Zobrazeno 1 - 10
of 44
pro vyhledávání: '"J L Coleman"'
Autor:
Sophie G. Kellaway, Sandeep Potluri, Peter Keane, Helen J. Blair, Luke Ames, Alice Worker, Paulynn S. Chin, Anetta Ptasinska, Polina K. Derevyanko, Assunta Adamo, Daniel J. L. Coleman, Naeem Khan, Salam A. Assi, Anja Krippner-Heidenreich, Manoj Raghavan, Peter N. Cockerill, Olaf Heidenreich, Constanze Bonifer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Acute Myeloid Leukemia (AML) is caused by multiple mutations which dysregulate growth and differentiation of myeloid cells. Cells adopt different gene regulatory networks specific to individual mutations, maintaining a rapidly proliferating
Externí odkaz:
https://doaj.org/article/d6aa9401fa5141ad9c390f2a12d3bb12
Autor:
Sarah L. Bevington, Remi Fiancette, Dominika W. Gajdasik, Peter Keane, Jake K. Soley, Claire M. Willis, Daniel J. L. Coleman, David R. Withers, Peter N. Cockerill
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
T cell immunological memory is established within days of an infection, but little is known about the in vivo changes in gene regulatory networks accounting for their ability to respond more efficiently to secondary infections. To decipher the timing
Externí odkaz:
https://doaj.org/article/2cd43fb377234afe9b4df748fcec3954
Autor:
Daniel J. L. Coleman, Remi Fiancette, Peter Keane, Jake K Soley, David R. Withers, Peter N. Cockerill, Claire Willis, Sarah L Bevington, Dominika W Gajdasik
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
T cell immunological memory is established within days of an infection, but little is known about the in vivo changes in gene regulatory networks accounting for their ability to respond more efficiently to secondary infections. To decipher the timing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b478363fb30a10669643d32e8a97d1
https://www.frontiersin.org/articles/10.3389/fimmu.2021.642807/full
https://www.frontiersin.org/articles/10.3389/fimmu.2021.642807/full
Autor:
Peter N. Cockerill, Phil Jenkin, Ash Uddin, Anetta Ptasinska, Samuel Clokie, Manoj Raghavan, Constanze Bonifer, Andrew D Beggs, Michael J. Griffiths, Stephen J. Richards, Salam A. Assi, Paulynn Suyin Chin, Pierre Cauchy, Anna Pickin, Sally R. James, Joaquin Zacarias-Cabeza, Maria Rosaria Imperato, Helen J. Blair, Olaf Heidenreich, Justin Loke, L. Niall Gilding, Ruud Delwel, Sandeep Potluri, Daniel J. L. Coleman
Publikováno v:
Nature genetics
Nature Genetics, 51(1), 151-+. Nature Publishing Group
Nature Genetics, 51(1), 151-+. Nature Publishing Group
Acute myeloid leukemia (AML) is a highly heterogeneous cancer associated with different patterns of gene expression determined by the nature of their DNA mutations. These mutations mostly act to deregulate gene expression by various mechanisms at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a71a848aface6f2a09595f2fe8354097
https://doi.org/10.1038/s41588-018-0270-1
https://doi.org/10.1038/s41588-018-0270-1
Autor:
Janice Ser Huay Lee, Peter A. Todd, Erik Meijaard, Wolfram Dressler, Susan Page, Benjamin P. Y.-H. Lee, Mary Rose C. Posa, Damayanti Buchori, S. T. Vo, Eleanor M. Slade, Zeehan Jaafar, Beria Leimona, J. L. Coleman, Madhu Rao, Alice C. Hughes, Matthew Linkie, Lian Pin Koh, Syed Ajijur Rahman, T. E. E. dela Cruz, P. Parolin, Tien Ming Lee, Xingli Giam, A. Olsson, Luke Gibson, James Reed, Daniel A. Friess, Edward L. Webb, Kwek Yan Chong, Anuj Jain, David Taylor, Luis R. Carrasco, Anthony J. Lynam, M. Leggett, Graham W. Prescott, Charles M. Francis, David Bickford, Alan D. Ziegler, Gopalasamy Reuben Clements, Puay Yok Tan, John S. Ascher, Daniel R. Richards, David Edwards, Danwei Huang, Ryan A. Chisholm, A. Cabanban, Enoka P. Kudavidanage, Robert Steinmetz, Vincent Nijman, Matthew Scott Luskin, Kelvin S.-H. Peh, Patrick Christie, Sorain J. Ramchunder
Publikováno v:
Biological Conservation
Biological Conservation, Elsevier, 2019, 234, pp.211-220. ⟨10.1016/j.biocon.2019.03.028⟩
Biological Conservation, Elsevier, 2019, 234, pp.211-220. ⟨10.1016/j.biocon.2019.03.028⟩
Southeast (SE) Asia holds high regional biodiversity and endemism levels but is also one of the world's most threatened regions. Local, regional and global threats could have severe consequences for the future survival of many species and the provisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bd301f4a8c3870d10504bb5a6e83072
https://hal.inrae.fr/hal-02626285
https://hal.inrae.fr/hal-02626285
The fusion oncoprotein CBFβ-SMMHC, expressed in leukemia cases with chromosome 16 inversion, drives leukemia development and maintenance by altering the activity of the transcription factor RUNX1. Here, we demonstrate that CBFβ-SMMHC maintains cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::162fe7248c555dd28302530ef98e02b7
https://europepmc.org/articles/PMC6182015/
https://europepmc.org/articles/PMC6182015/
Publikováno v:
Physical Modelling in Geotechnics ISBN: 9780429438660
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bfc063e17d5be17c84606bf25b9c5b2
https://doi.org/10.1201/9780429438660-39
https://doi.org/10.1201/9780429438660-39
Autor:
Giacomo Volpe, David S. Walton, David E. Grainger, Carl Ward, Pierre Cauchy, Daniel Blakemore, Daniel J. L. Coleman, Peter N. Cockerill, Paloma Garcia, Jon Frampton
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Growth Factor Independence 1 (GFI1) is a transcriptional repressor that plays a critical role during both myeloid and lymphoid haematopoietic lineage commitment. Several studies have demonstrated the involvement of GFI1 in haematological malignancies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::52307ea45ccd4fcbf16866bd2047d73d
http://europepmc.org/articles/PMC5593973
http://europepmc.org/articles/PMC5593973
Autor:
Peter N. Cockerill, Anetta Ptasinska, Daniel J. L. Coleman, Sandeep Potluri, Suyin Paulynn Chin, Salam A. Assi, Constanze Bonifer
Publikováno v:
Blood. 134:1232-1232
The gene encoding Wilms Tumor 1 (WT1) is recurrently upregulated in Acute Myeloid Leukemia (AML). WT1 transcript burden is associated with primary refractory disease and with relapse when there is detectable WT1 minimal residual disease (Lambert et a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d330d44a0ab03267c828d756c0bd391
https://doi.org/10.1182/blood-2019-122533
https://doi.org/10.1182/blood-2019-122533
Autor:
Christopher D. Allen, Olaf Heidenreich, David A. Fulton, Daniel J. L. Coleman, Marta Omedes Pujol
Publikováno v:
Journal of Controlled Release
Short interfering ribonucleic acids (siRNAs) offer a highly specific and selective form of therapy for diseases with a genetic component; however the poor pharmacokinetic properties of the molecule have impeded its development into a therapeutic for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7006dba8a84be56ae76e5ff387d47393
https://doi.org/10.1016/j.jconrel.2013.10.013
https://doi.org/10.1016/j.jconrel.2013.10.013