cdf
https://ora.ox.ac.uk/objects/uuid:3d386a96-66a3-4233-925c-5f0e44a40edc

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Clonality analysis suggests that early-onset acute lymphoblastic leukaemia is of single-cell origin and implies no major role for germ cell mutations in parents

Autor: J M Chessells, F Rinaldi, T. E. Wheldon, Brenda Gibson, Robert J. Mairs, F Katz

Publikováno v: British Journal of Cancer

Childhood leukaemia presenting at a young age has been suspected of resulting from a leukaemogenic mutation in parental germ cells, either spontaneously or due to the exposure of a parent to leukaemogenic environmental hazards, particularly ionizing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f87f34769534f6c26d16c36f2b8a3207
http://europepmc.org/articles/PMC2362299

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Survival and endocrine outome after testicular relapse in acute lymphoblastic leukaemia

Autor: A D Leiper, J M Chessells, Richard Stanhope, R G Grundy

Publikováno v: Archives of Disease in Childhood. 76:190-196

Survival and endocrine status in a cohort of boys with acute lymphoblastic leukaemia (ALL) who started treatment between 1972 and 1987 and subsequently developed a testicular relapse were analysed. During this period there was a significant improveme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd48020a88a1e1d31174a2a1b19f955d
https://doi.org/10.1136/adc.76.3.190

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Late effects of intensive treatment for acute myeloid leukemia and myelodysplasia in childhood

Autor: R J Liesner, A D Leiper, J M Chessells, Ian Hann

Publikováno v: Journal of Clinical Oncology. 12:916-924

PURPOSE To perform a comprehensive assessment of the late effects of short-term intensive chemotherapy for childhood acute myeloid leukemia (AML) and myelodysplasia, and compare the sequelae of intensive chemotherapy alone with those of total-body ir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ce7bca5da885f045846b4c15ef6b66
https://doi.org/10.1200/jco.1994.12.5.916

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Neuropsychological and neurological outcome after relapse of lymphoblastic leukaemia

Autor: Faraneh Vargha-Khadem, B. G. R. Neville, A D Leiper, J M Chessells, Deborah Christie, Margaret P. Battin

Publikováno v: Archives of Disease in Childhood. 70:275-280

Fourteen children who relapsed after initial remission of leukaemia were studied. Six received a second course of cranial radiotherapy, while the remaining eight children were given total body irradiation before bone marrow transplantation. The posti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4441df73ce012eefd9d55b32916b0d9
https://doi.org/10.1136/adc.70.4.275

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A polymerase chain reaction study of the stability of Ig heavy-chain and T-cell receptor delta gene rearrangements between presentation and relapse of childhood B-lineage acute lymphoblastic leukemia

Autor: D Baines, NJ Goulden, Colin G. Steward, F Katz, A Oakhill, M N Potter, P G Martin, J M Chessells, Kenneth Langlands

Publikováno v: Blood. 83:1355-1362

Ig heavy-chain (IgH) and partial V delta 2-D delta 3 T-cell receptor (TCR) gene rearrangements were investigated, by polymerase chain reaction (PCR) amplification and sequence analysis, in 52 patients at presentation and first relapse and in 14 at bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::596fc8bbe20d019a9ef6e2bfa738233c
https://doi.org/10.1182/blood.v83.5.1355.1355

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Remission death in acute lymphoblastic leukaemia: a changing pattern

Autor: A Atra, J M Chessells, S M Richards

Publikováno v: Archives of Disease in Childhood. 69:550-554

The pattern of remission deaths was examined in 842 children with acute lymphoblastic leukaemia (ALL) treated at a single centre over 18 years. The mortality rate from leukaemia fell significantly during three consecutive time periods during which tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ba1e5c5ada5e54b854543c03e1b36ad
https://doi.org/10.1136/adc.69.5.550

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Treatment of infants with lymphoblastic leukaemia: results of the UK Infant Protocols 1987-1999

Autor: J M, Chessells, C J, Harrison, S L, Watson, A J, Vora, S M, Richards

Publikováno v: British journal of haematology. 117(2)

One hundred and twenty-six infants with acute lymphoblastic leukaemia (ALL) were treated on two consecutive protocols, Infant 87 (n = 40) and Infant 92 (n = 86), in an attempt to improve the poor prognosis of this disease. Both included intensive ind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5a07513e8c9e78c30808b8c19f7123d2
https://pubmed.ncbi.nlm.nih.gov/11972512

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