Zobrazeno 1 - 10
of 84
pro vyhledávání: '"J L, Woolley"'
Publikováno v:
Journal of Travel Medicine. 6:S8-S12
Background: Safe and effective antimalarial drugs are needed for treatment and prophylaxis of malaria. The combination of atovaquone and proguanil hydrochloride is a new antimalarial drug combination that has recently become available in many countri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6211322ee780eefba32abedbd4fcc222
https://doi.org/10.1093/jtm/6.suppl.s8
https://doi.org/10.1093/jtm/6.suppl.s8
Publikováno v:
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. 25(5)
A survey was carried out of 145 pregnant women in the third trimester in pregnancy to assess motivators to stop tobacco smoking and assess women's knowledge of fetal and maternal risk of smoking. In addition, the survey was to assess the acceptabilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c31caea764b1d9f2a30b5410c8ba40
https://pubmed.ncbi.nlm.nih.gov/16183574
https://pubmed.ncbi.nlm.nih.gov/16183574
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(5)
P-Glycoprotein (Pgp) and cytochrome P450 3A (CYP3A) are important enzymes affecting the disposition of HIV protease inhibitors (HIV PIs). After multiple dosing experiments in rats, decreases in the plasma concentrations and area under plasma concentr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e905ae3c336680ce2212e4e8c9d110a4
https://pubmed.ncbi.nlm.nih.gov/11302944
https://pubmed.ncbi.nlm.nih.gov/11302944
Autor:
J W, Polli, J L, Jarrett, S D, Studenberg, J E, Humphreys, S W, Dennis, K R, Brouwer, J L, Woolley
Publikováno v:
Pharmaceutical research. 16(8)
To determine the role of P-glycoprotein (Pgp) on the CNS penetration of the HIV protease inhibitor (PI) amprenavir (141W94) and to test the hypothesis that co-administration of a second HIV PI (ritonavir) could enhance amprenavir's brain penetration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d2e3924f77f772bd3722531d81450063
https://pubmed.ncbi.nlm.nih.gov/10468021
https://pubmed.ncbi.nlm.nih.gov/10468021
Autor:
D. V. Deangelis, C. Thauvin-Eliopoulos, J. D. C. Yao, Robert C. Moellering, M L Grayson, J. L. Woolley, George M. Eliopoulos, L. Walton
Publikováno v:
Antimicrobial Agents and Chemotherapy. 34:1792-1794
To assess the potential efficacy of trimethoprim-sulfamethoxazole (TMP-SMX) against serious enterococcal infections, we used a rat enterococcal endocarditis model comparing TMP-SMX therapy (500 mg of TMP plus 2,500 mg of SMX per kg of body weight per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::256b92604dd3adedce39e86b839d6ec4
https://doi.org/10.1128/aac.34.9.1792
https://doi.org/10.1128/aac.34.9.1792
Publikováno v:
Biopharmaceuticsdrug disposition. 18(5)
1954U89, 1,3-diamino-7-(1-ethylpropyl)-8-methyl-7H-pyrrolo-(3, 2-f)quinazoline, is a potent, lipid-soluble inhibitor of dihydrofolate reductase. The pharmacokinetics and bioavailability of 1954U89 were examined in male beagle dogs and male CD rats. D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e79a7fcaad09de4a7cba5203782f8dfb
https://pubmed.ncbi.nlm.nih.gov/9210981
https://pubmed.ncbi.nlm.nih.gov/9210981
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 19(6)
The disposition of [14C]piritrexim ([14C]PTX) in male dogs after iv and po doses of 1.8 mg/kg was examined. After either route of administration, greater than 90% of the dose was recovered in the exreta within 72 hr; approximately 20% was recovered i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1e094600af807a12fd417ffdfb1b1489
https://pubmed.ncbi.nlm.nih.gov/1687022
https://pubmed.ncbi.nlm.nih.gov/1687022
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 19(3)
The disposition of [14C]piritrexim in male rats after iv (5 and 10 mg/kg) and po (5, 10, and 20 mg/kg) doses was studied. After an iv dose of 10 mg/kg, rats excreted an average of 57% of the dose in feces and 32% in urine; after a po dose of 10 mg/kg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c77004dcf3f0f5201d528ffa4d304227
https://pubmed.ncbi.nlm.nih.gov/1680625
https://pubmed.ncbi.nlm.nih.gov/1680625
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 19(2)
Disposition and metabolism of crisnatol (14C-labeled), a novel antitumor agent, was examined after po and iv administration to rats. After both routes of drug administration, there was rapid elimination of the administered radioactivity in the urine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6e9fb73818914c0860ea198ae942b4bb
https://pubmed.ncbi.nlm.nih.gov/1676660
https://pubmed.ncbi.nlm.nih.gov/1676660
Publikováno v:
Clinical Pharmacology & Therapeutics. 75:P87
GR270773 (773) is a novel phospholipid emulsion with endotoxin binding activity. Alterations in dietary lipids have been shown to alter P450 activity. We therefore examined 773′s effects on protein content and activity of selected hepatic P450 enzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afae20ac499fc0ea171e376fdaae58df
https://doi.org/10.1016/j.clpt.2003.11.333
https://doi.org/10.1016/j.clpt.2003.11.333