Zobrazeno 1 - 10
of 16
pro vyhledávání: '"J M, Briggs"'
Autor:
K W, Lee, J M, Briggs
Publikováno v:
Journal of computer-aided molecular design. 15(1)
A three-dimensional quantitative structure-activity relationship (3D QSAR) study has been carried out on epothilones based on comparative molecular field analyses (CoMFA) using a large data set of epothilone analogs, which are potent inhibitors of tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::697f6cb74c9b123f44b273c9a5097ba2
https://pubmed.ncbi.nlm.nih.gov/11217918
https://pubmed.ncbi.nlm.nih.gov/11217918
Publikováno v:
Journal of molecular recognition : JMR. 13(3)
The macrophage migration inhibitory factor (MIF) is a cytokine that is structurally similar to certain isomerases and for which multiple immune and catalytic roles have been proposed. Different catalytic activities have been reported for MIF, yet the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::be0406e22abe0eb5c7e99483bba22d3f
https://pubmed.ncbi.nlm.nih.gov/10867710
https://pubmed.ncbi.nlm.nih.gov/10867710
Autor:
Roberto D. Lins, W L Jorgensen, K M Masukawa, J A McCammon, J M Briggs, Frederic D. Bushman, Heather A. Carlson, Kathleen Rubins
Publikováno v:
Journal of medicinal chemistry. 43(11)
We present the first receptor-based pharmacophore model for HIV-1 integrase. The development of "dynamic" pharmacophore models is a new method that accounts for the inherent flexibility of the active site and aims to reduce the entropic penalties ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac9046ad432bec58ee5fce86f16cb98
https://pubmed.ncbi.nlm.nih.gov/10841789
https://pubmed.ncbi.nlm.nih.gov/10841789
Publikováno v:
Biopolymers. 53(4)
The HIV-1 integrase, which is essential for viral replication, catalyzes the insertion of viral DNA into the host chromosome thereby recruiting host cell machinery into making viral proteins. It represents the third main HIV enzyme target for inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bd456fe46fa63fd0de72ddeb2477dc8f
https://pubmed.ncbi.nlm.nih.gov/10685051
https://pubmed.ncbi.nlm.nih.gov/10685051
Publikováno v:
Molecular pharmacology. 56(3)
Intrastrand DNA adducts formed by cisplatin and oxaliplatin were modeled with molecular mechanics minimization and restrained molecular dynamics simulations in a comparative study. A reasonable set of force field parameters for the Pt atom were refin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::89ae54a63a5fd774920abb1a9d8b92fa
https://pubmed.ncbi.nlm.nih.gov/10462551
https://pubmed.ncbi.nlm.nih.gov/10462551
Publikováno v:
Biopolymers. 50(3)
The enzyme 4-oxalocrotonate tautomerase catalyzes the ketonization of dienols, which after further processing become intermediates in the Krebs cycle. The enzyme uses a general acid-base mechanism for proton transfer: the amino-terminal proline has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::207540e0226df28e793f4f05b2280000
https://pubmed.ncbi.nlm.nih.gov/10397792
https://pubmed.ncbi.nlm.nih.gov/10397792
Publikováno v:
Biopolymers. 46(7)
It is known that anionic surface residues play a role in the long-range electrostatic attraction between acetylcholinesterase and cationic ligands. In our current investigation, we show that anionic residues also play an important role in the behavio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6e9348db2259105f022fb12d99fdc19c
https://pubmed.ncbi.nlm.nih.gov/9838872
https://pubmed.ncbi.nlm.nih.gov/9838872
Publikováno v:
Biopolymers. 45(5)
The utility of the average Boltzmann factor around the active site of an enzyme as the predictor of the electrostatic enhancement of the substrate binding rate is tested on a set of data on wild-type acetylcholinesterase and 18 charge mutants recentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3a8e11f4b4d3bfc1b7d70fbaa86514f0
https://pubmed.ncbi.nlm.nih.gov/9530014
https://pubmed.ncbi.nlm.nih.gov/9530014
Autor:
J M, Briggs
Publikováno v:
Technology and culture. 38(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e4866afb9d1d99f3ec633132774657df
https://pubmed.ncbi.nlm.nih.gov/11619389
https://pubmed.ncbi.nlm.nih.gov/11619389
Autor:
J M, Briggs, L H, Beazlie
Publikováno v:
The Nursing clinics of North America. 31(4)
Examining the impact of endocrine disregulation is useful in managing symptoms of HIV infection in its later stages. Current studies indicate insults to the endocrine system from a variety of agents present in HIV infection. Establishing direct patho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b2bb33a7877efdb643f661a64c02a879
https://pubmed.ncbi.nlm.nih.gov/8969343
https://pubmed.ncbi.nlm.nih.gov/8969343