Zobrazeno 1 - 10
of 42
pro vyhledávání: '"J L. Zweier"'
Autor:
Mark T. Ziolo, Robert L. Hamlin, J. Boslett, D. Russell, C. del Rio, J. Alecusan, Steve Roof, J. Curran, Peter J. Mohler, J. L. Zweier
Publikováno v:
Acta Physiologica. 216:421-434
Aims Insulin-like growth factor 1 (IGF-1)-dependent signalling promotes exercise-induced physiological cardiac hypertrophy. However, the in vivo therapeutic potential of IGF-1 for heart disease is not well established. Here, we test the potential the
Autor:
William L. McLaughlin, J L. Zweier, F P. Auteri, P Kuppusamy, M R. Mcclelland, Marc F. Desrosiers, G Burlinska, D M. Yaczko, C E. Dick
Publikováno v:
Radiation Physics and Chemistry. 46:1181-1184
This work describes ongoing activities in Electron Paramagnetic Resonance (EPR) dosimetry at the National Institute of Standards and Technology. Progress in the commercialization of the alanine-EPR system will be discussed along with basic research i
Publikováno v:
The Journal of biological chemistry. 276(27)
Xanthine oxidase (XO)-catalyzed nitrite reduction with nitric oxide (NO) production has been reported to occur under anaerobic conditions, but questions remain regarding the magnitude, kinetics, and biological importance of this process. To character
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 295(2)
The efficacy and mechanism of protection of a new 2,2,5, 5-tetramethylpyrroline derivative of mexiletine, MEX-NH, against ischemia/reperfusion-induced cardiac dysfunction are reported. The MEX-NH and its nitroxide metabolite are membrane-permeable an
Publikováno v:
The Journal of Experimental Medicine
We sought to understand the relationship between reactive oxygen species (ROS) and the mitochondrial permeability transition (MPT) in cardiac myocytes based on the observation of increased ROS production at sites of spontaneously deenergized mitochon
Publikováno v:
Magnetic resonance in medicine. 43(6)
Tissue oxygen content is a central parameter in physiology but is difficult to measure. We report a novel procedure for spatial mapping of oxygen by electron paramagnetic resonance (EPR) utilizing a spectral-spatial imaging data set, in which an EPR
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 292(3)
We investigated the cardioprotective efficacy of a new compound based on 2,2,5,5-tetramethyl-3-pyrroline-3-carboxamide (TPC-NH). Biochemical studies using electron paramagnetic resonance (EPR) spectroscopy suggest that TPC-NH is a scavenger of reacti
Publikováno v:
Thyroid : official journal of the American Thyroid Association. 9(3)
Graves' ophthalmopathy (GO) is attributed to an autoimmune process that results in the accumulation in retro-ocular tissue of glycosaminoglycans (GAG) that are in turn responsible for the development of clinical signs and symptoms. Retro-ocular fibro
Publikováno v:
The Journal of biological chemistry. 273(40)
It has been previously shown that besides synthesizing nitric oxide (NO), neuronal and inducible NO synthase (NOS) generates superoxide (O-2) under conditions of L-arginine depletion. However, there is controversy regarding whether endothelial NOS (e
Autor:
P, Kuppusamy, M, Afeworki, R A, Shankar, D, Coffin, M C, Krishna, S M, Hahn, J B, Mitchell, J L, Zweier
Publikováno v:
Cancer research. 58(7)
Nitroxides are redox-sensitive probes, which are useful in noninvasively delineating tissue heterogeneity especially with respect to metabolic activity and tissue oxygenation. Recent studies have shown that nitroxides are in vitro and in vivo radiopr