Zobrazeno 1 - 10
of 16
pro vyhledávání: '"J L Pype"'
Autor:
Stephan Gebel, Haiyan Xu, Thomas Müller, Bärbel Friedrichs, J L Pype, Svenja Diehl, Jutta Schüller, H. Weiler, Masayuki Yamamoto, Keiko Taguchi
Publikováno v:
Toxicological Sciences. 115:238-252
Cigarette smoke (CS) imposes a strong oxidative burden on exposed tissues resulting in a severely disturbed oxidant/antioxidant balance, which in the context of chronic exposure is assumed to be a key contributor to CS-related diseases. Because of it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c260bf1f87761dda247c950d96f47557
https://doi.org/10.1093/toxsci/kfq039
https://doi.org/10.1093/toxsci/kfq039
Autor:
Peter J. Barnes, Judith C.W. Mak, Wim Wuyts, Lieven Dupont, J L Pype, Maurits Demedts, Geert Verleden, Haiyan Xu, Marleen Schuermans
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 163:1010-1017
We have investigated the effect of IL-1beta on histamine H(1)-receptor (H(1)R)-mediated inositol phosphate (IP) accumulation in human airway smooth muscle cells (HASMC) and on histamine-induced contraction of human bronchial rings. Stimulation of HAS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d9eee7d4c4f77a84ff8a32444634d3
https://doi.org/10.1164/ajrccm.163.4.9911091
https://doi.org/10.1164/ajrccm.163.4.9911091
Publikováno v:
British Journal of Pharmacology. 125:1477-1484
1 We have investigated the role of protein kinase C (PKC) in the desensitization of histamine H1-receptors and in the expression of the histamine H1-receptor gene in airway smooth muscle. 2 Prolonged 4β-phorbol 12,13 dibutyrate (PDBu) pretreatment (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a6381c76faee4c3ec45b7bd984fc855
https://doi.org/10.1038/sj.bjp.0702222
https://doi.org/10.1038/sj.bjp.0702222
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 158:1479-1486
Electrical field stimulation of guinea pig tracheal strips and human bronchial rings, in vitro, evokes a cholinergic contraction mediated by the release of acetylcholine. 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) is a 5-HT1A and 5-HT7 agonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a626cf588a1b47ef2d45544ac06e18
https://doi.org/10.1164/ajrccm.158.5.9712102
https://doi.org/10.1164/ajrccm.158.5.9712102
Publikováno v:
British Journal of Pharmacology. 123:984-990
1 Pretreatment of bovine tracheal smooth muscle (BTSM) with histamine (1–100 μM, 1 h) induced a concentration-dependent desensitization of the contractile response to subsequently administered histamine, with a reduction of the maximum response of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c09a5b2597d6693b0cea7edf80eaaf45
https://doi.org/10.1038/sj.bjp.0701697
https://doi.org/10.1038/sj.bjp.0701697
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 11:23-30
The aims of this study were to investigate the effect of hyperoxia on O 2 −· , H 2 O 2 and · NO generation and iNOS mRNA levels in rat type II pneumocytes in vitro and the possible protective effect of the lazaroid U-74389G. Rat type II pneumocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf1a13679dfcc6e27b957b70a7592db
https://doi.org/10.1006/pupt.1998.0114
https://doi.org/10.1006/pupt.1998.0114
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 273:L537-L547
The effect of hyperoxia on gamma-glutamyltransferase (gamma-GT), an important enzyme for the uptake of precursor molecules for intracellular synthesis of glutathione (GSH), has not been established. Our aim was to investigate the effects of prolonged
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb1513cff001116b6dc3671069db46a
https://doi.org/10.1152/ajplung.1997.273.3.l537
https://doi.org/10.1152/ajplung.1997.273.3.l537
Publikováno v:
Journal of Applied Physiology. 77:1135-1141
5-Hydroxytryptamine (5-HT) has been demonstrated to cause both constriction and relaxation of guinea pig airways, partly through direct action on airway smooth muscle and partly through postganglionic facilitation of cholinergic neurotransmission. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f51178fb3365b0bdce39aab2410656ff
https://doi.org/10.1152/jappl.1994.77.3.1135
https://doi.org/10.1152/jappl.1994.77.3.1135
Autor:
Lieven Dupont, P DeLeyn, C J Meade, J L Pype, Maurits Demedts, Geert Verleden, Georges Deneffe
Publikováno v:
The European respiratory journal. 14(5)
Epinastine is an antihistamine drug with binding affinities at 5-hydroxytryptamine (5-HT) receptors. The current study was performed to investigate whether epinastine could modulate the cholinergic contraction in guinea pig and human airways in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e25d88ee31baf0c05d9cbf18da435dc
https://pubmed.ncbi.nlm.nih.gov/10596692
https://pubmed.ncbi.nlm.nih.gov/10596692
Autor:
Jo Van Damme, K. Fan Chung, Geert Verleden, Els Van Coillie, Patricia Menten, Ghislain Opdenakker, Lieven Dupont, J L Pype, Maurits Demedts
Publikováno v:
Scopus-Elsevier
ResearcherID
ResearcherID
We have demonstrated that, in addition to their contractile function, human airway smooth-muscle cells (HASMC) are able to express and to secrete chemokines of the monocyte chemotactic protein (MCP)/ eotaxin subfamily. This group of chemokines is bel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59718e0dc8d21d4593ef937b5ee40f1a
https://pubmed.ncbi.nlm.nih.gov/10502563
https://pubmed.ncbi.nlm.nih.gov/10502563