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Autor: H Hsu, J L Viney

Publikováno v: Mucosal immunology

The TNF family cytokine TL1A (TNFSF15) costimulates T cells through its receptor DR3 (TNFRSF25) and is required for autoimmune pathology driven by diverse T cell subsets. TL1A has been linked to human inflammatory bowel disease (IBD), but its pathoge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9988b3ecde9d4be256dff176a4926f9c
https://doi.org/10.1038/mi.2011.20

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Mucosal addressin cell adhesion molecule-1: a structural and functional analysis demarcates the integrin binding motif

Autor: J L Viney, S Jones, H H Chiu, B Lagrimas, M E Renz, L G Presta, D Jackson, K J Hillan, S Lew, S Fong

Publikováno v: The Journal of Immunology. 157:2488-2497

The leukocyte integrin receptor, alpha 4 beta 7, and the mucosal addressin cell adhesion molecule-1 (MAdCAM-1) are postulated to be important in regulating lymphocyte trafficking to normal intestine. Here we provide the first description of MAdCAM-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4252c93b5e89185ec3627525637c75a5
https://doi.org/10.4049/jimmunol.157.6.2488

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Transgenic and gene knockout mice in cancer research

Autor: J. L. Viney

Publikováno v: Cancer and Metastasis Reviews. 14:77-90

Transgenic animal technology, and the use of germline manipulation for the creation of targeted gene mutations, has resulted in a plethora of murine models for cancer research. Our understanding of some of the important issues regarding the mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e32c3d41d31a42d98576d2980bc30978
https://doi.org/10.1007/bf00665792

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Modulating dendritic cells to optimize mucosal immunization protocols

Autor: E, Williamson, G M, Westrich, J L, Viney

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(7)

Oral administration of soluble protein Ag induces tolerance, a phenomenon that has hampered mucosal vaccine design. To provoke active immunity, orally administered Ag must be fed together with a mucosal adjuvant such as cholera toxin (CT). Unfortunat

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https://pubmed.ncbi.nlm.nih.gov/10490961

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Visualizing the T-cell response elicited by oral administration of soluble protein antigen

Autor: E, Williamson, J M, O'Malley, J L, Viney

Publikováno v: Immunology. 97(4)

Oral administration of soluble protein antigen induces tolerance, while particulate antigens encountered in the intestine provoke active immunity. Although the events that lead to these distinct outcomes are not yet fully characterized, they may refl

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https://pubmed.ncbi.nlm.nih.gov/10457208

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A novel model of inflammatory bowel disease: mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis

Autor: C M, Panwala, J C, Jones, J L, Viney

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 161(10)

The murine multiple drug resistance (mdr) gene, mdr1a, encodes a 170-kDa transmembrane protein that is expressed in many tissues including intestinal epithelial cells, a subset of lymphoid cells and hematopoietic cells. We report that mdr1a knockout

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https://pubmed.ncbi.nlm.nih.gov/9820555

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Beta 7 integrins and their ligands in lymphocyte migration to the gut

Autor: J L, Viney, S, Fong

Publikováno v: Chemical immunology. 71

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3235905b33e5477af55505a1b179236f
https://pubmed.ncbi.nlm.nih.gov/9761947

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Expanding dendritic cells in vivo enhances the induction of oral tolerance

Autor: J L, Viney, A M, Mowat, J M, O'Malley, E, Williamson, N A, Fanger

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 160(12)

The intestine is under perpetual challenge from both pathogens and essential nutrients, yet the mucosal immune system is able to discriminate effectively between harmful and innocuous Ags. It is likely that this selective immunoregulation is dependen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4be8e5a91132002721ff9b0862d93e55
https://pubmed.ncbi.nlm.nih.gov/9637492

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