Zobrazeno 1 - 10
of 401
pro vyhledávání: '"J Lipiński"'
Publikováno v:
Acta Poloniae Pharmaceutica, Vol 80, Iss 3, Pp 363-372 (2023)
We were interested in finding smallest possible ligands of the NK1 receptor (NK1R). Based on structural considerations and molecular docking (scoring) we selected six simple (low molecular weight, MW) 3,5-bistrifluoromethylbenzene derivatives and tes
Externí odkaz:
https://doaj.org/article/205f630e627f425e90e4da8ebf17322e
Autor:
Piotr F. J. Lipiński, Krzysztof Łyczko
Publikováno v:
Crystals, Vol 14, Iss 4, p 342 (2024)
The crystal structure of 3,5-bistrifluoromethylhydrocinnamic acid [systematic name: 3-[3,5-bis(trifluoromethyl)phenyl]propanoic acid], C11H8F6O2, has been determined and described. The structure was subject to the Hirshfeld surface-analysis and CE-B3
Externí odkaz:
https://doaj.org/article/b1751934e0c2465b85fe8d0bb8f7ae80
Publikováno v:
Archives of Civil Engineering, Vol Vol. 66, Iss No 2, Pp 135-146 (2020)
The paper presents an approach to identify the state of fine sands on the basis of shear wave velocity measurement. Large body of experimental data was used to derive formulae which relate void ratio with shear wave velocity and mean effective stress
Externí odkaz:
https://doaj.org/article/88d97df6960443fe8f814dc149c4a17f
Publikováno v:
Archives of Civil Engineering, Vol Vol. 66, Iss No 1, Pp 69-80 (2020)
Reliable evaluation of stress-strain characteristics can be done only in the laboratory where boundary conditions with respect to stress and strain can be controlled. The most popular laboratory equipment is a triaxial apparatus. Unfortunately, stand
Externí odkaz:
https://doaj.org/article/cba7b72b2f2043aabb49be786ea94d3c
Autor:
Jolanta Dyniewicz, Stefan Mordalski, Piotr F. J. Lipiński, Andrzej J. Bojarski, Piotr Kosson, Joanna Matalińska, Aleksandra Misicka
Publikováno v:
Pharmacological Reports. 75:465-473
Background G protein-coupled receptors (GPCRs) transduce external stimuli into the cell by G proteins via an allosteric mechanism. Agonist binding to the receptor stimulates GDP/GTP exchange within the heterotrimeric G protein complex, whereas recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8d99e1280c0f243fb7220d618a72ccb
https://doi.org/10.1007/s43440-023-00457-5
https://doi.org/10.1007/s43440-023-00457-5
Autor:
Paweł K. Halik, Przemysław Koźmiński, Joanna Matalińska, Piotr F. J. Lipiński, Aleksandra Misicka, Ewa Gniazdowska
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 607 (2022)
Currently, the search for promising NK1R-positive tumor-targeting radiopharmaceuticals based on the structure of small molecular antagonists of neurokinin-1 receptor can be observed. Following this trend, we continued our evaluation of aprepitant-bas
Externí odkaz:
https://doaj.org/article/07bfb308c5454d1f949bdbfa1fc3e68e
Autor:
Piotr F. J. Lipiński, Piotr Garnuszek, Michał Maurin, Raphael Stoll, Nils Metzler-Nolte, Artur Wodyński, Jan Cz. Dobrowolski, Marta K. Dudek, Monika Orzełowska, Renata Mikołajczak
Publikováno v:
EJNMMI Research, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract Background The cholecystokinin receptor subtype 2 (CCK-2R) is an important target for diagnostic imaging and targeted radionuclide therapy (TRNT) due to its overexpression in certain cancers (e.g., medullary thyroid carcinoma (MTC)), thus ma
Externí odkaz:
https://doaj.org/article/1c6b973729cd436ea3c17cb4c7ead88c
Autor:
Karol Wtorek, Piotr F. J. Lipiński, Anna Adamska-Bartłomiejczyk, Justyna Piekielna-Ciesielska, Jarosław Sukiennik, Alicja Kluczyk, Anna Janecka
Publikováno v:
Molecules, Vol 27, Iss 1, p 151 (2021)
Our formerly described pentapeptide opioid analog Tyr-c[D-Lys-Phe-Phe-Asp]NH2 (designated RP-170), showing high affinity for the mu (MOR) and kappa (KOR) opioid receptors, was much more stable than endomorphine-2 (EM-2) in the rat brain homogenate an
Externí odkaz:
https://doaj.org/article/c146faeb9cb8454185fcfe4226b71699
Autor:
Patrycja Redkiewicz, Jolanta Dyniewicz, Ewa Witkowska, Aleksandra Misicka, Piotr F. J. Lipiński
Publikováno v:
Journal of Peptide Science.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4fa5c29411eea687d48cf6ddf478364
https://doi.org/10.1002/psc.3487
https://doi.org/10.1002/psc.3487
Autor:
Paweł K. Halik, Piotr F. J. Lipiński, Joanna Matalińska, Przemysław Koźmiński, Aleksandra Misicka, Ewa Gniazdowska
Publikováno v:
Molecules, Vol 25, Iss 16, p 3756 (2020)
Aprepitant, a lipophilic and small molecular representative of neurokinin 1 receptor antagonists, is known for its anti-proliferative activity on numerous cancer cell lines that are sensitive to Substance P mitogen action. In the presented research,
Externí odkaz:
https://doaj.org/article/2cae01f01ddf4ecd8ab3fbcae0d21fe0