Zobrazeno 1 - 10
of 354
pro vyhledávání: '"J Lebowitz"'
Autor:
Joseph J. Lebowitz, Aditi Banerjee, Claire Qiao, James R. Bunzow, John T. Williams, Pascal S. Kaeser
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111915- (2023)
Summary: Modes of somatodendritic transmission range from rapid synaptic signaling to protracted regulation over distance. Somatodendritic dopamine secretion in the midbrain leads to D2 receptor-induced modulation of dopamine neurons on the timescale
Externí odkaz:
https://doaj.org/article/ebc7818d6b3c4ade8c5d72abb0722ab2
Autor:
Abeer Dagra, Douglas R. Miller, Min Lin, Adithya Gopinath, Fatemeh Shaerzadeh, Sharonda Harris, Zachary A. Sorrentino, Jonatan Fullerton Støier, Sophia Velasco, Janelle Azar, Adetola R. Alonge, Joseph J. Lebowitz, Brittany Ulm, Mengfei Bu, Carissa A. Hansen, Nikhil Urs, Benoit I. Giasson, Habibeh Khoshbouei
Publikováno v:
npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-22 (2021)
Abstract Pathophysiological damages and loss of function of dopamine neurons precede their demise and contribute to the early phases of Parkinson’s disease. The presence of aberrant intracellular pathological inclusions of the protein α-synuclein
Externí odkaz:
https://doaj.org/article/f2d73277ffa44878aef6f4a90d2e0da9
Autor:
Bobby Jones, Muthukumar Balasubramaniam, Joseph J. Lebowitz, Anne Taylor, Fernando Villalta, Habibeh Khoshbouei, Carrie Grueter, Brad Grueter, Chandravanu Dash, Jui Pandhare
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Methamphetamine (METH) is a highly addictive psychostimulant that causes long-lasting effects in the brain and increases the risk of developing neurodegenerative diseases. The cellular and molecular effects of METH in the brain are functiona
Externí odkaz:
https://doaj.org/article/c14ac558b3974efd995809baf00a9f90
Autor:
Dayana Rodriguez-Contreras, Sheng Gong, Joseph J. Lebowitz, Lev M. Fedorov, Naeem Asad, Timothy M. Dore, Tamara J. Phillips, Christopher P. Ford, John T. Williams, Kim A. Neve
Publikováno v:
Molecular Pharmacology. 103:188-198
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53ba8a989624b84222f557b312613ac0
https://doi.org/10.1124/molpharm.122.000606
https://doi.org/10.1124/molpharm.122.000606
Autor:
Joseph J. Lebowitz, Habibeh Khoshbouei
Publikováno v:
Neurobiology of Disease, Vol 134, Iss , Pp - (2020)
Despite comprising only ~ 0.001% of all neurons in the human brain, ventral midbrain dopamine neurons exert a profound influence on human behavior and cognition. As a neuromodulator, dopamine selectively inhibits or enhances synaptic signaling to coo
Externí odkaz:
https://doaj.org/article/bceb5439f48747ac83162fabd99f6595
Autor:
Danielle O. Sambo, Min Lin, Anthony Owens, Joseph J. Lebowitz, Ben Richardson, Darin A. Jagnarine, Madhur Shetty, Meghan Rodriquez, Taiwo Alonge, Mishaal Ali, Jonathan Katz, Long Yan, Marcelo Febo, L. Keith Henry, Adriaan W. Bruijnzeel, Lynette Daws, Habibeh Khoshbouei
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
The dopamine transporter (DAT), a regulator of dopamine homeostasis in the brain, and sigma-1 receptor (σ1R), an endoplasmic reticulum membrane protein, are both implicated in drug addiction. In this work, the authors investigate how σ1R modulates
Externí odkaz:
https://doaj.org/article/0d6245895b2e42a080e1391355fcd9ae
Autor:
Douglas R Miller, Joseph J Lebowitz, Dylan T Guenther, Alexander J Refowich, Carissa Hansen, Andrew P Maurer, Habibeh Khoshbouei
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0222957 (2019)
The ventral midbrain supports a variety of functions through the heterogeneity of neurons. Dopaminergic and GABA neurons within this region are particularly susceptible targets of amphetamine-class psychostimulants such as methamphetamine. While this
Externí odkaz:
https://doaj.org/article/ae51b4d89c194ed8bf4af337d838864e
Autor:
Michelle C. Gulfo, Joseph J. Lebowitz, Czarina Ramos, Dong-Woo Hwang, Kaoutsar Nasrallah, Pablo E. Castillo
Publikováno v:
bioRxiv
Hilar mossy cells (MCs) are principal excitatory neurons of the dentate gyrus (DG) that play critical roles in hippocampal function and have been implicated in brain disorders such as anxiety and epilepsy. However, the mechanisms by which MCs contrib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57357d6c8ef1727a855703f14f7e9a13
https://doi.org/10.1101/2023.05.05.539468
https://doi.org/10.1101/2023.05.05.539468
Akademický článek
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Autor:
S. Tori Ellison, Senthilkumar Duraivel, Vignesh Subramaniam, Fredrik Hugosson, Bo Yu, Joseph J. Lebowitz, Habibeh Khoshbouei, Tanmay P. Lele, Mark Q. Martindale, Thomas E. Angelini
Publikováno v:
Soft Matter. 18:8554-8560
In many tissues, cell type varies over single-cell length-scales, creating detailed heterogeneities fundamental to physiological function. To gain understanding of the relationship between tissue function and detailed structure, and eventually to eng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16a32ce82a3215f538668a878d1608f1
https://doi.org/10.1039/d2sm01013e
https://doi.org/10.1039/d2sm01013e