Zobrazeno 1 - 10
of 1 147
pro vyhledávání: '"J Lavoie"'
Autor:
Vijay Singh, Marissa A. Menard, Geidy E. Serrano, Thomas G. Beach, Hien T. Zhao, Alexis Riley-DiPaolo, Nitya Subrahmanian, Matthew J. LaVoie, Laura A. Volpicelli-Daley
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-21 (2023)
Abstract Autosomal dominant pathogenic mutations in Leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease (PD). The most common mutation, G2019S-LRRK2, increases the kinase activity of LRRK2 causing hyper-phosphorylation of its substrates.
Externí odkaz:
https://doaj.org/article/32aba7e8d1c24bdfa405421b9f329790
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
The relative polymerization of specific tau protein cores that define Alzheimer’s disease, Pick’s disease and corticobasal degeneration were investigated using amyloid fluorometry and electron microscopy. In addition, the relative prion-like acti
Externí odkaz:
https://doaj.org/article/b413ab9c9f46455582f9daf1d13b5d1d
Autor:
Daniel N. El Kodsi, Jacqueline M. Tokarew, Rajib Sengupta, Nathalie A. Lengacher, Ajanta Chatterji, Angela P. Nguyen, Heather Boston, Qiubo Jiang, Carina Palmberg, Chantal Pileggi, Chet E. Holterman, Bojan Shutinoski, Juan Li, Travis K. Fehr, Matthew J. LaVoie, Rajiv R. Ratan, Gary S. Shaw, Masashi Takanashi, Nobutaka Hattori, Christopher R. Kennedy, Mary-Ellen Harper, Arne Holmgren, Julianna J. Tomlinson, Michael G. Schlossmacher
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-21 (2023)
Abstract We recently discovered that the expression of PRKN, a young-onset Parkinson disease-linked gene, confers redox homeostasis. To further examine the protective effects of parkin in an oxidative stress model, we first combined the loss of prkn
Externí odkaz:
https://doaj.org/article/a0cf0ed0ee2143f0a980d7d5a5c6d50a
Publikováno v:
Antibiotics, Vol 13, Iss 3, p 209 (2024)
The global threat of multidrug-resistant Gram-negative bacterial pathogens necessitates the development of new and effective antibiotics. FtsZ is an essential and highly conserved cytoskeletal protein that is an appealing antibacterial target for new
Externí odkaz:
https://doaj.org/article/3695e2f711df4ee8bc9ee482638de326
Autor:
Yaron Arbel, MD, Ashish D. Patel, MD, Shaun G. Goodman, MD, MSc, Mary K. Tan, MSc, Neville Suskin, MBChB, MSc, Robert S. McKelvie, MD, PhD, Andrew L. Mathew, MD, Firas Ahmed, MD, Sohrab Lutchmedial, MDCM, Payam Dehghani, MD, Andrea J. Lavoie, MD, Thao Huynh, MD, MSc, PhD, Shahar Lavi, MD, Razi Khan, MD, Andrew T. Yan, MD, Christopher B. Fordyce, MD, MHS, MSc, Michael Heffernan, MD, PhD, Sean Jedrzkiewicz, MD, Mina Madan, MD, MHS, Shaheeda Ahmed, MD, Colin Barry, MD, Jean-Pierre Dery, MD, Akshay Bagai, MD, MHS
Publikováno v:
CJC Open, Vol 3, Iss 12, Pp 1463-1470 (2021)
Background: Extension of dual antiplatelet therapy (DAPT) beyond 1 year after acute coronary syndrome is associated with a reduction in ischemic events but also increased bleeding. The DAPT score identifies individuals likely to derive overall benefi
Externí odkaz:
https://doaj.org/article/fd68407c74874c37becfa032cd240cd6
Autor:
Jyotpal Singh, Lanishen Bhagaloo, Eric Sy, Andrea J. Lavoie, Payam Dehghani, Holly A. Bardutz, Cameron S. Mang, Josef Buttigieg, J. Patrick Neary
Publikováno v:
Physiological Reports, Vol 10, Iss 16, Pp n/a-n/a (2022)
Abstract Although acute COVID‐19 is known to cause cardiac damage in some cases, there is still much to learn about the duration and relative permanence of the damage that may occur. Long COVID is a condition that can occur when COVID‐19 symptoms
Externí odkaz:
https://doaj.org/article/8cbf6b3ae0a1412586be507c0611e72f
Autor:
Adamantios Mamais, Jillian H Kluss, Luis Bonet-Ponce, Natalie Landeck, Rebekah G Langston, Nathan Smith, Alexandra Beilina, Alice Kaganovich, Manik C Ghosh, Laura Pellegrini, Ravindran Kumaran, Ioannis Papazoglou, George R Heaton, Kirsten Harvey, Rina Bandopadhyay, Nunziata Maio, Changyoun Kim, Matthew J LaVoie, David C Gershlick, Mark R Cookson
Publikováno v:
PLoS Biology, Vol 20, Iss 5, p e3001621 (2022)
[This corrects the article DOI: 10.1371/journal.pbio.3001480.].
Externí odkaz:
https://doaj.org/article/0cfb6188812b44e8a7612e5d6a062027
Autor:
Adamantios Mamais, Jillian H Kluss, Luis Bonet-Ponce, Natalie Landeck, Rebekah G Langston, Nathan Smith, Alexandra Beilina, Alice Kaganovich, Manik C Ghosh, Laura Pellegrini, Ravindran Kumaran, Ioannis Papazoglou, George R Heaton, Rina Bandopadhyay, Nunziata Maio, Changyoun Kim, Matthew J LaVoie, David C Gershlick, Mark R Cookson
Publikováno v:
PLoS Biology, Vol 19, Iss 12, p e3001480 (2021)
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause autosomal dominant Parkinson disease (PD), while polymorphic LRRK2 variants are associated with sporadic PD. PD-linked mutations increase LRRK2 kinase activity and induce neurotoxicity in vitro
Externí odkaz:
https://doaj.org/article/71c689db45394c029f869d5ffc9ae238
Publikováno v:
Physiological Reports, Vol 9, Iss 17, Pp n/a-n/a (2021)
Abstract The spread of the novel coronavirus 2019 (COVID‐19) has caused a global pandemic. The disease has spread rapidly, and research shows that COVID‐19 can induce long‐lasting cardiac damage. COVID‐19 can result in elevated cardiac biomar
Externí odkaz:
https://doaj.org/article/732631c2dc1840c0bd6943284aa258fe
Autor:
Eric J. Bryan, Hye Yeon Sagong, Ajit K. Parhi, Mark C. Grier, Jacques Y. Roberge, Edmond J. LaVoie, Daniel S. Pilch
Publikováno v:
Antibiotics, Vol 11, Iss 5, p 693 (2022)
The emergence of multi-drug-resistant Gram-negative pathogens highlights an urgent clinical need to explore and develop new antibiotics with novel antibacterial targets. MreB is a promising antibacterial target that functions as an essential elongaso
Externí odkaz:
https://doaj.org/article/f8ac5228aca5430cb41dd1a89b48c18b