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pro vyhledávání: '"J L Kolman"'
Autor:
J L Kolman
Publikováno v:
PDA Journal of Pharmaceutical Science and Technology. 65:663-667
CONFERENCE PROCEEDING Proceedings of the PDA/FDA Adventitious Viruses in Biologics: Detection and Mitigation Strategies Workshop in Bethesda, MD, USA; December 1-3, 2010 Guest Editors: Arifa Khan (Bethesda, MD), Patricia Hughes (Bethesda, MD) and Mic
Autor:
J L Kolman, Frances M. D. Gulland, David Onions, Eric Delwart, Chunlin Wang, Tongling Shan, Colette Cote, Linlin Li
Publikováno v:
Journal of Virology. 85:9909-9917
California sea lions are one of the major marine mammal species along the Pacific coast of North America. Sea lions are susceptible to a wide variety of viruses, some of which can be transmitted to or from terrestrial mammals. Using an unbiased viral
Autor:
Brad Thompson, Amine Kamen, Romit Chakrabarty, Sarah Serl, Zhenbao Yu, Allison Hagerman, Matthew C. Coffey, Hue Tran, Yves Fortin, David Onions, Shi-Hsiang Shen, Robert Voyer, J L Kolman
Publikováno v:
Applied microbiology and biotechnology. 98(4)
REOLYSIN® (pelareorep) is a proprietary isolate of the reovirus T3D (Type 3 Dearing) strain which is currently being tested in clinical trials as an anticancer therapeutic agent. Reovirus genomes are composed of ten segments of double-stranded ribon
Publikováno v:
Journal of Virology. 70:1493-1504
The lytic cycle of Epstein-Barr virus (EBV) can be activated by transfection of the gene for ZEBRA, a viral basic-zipper (bZip) transcriptional activator. ZEBRA and cellular AP-1 bZip activators, such as c-Fos, have homologous DNA-binding domains, an
Publikováno v:
Proceedings of the National Academy of Sciences. 90:10115-10119
An Epstein-Barr virus-encoded protein, ZEBRA, mediates the switch from latency to the viral lytic life cycle. ZEBRA's domain structure and DNA binding specificity resemble that of cellular transcriptional activators such as c-Fos/c-Jun. We show that
Autor:
J L Kolman, David Onions
Publikováno v:
Biologicals : journal of the International Association of Biological Standardization. 38(3)
There has been an upsurge of interest in developing new veterinary and human vaccines and, in turn, this has involved the development of new mammalian and insect cell substrates. Excluding adventitious agents from these cells can be problematic, part
Publikováno v:
Proceedings of the National Academy of Sciences. 89:7772-7776
Epstein-Barr virus (EBV) genomes in the P3J-HR-1 (HR-1) Burkitt lymphoma cell line rearrange at a high rate. Previously described deletions and rearrangements in HR-1 cells have been found at sites of EBV replication in vivo, suggesting that DNA rear
Publikováno v:
The EMBO Journal. 11:1165-1176
The extrachromosomal Epstein-Barr virus (EBV) plasmid in the Burkitt lymphoma cell line, Raji, is stably associated with the nuclear matrix. This association is effected by a nuclear matrix attachment region (MAR) located in the BamHI C fragment of t
Publikováno v:
Journal of Virology. 65:4033-4041
Epstein-Barr virus (EBV) encodes a protein, ZEBRA, which enables the virus to switch from a latent to a lytic life cycle. The basic domain of ZEBRA is homologous to the Fos/Jun oncogene family, and both proteins bind the canonical AP-1 site (TGAGTCA)
Publikováno v:
Journal of virology. 71(11)
Late gene expression follows and is dependent upon lytic replication of the viral genome. Although experimental evidence is lacking, lytic viral DNA replication is believed to remove modifications or binding factors from the genome which serve to rep