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Embryonic stem cell lines from MRL mice allow genetic modification in a murine model of autoimmune disease

Publikováno v: The Journal of Immunology. 159:4376-4381

The MRL/MpJ-Fas(lpr) (MRL-lpr/lpr) mouse spontaneously develops a generalized autoimmune disease with features similar to those of systemic lupus erythematosus. This mouse strain provides a valuable system for identifying and characterizing the multi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::061fbf0b22be16aa6f61048c860c97fb
https://doi.org/10.4049/jimmunol.159.9.4376

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Mechanisms of platelet-activating factor-induced lipid body formation: requisite roles for 5-lipoxygenase and de novo protein synthesis in the compartmentalization of neutrophil lipids

Autor: Patrícia T. Bozza, J L Payne, J L Goulet, Peter F. Weller

Publikováno v: The Journal of Experimental Medicine

Lipid bodies, lipid rich cytoplasmic inclusions, are characteristically abundant in vivo in leukocytes associated with inflammation. Because lipid bodies are potential reservoirs of esterified arachidonate and sites at which eicosanoid-forming enzyme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1120e8b186ab8ef24be4b480d11a4f3d
http://europepmc.org/articles/PMC2192519

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Determination of the contribution of cysteinyl leukotrienes and leukotriene B4 in acute inflammatory responses using 5-lipoxygenase- and leukotriene A4 hydrolase-deficient mice

Autor: R S, Byrum, J L, Goulet, J N, Snouwaert, R J, Griffiths, B H, Koller

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(12)

Arachidonic acid metabolism by 5-lipoxygenase leads to production of the potent inflammatory mediators, leukotriene (LT) B4 and the cysteinyl LT. Relative synthesis of these subclasses of LT, each with different proinflammatory properties, depends on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f8a96e545cd869cc27b80a59c6a06627
https://pubmed.ncbi.nlm.nih.gov/10586081

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Deficiency of 5-lipoxygenase abolishes sex-related survival differences in MRL-lpr/lpr mice

Autor: J L, Goulet, R C, Griffiths, P, Ruiz, R F, Spurney, D S, Pisetsky, B H, Koller, T M, Coffman

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(1)

Leukotrienes, the 5-lipoxygenase (5LO) products of arachidonic acid metabolism, have many proinflammatory actions that have been implicated in the pathogenesis of a variety of inflammatory diseases. To investigate the role of LTs in autoimmune diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4b7a56783103c72df38a676f4ac86004
https://pubmed.ncbi.nlm.nih.gov/10384136

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Embryonic stem cell lines from MRL mice allow genetic modification in a murine model of autoimmune disease

Autor: J L, Goulet, C Y, Wang, B H, Koller

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 159(9)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c2dd7d948e71868dddd457cc48c8c47b
https://pubmed.ncbi.nlm.nih.gov/9379035

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Tourette syndrome: a psychoeducational presentation

Autor: D, Lagiewka-Cook, J L, Goulet, R, Wand, G, Shady

Publikováno v: Axone (Dartmouth, N.S.). 14(4)

Tourette Syndrome (TS) is a neurological disorder with onset prior to age 21. The wide range of difficulties associated with TS present significant barriers to both the positive school functioning of students with TS and the ability of their teachers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::87407fbb78b4d17a3c2d5b84c29ff483
https://pubmed.ncbi.nlm.nih.gov/8274388

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