Zobrazeno 1 - 10
of 27
pro vyhledávání: '"J L Sutko"'
Publikováno v:
Journal of microscopy. 241(1)
In photon event distribution sampling, an image formation technique for scanning microscopes, the maximum likelihood position of origin of each detected photon is acquired as a data set rather than binning photons in pixels. Subsequently, an intensit
Autor:
J L Sutko, J L Kenyon
Publikováno v:
The Journal of General Physiology
Publikováno v:
Pharmacological reviews. 49(1)
The goal of this review has been to describe the current state of the pharmacology of ryanodine and related compounds relative to the vertebrate RyRs. Resolution of questions concerning the molecular properties of RyR channel function and the contrib
Autor:
J. L. Sutko, J. A. Airey
Publikováno v:
Physiological reviews. 76(4)
Complexities in calcium signaling in eukaryotic cells require diversity in the proteins involved in generating these signals. In this review, we consider the ryanodine receptor (RyR) family of intracellular calcium release channels. This includes spe
Publikováno v:
The Journal of biological chemistry. 270(9)
Two ryanodine receptor (RyR), sarcoplasmic reticulum Ca2+ release channels, alpha and beta, co-exist in chicken skeletal muscles. To investigate a two-RyR Ca2+ release system, we compared electrically evoked Ca2+ transients in Crooked Neck Dwarf (cn/
Autor:
R A, Humerickhouse, K R, Bidasee, K, Gerzon, J T, Emmick, S, Kwon, J L, Sutko, L, Ruest, H R, Besch
Publikováno v:
The Journal of biological chemistry. 269(48)
The plant alkaloids ryanodine and dehydroryanodine are specific and potent modulators of the sarcoplasmic reticulum calcium release channel. In the present study, acidic, basic, and neutral side chains esters of these diterpene compounds were prepare
Publikováno v:
Molecular pharmacology. 44(2)
Two novel natural ryanoids from extracts of the wood of Ryania speciosa Vahl were evaluated with sarcoplasmic reticulum (SR) vesicles for their binding affinities and their activating and deactivating effects on Ca2+ release channels. The new ryanoid
Publikováno v:
BioTechniques. 10(5)
Publikováno v:
The Journal of biological chemistry. 265(24)
We report evidence for two foot protein isoforms in chicken pectoral muscle. (i) Two polypeptides with molecular masses of approximately 500 kDa copurify with [3H]ryanodine binding. (ii) Both polypeptides are associated with oligomeric proteins simil
Autor:
J L Sutko, J P Reeves
Publikováno v:
Journal of Biological Chemistry. 258:3178-3182
The initial velocity of Ca2+ uptake via the Na-Ca exchange system in cardiac sarcolemmal vesicles is competitively inhibited by extravesicular Na+. The Hill plots for multisite competitive inhibition are nonlinear, exhibiting a limiting slope of 1 at