Zobrazeno 1 - 10
of 44
pro vyhledávání: '"J L Leonard"'
Autor:
J L Leonard
Publikováno v:
Measurement + Control, Vol 22 (1989)
Externí odkaz:
https://doaj.org/article/0bbf563a3eda4dfc9b99da5d0af36733
Autor:
J P, Sanders, S, Van der Geyten, E, Kaptein, V M, Darras, E R, Kühn, J L, Leonard, T J, Visser
Publikováno v:
Endocrinology. 140(8)
Type III iodothyronine deiodinase (D3) catalyzes the inner ring deiodination (IRD) of T4 and T3 to the inactive metabolites rT3 and 3,3'-diiodothyronine (3,3'-T2), respectively. Here we describe the cloning and characterization of complementary DNA (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b783a1577892f165a59bead56d6ff4f
https://pubmed.ncbi.nlm.nih.gov/10433225
https://pubmed.ncbi.nlm.nih.gov/10433225
Publikováno v:
The Journal of biological chemistry. 273(10)
Prokaryotic and eukaryotic cells incorporate the unusual amino acid selenocysteine at a UGA codon, which conventionally serves as a termination signal. Translation of eukaryotic selenoprotein mRNA requires a nucleotide selenocysteine insertion sequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::87f9c45a5ccb7156f381491a1b59d7db
https://pubmed.ncbi.nlm.nih.gov/9488664
https://pubmed.ncbi.nlm.nih.gov/9488664
Autor:
S, Van der Geyten, J P, Sanders, E, Kaptein, V M, Darras, E R, Kühn, J L, Leonard, T J, Visser
Publikováno v:
Endocrinology. 138(12)
In embryonic chicken liver (ECL) two types of iodothyronine deiodinases are expressed: D1 and D3. D1 catalyzes the activation as well as the inactivation of thyroid hormone by outer and inner ring deiodination, respectively. D3 only catalyzes inner r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1e5654f6f4fd8e4fe54027d4f5700dae
https://pubmed.ncbi.nlm.nih.gov/9389494
https://pubmed.ncbi.nlm.nih.gov/9389494
Publikováno v:
The Journal of biological chemistry. 271(27)
Thyroxine dynamically regulates levels of type II iodothyronine 5'-deiodinase (5'D-II) by modulating enzyme inactivation and targeting the enzyme to different pathways of internalization. 5'D-II is an approximately 200-kDa multimeric protein containi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7820c6453ce560cac30e3a2ab0c8452e
https://pubmed.ncbi.nlm.nih.gov/8663170
https://pubmed.ncbi.nlm.nih.gov/8663170
Publikováno v:
The Journal of biological chemistry. 271(27)
Type II iodothyronine 5'-deiodinase is an approximately 200-kDa multimeric enzyme in the brain that catalyzes the deiodination of thyroxine (T4) to its active metabolite, 3,5,3'-triiodothyronine. In astrocytes, cAMP stimulation is required to express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::11bf2a6f4838097e1992189c75551ab6
https://pubmed.ncbi.nlm.nih.gov/8663169
https://pubmed.ncbi.nlm.nih.gov/8663169
Publikováno v:
Journal of cellular biochemistry. 61(3)
In eukaryotes, the synthesis of selenoproteins depends on an exogenous supply of selenium, required for synthesis of the novel amino acid, selenocysteine, and on the presence of a "selenium translation element" in the 3' untranslated region of mRNA.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::53e124f6b075592d0e2c50358ac200be
https://pubmed.ncbi.nlm.nih.gov/8761945
https://pubmed.ncbi.nlm.nih.gov/8761945
Publikováno v:
RNA (New York, N.Y.). 1(5)
In eukaryotes, incorporation of selenocysteine into the polypeptide chain at a UGA codon requires a unique sequence motif, or "selenium translation element" (STE), located in the 3'-untranslated region of the mRNA. The present study examines structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3be8586b1654fc48d77770cbeaf64a48
https://pubmed.ncbi.nlm.nih.gov/7489513
https://pubmed.ncbi.nlm.nih.gov/7489513
Publikováno v:
The Journal of biological chemistry. 268(19)
3,3'5,5'-Tetraiodothyronine (T4), but not 3,3'5-triiodothyronine (T3), acutely regulates the activity of the plasma membrane-bound enzyme, type II iodothyronine 5'-deiodinase (5'D-II), by inducing internalization of the enzyme through an extranuclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::796d5afe6d759cc8f39199ebafd7d5bf
https://pubmed.ncbi.nlm.nih.gov/8390985
https://pubmed.ncbi.nlm.nih.gov/8390985
Publikováno v:
The Journal of biological chemistry. 268(7)
In the brain, thyroid hormone dynamically regulates levels of the short-lived plasma membrane protein, type II iodothyronine 5'-deiodinase. In cultured astrocytes, thyroxine modulates deiodinase levels by activating cytoskeletal-plasma membrane inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::109ef44857e05bc33cc967ae918a9f69
https://pubmed.ncbi.nlm.nih.gov/8444882
https://pubmed.ncbi.nlm.nih.gov/8444882