USP22 regulates APL differentiation via PML-RARα stabilization and IFN repression

Autor: Lisa Kowald, Jens Roedig, Rebekka Karlowitz, Kristina Wagner, Sonja Smith, Thomas Juretschke, Petra Beli, Stefan Müller, Sjoerd J. L. van Wijk

Publikováno v: Cell Death Discovery, Vol 10, Iss 1, Pp 1-11 (2024)

Abstract Ubiquitin-specific peptidase 22 (USP22) is a deubiquitinating enzyme (DUB) that underlies tumorigenicity, proliferation, cell death and differentiation through deubiquitination of histone and non-histone targets. Ubiquitination determines st

Externí odkaz: https://doaj.org/article/0fc6c043461f4dadbb7ba5930e2dcbc7

USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING

Autor: Rebekka Karlowitz, Megan L. Stanifer, Jens Roedig, Geoffroy Andrieux, Denisa Bojkova, Marco Bechtel, Sonja Smith, Lisa Kowald, Ralf Schubert, Melanie Boerries, Jindrich Cinatl, Steeve Boulant, Sjoerd J. L. van Wijk

Publikováno v: Cell Death and Disease, Vol 13, Iss 8, Pp 1-14 (2022)

Abstract Pattern recognition receptors (PRRs) and interferons (IFNs) serve as essential antiviral defense against SARS-CoV-2, the causative agent of the COVID-19 pandemic. Type III IFNs (IFN-λ) exhibit cell-type specific and long-lasting functions i

Externí odkaz: https://doaj.org/article/e0cff6daeb78475a8d5002c6e431347e

ATM inhibition enhances Auranofin-induced oxidative stress and cell death in lung cell lines.

Autor: Vanessa Ehrenfeld, Jan R Heusel, Simone Fulda, Sjoerd J L van Wijk

Publikováno v: PLoS ONE, Vol 15, Iss 12, p e0244060 (2020)

Ataxia-Telangiectasia (A-T), a pleiotropic chromosomal breakage syndrome, is caused by the loss of the kinase Ataxia-telangiectasia mutated (ATM). ATM is not only involved in the response to DNA damage, but also in sensing and counteracting oxidative

Externí odkaz: https://doaj.org/article/f812e193065e4820b2f736613860119d

ATF4 links ER stress with reticulophagy in glioblastoma cells

Autor: Sjoerd J L van Wijk, Nina Meyer, Donat Kögel, Muriel Mari, Svenja Zielke, Laura Zein, Simon Kardo, Fulvio Reggiori, Adriana Covarrubias-Pinto, Alexandra Stolz, Maximilian N. Kinzler, Simone Fulda

Publikováno v: Autophagy
Zielke, S, Kardo, S, Zein, L, Mari, M, Covarrubias-Pinto, A, Kinzler, M N, Meyer, N, Stolz, A, Fulda, S, Reggiori, F, Kögel, D & van Wijk, S 2021, ' ATF4 links ER stress with reticulophagy in glioblastoma cells ', Autophagy, vol. 17, no. 9, pp. 2432-2448 . https://doi.org/10.1080/15548627.2020.1827780
Autophagy, 17(9), 2432-2448. Taylor & Francis Group

Selective degradation of the endoplasmic reticulum (ER; reticulophagy) is a type of autophagy involved in the removal of ER fragments. So far, amino acid starvation as well as ER stress have been described as inducers of reticulophagy, which in turn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b1111425976b5b52f58946e606b4062
https://hdl.handle.net/11370/f377bb88-271d-40e1-81eb-02e2614d6033

Zafirlukast Induces VHL- and HIF-2α-Dependent Oxidative Cell Death in 786-O Clear Cell Renal Carcinoma Cells

Autor: Christopher, Wolf, Sonja, Smith, Sjoerd J L, van Wijk

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 7; Pages: 3567

Mutations in the Von Hippel–Lindau (VHL) gene are the driving force in many forms of clear cell renal cell carcinoma (ccRCC) and promote hypoxia-inducible factor (HIF)-dependent tumor proliferation, metastasis and angiogenesis. Despite the progress

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bff6ef16010584c81f111c5bd415b62