Zobrazeno 1 - 10
of 33
pro vyhledávání: '"J Lashley"'
Autor:
Ellen J. Lee, Ruth J. Napier, Emily E. Vance, Sydney J. Lashley, Agnieszka D. Truax, Jenny P. Ting, Holly L. Rosenzweig
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-12 (2022)
Abstract Background Nod-like receptors (NLRs) are critical to innate immune activation and induction of adaptive T cell responses. Yet, their role in autoinflammatory diseases of the central nervous system (CNS) remains incompletely defined. The NLR,
Externí odkaz:
https://doaj.org/article/3b4bcaf15f1940b58f3ab9e37312b029
Autor:
Amy L Seufert, James W Hickman, Ste K Traxler, Rachael M Peterson, Trent A Waugh, Sydney J Lashley, Natalia Shulzhenko, Ruth J Napier, Brooke A Napier
Publikováno v:
eLife, Vol 11 (2022)
Trained immunity is an innate immune memory response that is induced by a primary inflammatory stimulus that sensitizes monocytes and macrophages to a secondary pathogenic challenge, reprogramming the host response to infection and inflammatory disea
Externí odkaz:
https://doaj.org/article/11ab3fcbf7ef42cc9ecc00140c2d5947
Autor:
Ruth J. Napier, Ellen J. Lee, Michael P. Davey, Emily E. Vance, João M. Furtado, Paige E. Snow, Kimberly A. Samson, Sydney J. Lashley, Brieanna R. Brown, Reiko Horai, Mary J. Mattapallil, Biying Xu, Michelle C. Callegan, Luke S. Uebelhoer, Christina L. Lancioni, Richard K. Vehe, Bryce A. Binstadt, Justine R. Smith, Rachel R. Caspi, Holly L. Rosenzweig
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
How mutations in the microbial receptor NOD2 induce Blau syndrome in humans and related uveitis is unclear. Here the authors show, using Nod2-deficient mice and experimental uveitis, that Nod2 negatively regulates T cell activation and transcription
Externí odkaz:
https://doaj.org/article/5c09fe5a329b4c398f56c7642549fe79
Autor:
Amy L Seufert, James W Hickman, Ste K Traxler, Rachael M Peterson, Trent A Waugh, Sydney J Lashley, Natalia Shulzhenko, Ruth J Napier, Brooke A Napier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::443f20d57e472abd34259d52a892de61
https://doi.org/10.7554/elife.76744.sa2
https://doi.org/10.7554/elife.76744.sa2
Autor:
Ellen J. Lee, Ruth J. Napier, Emily E. Vance, Sydney J. Lashley, Agnieszka D. Truax, Jenny P. Ting, Holly L. Rosenzweig
Publikováno v:
Journal of neuroinflammation. 19(1)
Background Nod-like receptors (NLRs) are critical to innate immune activation and induction of adaptive T cell responses. Yet, their role in autoinflammatory diseases of the central nervous system (CNS) remains incompletely defined. The NLR, Nlrp12,
Autor:
Kylie Koney, Sydney J Lashley, Ellen J Lee, Emily E Vance, Dana J Philpott, Jae W Dugan, Michael M Davey, Holly L. Rosenzweig, Ruth J Napier
Publikováno v:
The Journal of Immunology. 208:58.08-58.08
We recently discovered a role for Nod2 within T cells in controlling Th17-immunity, such that deletion of Nod2 exacerbated experimental autoimmune arthritis and uveitis. Protection against opportunistic Candida albicans infection relies on intact Th1
Autor:
Amy Lorraine Seufert, James W Hickman, Ste K Traxler, Rachael M Peterson, Sydney J Lashley, Ruth J Napier, Natalia Shulzhenko, Brooke A Napier
Publikováno v:
The Journal of Immunology. 208:163.33-163.33
Dietary saturated fatty acids (SFAs) modulate circulating lipids in mice and humans, which can alter the inflammatory capacity of innate immune cells. The most common SFA in human serum, palmitic acid (PA), is enriched in Western diets, and while it
Autor:
Sydney J Lashley, Ellen J Lee, Emily E Vance, Jae W Dugan, Dana J Philpott, Michael P Davey, Holly L Rosenzweig, Ruth J Napier
Publikováno v:
The Journal of Immunology. 206:16.20-16.20
Nucleotide-binding oligomerization domain-containing protein 2 (Nod2) is a pattern recognition receptor known to promote anti-bacterial immunity yet its function in fungal disease is less understood. Here we sought to investigate the role of Nod2 in
Publikováno v:
Journal of Radioanalytical and Nuclear Chemistry. 235:235-239
Defense related activities have produced a legacy of waste that must now be addressed. Temporary storage of the waste presents a great risk to the environment from potential release of radioactive material. This has resulted in the need for a permane
Autor:
David A. Supik, Robert J Murphy, Kathleen P OˈHagan, James T. Atkinson, Christopher J. Lashley
Publikováno v:
The FASEB Journal. 26