Zobrazeno 1 - 10 of 111 pro vyhledávání: '"J L Breslow"'
1
Akademický článek
Decreased HDL cholesterol levels but normal lipid absorption, growth, and feeding behavior in apolipoprotein A-IV knockout mice
Autor: P H Weinstock, C L Bisgaier, T Hayek, K Aalto-Setala, E Sehayek, L Wu, P Sheiffele, M Merkel, A D Essenburg, J L Breslow
Publikováno v: Journal of Lipid Research, Vol 38, Iss 9, Pp 1782-1794 (1997)
To determine the physiological role of apolipoprotein (apo) A-IV, knockout mice were created by gene targeting in embryonic stem cells. In apoA-IV knockout mice, plasma cholesterol and triglyceride levels were reduced 25% and 44%, respectively, compa
Externí odkaz: https://doaj.org/article/91ec9424a5374937b81f18952239cb5b
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2
Akademický článek
ApoA-I knockout mice: characterization of HDL metabolism in homozygotes and identification of a post-RNA mechanism of apoA-I up-regulation in heterozygotes
Autor: A S Plump, N Azrolan, H Odaka, L Wu, X Jiang, A Tall, S Eisenberg, J L Breslow
Publikováno v: Journal of Lipid Research, Vol 38, Iss 5, Pp 1033-1047 (1997)
The major high density lipoprotein (HDL) apolipoprotein, apoA-I, was knocked out by gene targeting in ES cells to provide a model for the study of HDL metabolism and its relationship to plasma and tissue cholesterol metabolism. HDL and non-HDL choles
Externí odkaz: https://doaj.org/article/17799a29125b40909132c8c289cada5b
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3
Akademický článek
Further characterization of the metabolic properties of triglyceride-rich lipoproteins from human and mouse apoC-III transgenic mice.
Autor: K Aalto-Setälä, P H Weinstock, C L Bisgaier, L Wu, J D Smith, J L Breslow
Publikováno v: Journal of Lipid Research, Vol 37, Iss 8, Pp 1802-1811 (1996)
We previously showed that human apoC-III expression in transgenic mice causes hypertriglyceridemia due to the accumulation of enlarged very low density lipoprotein (VLDL)-like particles, with increased triglycerides and apoC-III and decreased apoE. I
Externí odkaz: https://doaj.org/article/81252d14126a43da8c851a516888bcaa
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4
Akademický článek
Alternative polyadenylation of apolipoprotein B RNA is a major cause of B-48 protein formation in rat hepatoma cell lines transfected with human apoB-100 minigenes.
Autor: T Heinemann, S Metzger, E A Fisher, J L Breslow, L S Huang
Publikováno v: Journal of Lipid Research, Vol 35, Iss 12, Pp 2200-2211 (1994)
The human apoB gene encodes an mRNA of 14121 nucleotides. In liver the apoB gene products a full-length mature protein of 4,536 amino acids (B-100), whereas in the intestine this gene produces a truncated protein of 2,152 amino acids (B-48). B-48 res
Externí odkaz: https://doaj.org/article/4587869d54834b6d87541d0389af44d1
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5
Akademický článek
Transcriptional regulation of the apoC-III gene by insulin in diabetic mice: correlation with changes in plasma triglyceride levels.
Autor: M Chen, J L Breslow, W Li, T Leff
Publikováno v: Journal of Lipid Research, Vol 35, Iss 11, Pp 1918-1924 (1994)
Insulin-dependent diabetes mellitus (IDDM) is associated with elevated plasma triglyceride levels that normalize after insulin administration. The observation that overexpression of the apoC-III gene in transgenic mice can cause hypertriglyceridemia
Externí odkaz: https://doaj.org/article/c1310f9831e5407d815ea02201600534
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6
Akademický článek
Hypertriglyceridemic mice transgenic for the human apolipoprotein C-III gene are neither insulin resistant nor hyperinsulinemic.
Autor: G M Reaven, C E Mondon, Y D Chen, J L Breslow
Publikováno v: Journal of Lipid Research, Vol 35, Iss 5, Pp 820-824 (1994)
Plasma glucose and insulin concentrations and in vivo and in vitro estimates of insulin action were compared in hypertriglyceridemic apolipoprotein C-III transgenic mice (mean +/- SE triglyceride concentration = 11.8 +/- 0.9 mmol/l) and their normotr
Externí odkaz: https://doaj.org/article/d754c284d7654fbd913a2358e8c896b5
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7
Akademický článek
Intestinal expression of the human apoA-I gene in transgenic mice is controlled by a DNA region 3' to the gene in the promoter of the adjacent convergently transcribed apoC-III gene.
Autor: A Walsh, N Azrolan, K Wang, A Marcigliano, A O'Connell, J L Breslow
Publikováno v: Journal of Lipid Research, Vol 34, Iss 4, Pp 617-623 (1993)
The apoA-I gene in humans is principally expressed in liver and small intestine. Using transgenic mice, we previously showed that 256 bp of 5' flanking DNA was sufficient for liver expression, but as much as 5.5 kb of 5' and 4.0 kb of 3' DNA did not
Externí odkaz: https://doaj.org/article/cced0a0b7e454f7b9dadab97cdeaa8e9
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8
Akademický článek
Studies of familial type III hyperlipoproteinemia using as a genetic marker the apoE phenotype E2/2
Autor: J L Breslow, V I Zannis, T R SanGiacomo, J L Third, T Tracy, C J Glueck
Publikováno v: Journal of Lipid Research, Vol 23, Iss 8, Pp 1224-1235 (1982)
Clinical symptoms, lipoprotein patterns, and apoE phenotypes were determined in 17 individuals with type III hyperlipoproteinemia (type III HLP) and in their relatives and spouses. The apoE phenotype E2/2 occurred in 15 type III HLP probands (88%) an
Externí odkaz: https://doaj.org/article/0eb66cbcfb2f4629967a28b52ac66057
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10
Akademický článek
Isolation and characterization of cDNA clones corresponding to two different human apoC-III alleles.
Autor: S K Karathanasis, V I Zannis, J L Breslow
Publikováno v: Journal of Lipid Research, Vol 26, Iss 4, Pp 451-456 (1985)
We have recently reported that the human apolipoprotein A-I (apoA-I) and apolipoprotein C-III (apoC-III) genes are physically linked and that the presence of a DNA insertion in the apoA-I gene is correlated with apoA-I-apoC-III deficiency in patients
Externí odkaz: https://doaj.org/article/d9f981fffe8747eb85a32117ae22c113
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