Zobrazeno 1 - 10
of 147
pro vyhledávání: '"J L Wong"'
Publikováno v:
Cancer Reports, Vol 7, Iss 7, Pp n/a-n/a (2024)
ABSTRACT Background N7‐methylguanosine (m7G) modification is one of the most prevalent RNA modifications in humans. Dysregulated m7G modifications caused by aberrant expression of m7G writers contribute to cancer progression and result in worse pat
Externí odkaz:
https://doaj.org/article/0efbb817a7b84f8980a93c850ed20ab1
Autor:
Natalia Pinello, Renhua Song, Quintin Lee, Emilie Calonne, Mark Larance, François Fuks, Justin J. -L. Wong
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-15 (2024)
Abstract RNA modifications have emerged as central regulators of gene expression programs. Amongst RNA modifications are N6-methyladenosine (m6A) and RNA 5-hydroxymethylcytosine (5hmC). While m6A is established as a versatile regulator of RNA metabol
Externí odkaz:
https://doaj.org/article/30faa3a3601c4e5fa04ca189700846df
Autor:
Angel Guan, Justin J.‐L. Wong
Publikováno v:
Cancer Medicine, Vol 13, Iss 7, Pp n/a-n/a (2024)
Abstract The N6‐methyladenosine (m6A) RNA modification has gained significant prominence as a new layer of regulatory mechanism that governs gene expression. Over the past decade, various m6A regulators responsible for introducing, eliminating, and
Externí odkaz:
https://doaj.org/article/0791aee5ac14415cad3d6e54fbeb9e46
Autor:
Renhua Song, Justin J-L Wong
Publikováno v:
Genes and Diseases, Vol 10, Iss 3, Pp 739-742 (2023)
Externí odkaz:
https://doaj.org/article/3a2cd29a019044f8b8bf75a6bdf15fdf
Autor:
Jaynish S. Shah, Michael J. G. Milevskiy, Veronika Petrova, Amy Y. M. Au, Justin J. L. Wong, Jane E. Visvader, Ulf Schmitz, John E. J. Rasko
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-11 (2022)
Abstract Background After many years of neglect in the field of alternative splicing, the importance of intron retention (IR) in cancer has come into focus following landmark discoveries of aberrant IR patterns in cancer. Many solid and liquid tumour
Externí odkaz:
https://doaj.org/article/683ffd8de71f4bcaa4fcd67ff3102fbf
Autor:
Jie Lan, Nicholas Rajan, Martin Bizet, Audrey Penning, Nitesh K. Singh, Diana Guallar, Emilie Calonne, Andrea Li Greci, Elise Bonvin, Rachel Deplus, Phillip J. Hsu, Sigrid Nachtergaele, Chengjie Ma, Renhua Song, Alejandro Fuentes-Iglesias, Bouchra Hassabi, Pascale Putmans, Frédérique Mies, Gerben Menschaert, Justin J. L. Wong, Jianlong Wang, Miguel Fidalgo, Bifeng Yuan, François Fuks
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
TET mediated RNA-hydroxymethylation (5hmC) has been detected in mammals, but its physiological role remains unclear. Here the authors map 5hmC during embryonic stem cell (ESC) differentiation and find that Tet-mediated RNA hydroxymethylation reduces
Externí odkaz:
https://doaj.org/article/9305faa1ca904cdba667b6f5f1a6c75f
Autor:
Quintin Lee, Matthew P Padula, Natalia Pinello, Simon H Williams, Matthew B O'Rourke, Marcilio Jorge Fumagalli, Joseph D Orkin, Renhua Song, Babak Shaban, Ori Brenner, John E Pimanda, Wolfgang Weninger, William Marciel de Souza, Amanda D Melin, Justin J-L Wong, Marcus J Crim, Sébastien Monette, Ben Roediger, Christopher J Jolly
Publikováno v:
PLoS Pathogens, Vol 16, Iss 1, p e1008262 (2020)
Mouse kidney parvovirus (MKPV) is a member of the provisional genus Chapparvovirus that causes renal disease in immune-compromised mice, with a disease course reminiscent of polyomavirus-associated nephropathy in immune-suppressed kidney transplant p
Externí odkaz:
https://doaj.org/article/c026c4cab9f2416ca6f54b057744ad7f
Autor:
Megha Rajasekhar, Ulf Schmitz, Stephane Flamant, Justin J.-L. Wong, Charles G. Bailey, William Ritchie, Jeff Holst, John E. J. Rasko
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Abstract Myelopoiesis involves differentiation of hematopoietic stem cells to cellular populations that are restricted in their self-renewal capacity, beginning with the common myeloid progenitor (CMP) and leading to mature cells including monocytes
Externí odkaz:
https://doaj.org/article/5130f8e3f39c40e099172e258a4f2129
Autor:
Shalima S. Nair, Phuc-Loi Luu, Wenjia Qu, Madhavi Maddugoda, Lily Huschtscha, Roger Reddel, Georgia Chenevix-Trench, Martina Toso, James G. Kench, Lisa G. Horvath, Vanessa M. Hayes, Phillip D. Stricker, Timothy P. Hughes, Deborah L. White, John E. J. Rasko, Justin J.-L. Wong, Susan J. Clark
Publikováno v:
Epigenetics & Chromatin, Vol 11, Iss 1, Pp 1-20 (2018)
Abstract Background Comprehensive genome-wide DNA methylation profiling is critical to gain insights into epigenetic reprogramming during development and disease processes. Among the different genome-wide DNA methylation technologies, whole genome bi
Externí odkaz:
https://doaj.org/article/4b0c244e8fac47f18cdf2eed2689bdf4
Autor:
Ulf Schmitz, Natalia Pinello, Fangzhi Jia, Sultan Alasmari, William Ritchie, Maria-Cristina Keightley, Shaniko Shini, Graham J. Lieschke, Justin J-L Wong, John E. J. Rasko
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-15 (2017)
Abstract Background While intron retention (IR) is now widely accepted as an important mechanism of mammalian gene expression control, it remains the least studied form of alternative splicing. To delineate conserved features of IR, we performed an e
Externí odkaz:
https://doaj.org/article/9b968d71e3be43b4a85b98ccc47c942e