Zobrazeno 1 - 10
of 509
pro vyhledávání: '"J Leibowitz"'
Autor:
Bogdan Kochetov, Phoenix D. Bell, Paulo S. Garcia, Akram S. Shalaby, Rebecca Raphael, Benjamin Raymond, Brian J. Leibowitz, Karen Schoedel, Rhonda M. Brand, Randall E. Brand, Jian Yu, Lin Zhang, Brenda Diergaarde, Robert E. Schoen, Aatur Singhi, Shikhar Uttam
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Multiplexed imaging technologies have made it possible to interrogate complex tissue microenvironments at sub-cellular resolution within their native spatial context. However, proper quantification of this complexity requires the ability to
Externí odkaz:
https://doaj.org/article/874dc85ae11740acb138f7e5d23648d4
Autor:
Hang Ruan, Brian J. Leibowitz, Yingpeng Peng, Lin Shen, Lujia Chen, Charlie Kuang, Robert E. Schoen, Xinghua Lu, Lin Zhang, Jian Yu
Publikováno v:
Molecular Biomedicine, Vol 3, Iss 1, Pp 1-16 (2022)
Abstract Mutant KRAS is a key driver in colorectal cancer (CRC) and promotes Myc translation and Myc-dependent stress adaptation and proliferation. Here, we report that the combination of two FDA-approved drugs Bortezomib and Everolimus (RAD001) (BR)
Externí odkaz:
https://doaj.org/article/897eff7e4d3547fe9e1e5347bbb62633
Autor:
Jim O. Vigoreaux, Michael J. Leibowitz
Publikováno v:
BMC Proceedings, Vol 15, Iss S2, Pp 1-11 (2021)
Abstract Progressing from postdoctoral training to a STEM faculty appointment at a Research Intensive Institution (RII) is a daunting transition, and may be especially challenging to those who have followed a less-than-conventional path or whose peer
Externí odkaz:
https://doaj.org/article/4e291f4dabef4cf8b290dc0c7a5be39d
Autor:
Alexis Espinal, Michael W. Epperly, Amitava Mukherjee, Renee Fisher, Donna Shields, Hong Wang, M. Saiful Huq, Diala Fatima Hamade, Anda M. Vlad, Lan Coffman, Ronald Buckanovich, Jian Yu, Brian J. Leibowitz, Jan-Peter van Pijkeren, Ravi B. Patel, Donna Stolz, Simon Watkins, Asim Ejaz, Joel S. Greenberger
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 10, p 5616 (2022)
(1) Background: The systemic administration of therapeutic agents to the intestine including cytokines, such as Interleukin-22 (IL-22), is compromised by damage to the microvasculature 24 hrs after total body irradiation (TBI). At that time, there is
Externí odkaz:
https://doaj.org/article/146f8975d3714d18886ab7aac7eccc6f
Autor:
Hang Ruan, Xiangyun Li, Xiang Xu, Brian J Leibowitz, Jingshan Tong, Lujia Chen, Luoquan Ao, Wei Xing, Jianhua Luo, Yanping Yu, Robert E Schoen, Nahum Sonenberg, Xinghua Lu, Lin Zhang, Jian Yu
Publikováno v:
eLife, Vol 9 (2020)
To better understand a role of eIF4E S209 in oncogenic translation, we generated EIF4ES209A/+ heterozygous knockin (4EKI) HCT 116 human colorectal cancer (CRC) cells. 4EKI had little impact on total eIF4E levels, cap binding or global translation, bu
Externí odkaz:
https://doaj.org/article/8097d9190a1f4efdac858b6f81908cd6
Autor:
Verónica A. Segarra, Sydella Blatch, Michael Boyce, Franklin Carrero-Martinez, Renato J. Aguilera, Michael J. Leibowitz, MariaElena Zavala, Latanya Hammonds-Odie, Ashanti Edwards
Publikováno v:
Journal of Microbiology & Biology Education, Vol 21, Iss 1 (2020)
Promoting diversity and inclusiveness in the STEM academic workforce remains a key challenge and national priority. Scientific societies can play a significant role in this process through the creation and implementation of programs to foster STEM ac
Externí odkaz:
https://doaj.org/article/2973f874a7fc45cc92425afdb7658906
Publikováno v:
Oncogene.
Myc is a key driver of colorectal cancer initiation and progression, but remains a difficult drug target. In this study, we show that mTOR inhibition potently suppresses intestinal polyp formation, regresses established polyps, and prolongs lifespan
Supplementary Figures S1-S8; Supplementary Materials and Methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c90ec60b9781b0f5f34ebe03b09605b
https://doi.org/10.1158/1541-7786.22519249
https://doi.org/10.1158/1541-7786.22519249
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Akademický článek
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