Výsledky vyhledávání

Transcriptional repression of the α1(I) collagen gene byras is mediated in part by an intronic AP1 site

Autor: M I Parker, Paul Bornstein, J L Slack

Publikováno v: Journal of Cellular Biochemistry. 58:380-392

We have previously shown that transformation of fibroblasts by ras results in transcriptional inhibition of the alpha 1(I) gene. An alpha 1(I)-hGH chimeric plasmid containing 3.7 kb of 5' flanking and 4.4 kb of alpha 1(I) transcribed sequence was reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a268370a24a6e65c7fffe09d5ff633
https://doi.org/10.1002/jcb.240580311

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Binding of IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids

Autor: W P Arend, M Malyak, M F Smith, T D Whisenand, J L Slack, J E Sims, J G Giri, S K Dower

Publikováno v: The Journal of Immunology. 153:4766-4774

These studies have examined the binding of the three IL-1 ligands, IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist (IL-1 ra), to soluble forms of types I and II IL-1Rs (sIL-1RI and sIL-1RII). This interaction was measured in direct binding experi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6e6e7c52d04685bf062e8a49730000c
https://doi.org/10.4049/jimmunol.153.10.4766

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An upstream regulatory region mediates high-level, tissue-specific expression of the human alpha 1(I) collagen gene in transgenic mice

Autor: Paul Bornstein, J L Slack, Deann J. Liska

Publikováno v: Molecular and Cellular Biology. 11:2066-2074

Studies in vitro have not adequately resolved the role of intronic and upstream elements in regulating expression of the alpha 1(I) collagen gene. To address this issue, we generated 12 separate lines of transgenic mice with alpha 1(I) collagen-human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12822218b8c54d7772ba26f69270230e
https://doi.org/10.1128/mcb.11.4.2066

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Constitutive expression of the promyelocytic leukemia-associated oncogene PML-RARalpha in TF1 cells: isoform-specific and retinoic acid-dependent effects on growth, bcl-2 expression, and apoptosis

Autor: J L, Slack, M, Yu

Publikováno v: Blood. 91(9)

Two major isoforms of PML-RARalpha are associated with (15;17)-positive acute promyelocytic leukemia (APL); however, functional differences between these isoforms have been difficult to define, and the molecular mechanism by which each isoform contri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::90562e32762bd9b27962617d091c6ac9
https://pubmed.ncbi.nlm.nih.gov/9558392

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Association of PML-RAR alpha fusion mRNA type with pretreatment hematologic characteristics but not treatment outcome in acute promyelocytic leukemia: an intergroup molecular study

Autor: R E, Gallagher, C L, Willman, J L, Slack, J W, Andersen, Y P, Li, D, Viswanatha, C D, Bloomfield, F R, Appelbaum, C A, Schiffer, M S, Tallman, P H, Wiernik

Publikováno v: Blood. 90(4)

In each case of acute promyelocytic leukemia (APL) one of three PML-RAR alpha mRNA types is produced, depending on the break/fusion site in the PML gene that is linked to a common RAR alpha gene segment: a short (S)-form type, PML exon 3 RAR alpha ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::12f868e910792ef30cec37684559d791
https://pubmed.ncbi.nlm.nih.gov/9269786

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Transformation by v-src causes transient induction followed by repression of mouse thrombospondin-1

Autor: J L, Slack, P, Bornstein

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 5(12)

Thrombospondin-1 (TSP-1) is an extracellular glycoprotein that plays a role in neoplasia, cell growth, and differentiation. We have examined the regulation of TSP-1 mRNA in cells expressing the v-src oncogene. Rat1 fibroblasts constitutively transfor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3b6aa19db9bfa874c07d09e2c68a3632
https://pubmed.ncbi.nlm.nih.gov/7696186

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Regulation of expression of the type I collagen genes

Autor: Paul Bornstein, J L Slack, Deann J. Liska

Publikováno v: American journal of medical genetics. 45(2)

The identification and functional analysis of DNA-protein interactions in the intronic and 5' flanking regions of the type I collagen genes has begun to define a series of cis-elements and trans-acting factors which regulate transcription of these ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d61863aea2c4a7a840fecdc8b20edb1
https://pubmed.ncbi.nlm.nih.gov/8456796

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An upstream regulatory region mediates high-level, tissue-specific expression of the human alpha 1(I) collagen gene in transgenic mice

Autor: J L, Slack, D J, Liska, P, Bornstein

Publikováno v: Molecular and cellular biology. 11(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::31e0aae822131ddf91a9bf60c41bd543
https://pubmed.ncbi.nlm.nih.gov/2005897

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Regulation of cytokine and growth factor gene expression in human bone marrow stromal cells transformed with simian virus 40

Autor: J L, Slack, J, Nemunaitis, D F, Andrews, J W, Singer

Publikováno v: Blood. 75(12)

Marrow stromal cells are thought to regulate hematopoiesis by producing colony-stimulating factors (CSFs) and other cytokines, either constitutively or in response to mediators such as interleukin-1 alpha (IL-1 alpha) or tumor necrosis factor-alpha (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::779840069606aa08fbe1366d1ad29ffc
https://pubmed.ncbi.nlm.nih.gov/1693528

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