Characterization of lymphotoxin-alpha beta complexes on the surface of mouse lymphocytes

Autor: J L Browning, I D Sizing, P Lawton, P R Bourdon, P D Rennert, G R Majeau, C M Ambrose, C Hession, K Miatkowski, D A Griffiths, A Ngam-ek, W Meier, C D Benjamin, P S Hochman

Publikováno v: The Journal of Immunology. 159:3288-3298

The lymphotoxin-alpha beta complex (LT alpha beta) is found on the surface of activated lymphocytes and binds to a specific receptor called the LT beta receptor (LT beta R). In the mouse, signaling through this pathway is important for lymph node dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e92a2beb5716c3173d988b9487fe09b6
https://doi.org/10.4049/jimmunol.159.7.3288

Characterization of surface lymphotoxin forms. Use of specific monoclonal antibodies and soluble receptors

Autor: J L Browning, I Dougas, A Ngam-ek, P R Bourdon, B N Ehrenfels, K Miatkowski, M Zafari, A M Yampaglia, P Lawton, W Meier

Publikováno v: The Journal of Immunology. 154:33-46

Lymphotoxin (LT) is a cytokine related to TNF, found in human systems in both secreted and membrane bound forms. The well characterized secreted form is a trimer of a single protein, LT-alpha, whereas the surface form is composed of a complex between

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6cfd4d47998d499510462ff1c58caaa8
https://doi.org/10.4049/jimmunol.154.1.33

Attenuation of ceramide-induced apoptosis by diglyceride in human myeloid leukemia cells

Autor: J L Browning, W D Jarvis, Frank A. Fornari, Steven Grant, David A. Gewirtz, R N Kolesnick

Publikováno v: Journal of Biological Chemistry. 269:31685-31692

Prior studies demonstrated that increased intracellular availability of ceramide induces apoptotic DNA degradation and cell death in the human leukemia cell lines HL-60 and U937 (Jarvis, W. D., Kolesnick, R. N., Fornari, F. A., Traylor, R. S., Gewirt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::572e93396e961cbd9408fc34f12064e6
https://doi.org/10.1016/s0021-9258(18)31750-2

Lymphotoxin is expressed as a heteromeric complex with a distinct 33-kDa glycoprotein on the surface of an activated human T cell hybridoma

Autor: J L Browning, M J Androlewicz, Carl F. Ware

Publikováno v: Journal of Biological Chemistry. 267:2542-2547

We characterized the membrane-associated form of lymphotoxin (surface LT) on the activated II-23.D7 T cell hybridoma. Antibodies to rLT precipitated both surface LT and a distinct 33-kDa glycoprotein (p33). Because p33 and surface LT were antigenical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f54bc602177490e6ef927e4a9c3fa21
https://doi.org/10.1016/s0021-9258(18)45914-5

Effects of tumor necrosis factor and lymphotoxin on peripheral lymphoid tissue development

Autor: Sara A. Michie, Georg Kraal, Rachel Ettinger, Reina E. Mebius, W. Van Ewijk, S van Tuijl, Hugh O. McDevitt, J L Browning

Publikováno v: International Immunology, 10(6), 727-41. Oxford University Press
Ettinger, R, Mebius, R, Browning, J L, Michie, S A, van Tuijl, S, Kraal, G, van Ewijk, W & McDevitt, H O 1998, ' Effects of tumor necrosis factor and lymphotoxin on peripheral lymphoid tissue development ', International Immunology, vol. 10, no. 6, pp. 727-41 .
International Immunology, 10(5), 727-741. Oxford University Press

Previously, we have reported that neutralization of surface lymphotoxin (LT-alphabeta) in mice which expressed an LT-beta receptor-Fc fusion protein, driven by the cytomegalovirus promoter, resulted in an array of anatomic abnormalities. We now repor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb091df36a237d3a5f6eb1f5e91a2051
https://research.vumc.nl/en/publications/947e3548-0754-4ecf-9967-f57eb369d9e1