Zobrazeno 1 - 10
of 337
pro vyhledávání: '"J L Jones"'
Autor:
Emer M. Brady, Thong H. Cao, Alastair J. Moss, Lavanya Athithan, Sarah L. Ayton, Emma Redman, Stavroula Argyridou, Matthew P. M. Graham-Brown, Colleen B. Maxwell, Donald J. L. Jones, Leong Ng, Thomas Yates, Melanie J Davies, Gerry P. McCann, Gaurav S. Gulsin
Publikováno v:
BMC Cardiovascular Disorders, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background Heart failure with preserved ejection fraction (HFpEF) is a heterogenous multi-system syndrome with limited efficacious treatment options. The prevalence of Type 2 diabetes (T2D) continues to rise and predisposes patients to HFpEF
Externí odkaz:
https://doaj.org/article/f14530763f914e7b9f6525e1d8bcef3b
Autor:
Diego Badillo-Sanchez, Maria Serrano Ruber, Anna M. Davies-Barrett, Jatinderpal K. Sandhu, Donald J. L. Jones, Martin Hansen, Sarah A. Inskip
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Metabolomics is a modern tool that aids in our understanding of the molecular changes in organisms. Archaeological science is a branch of archaeology that explores different archaeological materials using modern analytical tools. Human osteo
Externí odkaz:
https://doaj.org/article/280c49a3653348bfa109c369897fb877
Publikováno v:
Metabolites, Vol 13, Iss 5, p 588 (2023)
Metabolomic approaches, such as in clinical applications of living individuals, have shown potential use for solving questions regarding the past when applied to archaeological material. Here, we study for the first time the potential of this Omic ap
Externí odkaz:
https://doaj.org/article/0ea9dd8d40c849278b4da56c866b7afa
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7195 (2023)
Numerous studies have demonstrated the normal tissue-sparing effects of ultra-high dose rate ‘FLASH’ irradiation in vivo, with an associated reduction in damage burden being reported in vitro. Towards this, two key radiochemical mechanisms have b
Externí odkaz:
https://doaj.org/article/42819bda25fd48edb6d3709adee9ced4
Autor:
Bart Van Puyvelde, Katleen Van Uytfanghe, Olivier Tytgat, Laurence Van Oudenhove, Ralf Gabriels, Robbin Bouwmeester, Simon Daled, Tim Van Den Bossche, Pathmanaban Ramasamy, Sigrid Verhelst, Laura De Clerck, Laura Corveleyn, Sander Willems, Nathan Debunne, Evelien Wynendaele, Bart De Spiegeleer, Peter Judak, Kris Roels, Laurie De Wilde, Peter Van Eenoo, Tim Reyns, Marc Cherlet, Emmie Dumont, Griet Debyser, Ruben t’Kindt, Koen Sandra, Surya Gupta, Nicolas Drouin, Amy Harms, Thomas Hankemeier, Donald J. L. Jones, Pankaj Gupta, Dan Lane, Catherine S. Lane, Said El Ouadi, Jean-Baptiste Vincendet, Nick Morrice, Stuart Oehrle, Nikunj Tanna, Steve Silvester, Sally Hannam, Florian C. Sigloch, Andrea Bhangu-Uhlmann, Jan Claereboudt, N. Leigh Anderson, Morteza Razavi, Sven Degroeve, Lize Cuypers, Christophe Stove, Katrien Lagrou, Geert A. Martens, Dieter Deforce, Lennart Martens, Johannes P. C. Vissers, Maarten Dhaenens
Publikováno v:
JACS Au, Vol 1, Iss 6, Pp 750-765 (2021)
Externí odkaz:
https://doaj.org/article/da292fad17a3438b99d67c0bc99f67ad
Autor:
Saif Sattar Alaqbi, Lynsey Burke, Inna Guterman, Caleb Green, Kevin West, Raquel Palacios-Gallego, Hong Cai, Constantinos Alexandrou, Ni Ni Moe Myint, Emma Parrott, Lynne M Howells, Jennifer A Higgins, Donald J L Jones, Rajinder Singh, Robert G Britton, Cristina Tufarelli, Anne Thomas, Alessandro Rufini
Publikováno v:
PLoS ONE, Vol 17, Iss 2, p e0262364 (2022)
Research into the metabolism of the non-essential amino acid (NEAA) proline in cancer has gained traction in recent years. The last step in the proline biosynthesis pathway is catalyzed by pyrroline-5-carboxylate reductase (PYCR) enzymes. There are t
Externí odkaz:
https://doaj.org/article/a8c59ad1f4bd4b7cb6c22cc96e695c6e
Autor:
Thong Huy Cao, Donald J. L. Jones, Paulene A. Quinn, Daniel Chu Siong Chan, Narayan Hafid, Helen M. Parry, Mohapradeep Mohan, Jatinderpal K. Sandhu, Stefan D. Anker, John G. Cleland, Kenneth Dickstein, Gerasimos Filippatos, Hans L. Hillege, Marco Metra, Piotr Ponikowski, Nilesh J. Samani, Dirk J. Van Veldhuisen, Faiez Zannad, Aeilko H. Zwinderman, Adriaan A. Voors, Chim C. Lang, Leong L. Ng
Publikováno v:
Clinical Proteomics, Vol 15, Iss 1, Pp 1-9 (2018)
Abstract Background Current risk prediction models in heart failure (HF) including clinical characteristics and biomarkers only have moderate predictive value. The aim of this study was to use matrix assisted laser desorption ionisation mass spectrom
Externí odkaz:
https://doaj.org/article/7d848e9aa7b4408487993da9ac338a8b
Autor:
Jenny Hällqvist, Dan Lane, Andrew Shapanis, Kayleigh Davis, Wendy E. Heywood, Ivan Doykov, Justyna Śpiewak, Nana Ghansah, Brian Keevil, Pankaj Gupta, Rebekah Jukes-Jones, Raj Singh, Dominic Foley, Johannes P.C. Vissers, Rebecca Pattison, Samantha Ferries, Robert Wardle, Amy Bartlett, Lisa J. Calton, Leigh Anderson, Morteza Razavi, Terry Pearson, Matt Pope, Richard Yip, Leong L. Ng, Benjamin I. Nicholas, Alistair Bailey, Dan Noel, R. Neil Dalton, Simon Heales, Christopher Hopley, Andrew R. Pitt, Perdita Barran, Donald J. L. Jones, Kevin Mills, Paul Skipp, Rachel S. Carling
Publikováno v:
Clinical Chemistry and Laboratory Medicine (CCLM). 61:302-310
Objectives During 2020, the UK’s Department of Health and Social Care (DHSC) established the Moonshot programme to fund various diagnostic approaches for the detection of SARS-CoV-2, the pathogen behind the COVID-19 pandemic. Mass spectrometry was
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-8 (2018)
Abstract Background A wealth of evidence implicates both central and peripheral immune changes as contributing to the pathogenesis of Parkinson’s disease (PD). It is critical to better understand this aspect of PD given that it is a tractable targe
Externí odkaz:
https://doaj.org/article/84edb71634ec4f8ab1b6847da3ab50ce
Autor:
Elena Piletska, Dana Thompson, Rebecca Jones, Alvaro Garcia Cruz, Marta Poblocka, Francesco Canfarotta, Rachel Norman, Salvador Macip, Donald J. L. Jones, Sergey Piletsky
Publikováno v:
Nanoscale Advances. 4:5304-5311
Cellular senescence has proved to be a strong contributor to ageing and age-related diseases, such as cancer and atherosclerosis. Therefore, the protein content of senescent cells is highly relevant to drug discovery, diagnostics and therapeutic appl