Výsledky vyhledávání

Mismatch repair deficiency and CpG island hypermethylation in sporadic colon adenocarcinomas

Autor: Z, Xiong, A H, Wu, C M, Bender, J L, Tsao, C, Blake, D, Shibata, P A, Jones, M C, Yu, R K, Ross, P W, Laird

Publikováno v: Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 10(7)

Many studies have documented CpG island hypermethylation in human colon adenocarcinomas. Several of these reports have additionally found such CpG island hypermethylation to be more extensive in tumors with a mismatch-repair deficiency, as revealed b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::05c6fa2d56b0922ed11a3ea0e82dc04c
https://pubmed.ncbi.nlm.nih.gov/11440966

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Extensive somatic microsatellite mutations in normal human tissue

Autor: S, Vilkki, J L, Tsao, A, Loukola, M, Pöyhönen, O, Vierimaa, R, Herva, L A, Aaltonen, D, Shibata

Publikováno v: Cancer research. 61(11)

Microsatellite (MS) instability occurs in tumors with DNA mismatch repair (MMR) deficiencies but is typically absent in adjacent normal tissue. However, MS mutations have been observed in normal tissues from rare individuals with congenital MMR defic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4d7ec5f22fbea9bf067a4169c863b26f
https://pubmed.ncbi.nlm.nih.gov/11389087

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Bladder cancer genotype stability during clinical progression

Autor: J L, Tsao, Y, Yatabe, I D, Markl, K, Hajyan, P A, Jones, D, Shibata

Publikováno v: Genes, chromosomescancer. 29(1)

Genomic instability is manifested by the accumulation of large numbers of mutations. The rate at which mutations accumulate has been difficult to estimate because serial comparisons are required. For further insight into how quickly mutations accumul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7eefd99ac7f94411056371d7919959fb
https://pubmed.ncbi.nlm.nih.gov/10918390

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Tracing cell fates in human colorectal tumors from somatic microsatellite mutations: evidence of adenomas with stem cell architecture

Autor: J L, Tsao, J, Zhang, R, Salovaara, Z H, Li, H J, Järvinen, J P, Mecklin, L A, Aaltonen, D, Shibata

Publikováno v: The American journal of pathology. 153(4)

Occult aspects of tumor proliferation are likely recorded genetically as their microsatellite (MS) loci become polymorphic. However, MS mutations generated by division may also be eliminated with death as noncoding MS loci lack selective value. There

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::134177e561f88204af8e4db751bc4f7a
https://pubmed.ncbi.nlm.nih.gov/9777950

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Enhanced intestinal adenomatous polyp formation in Pms2-/-;Min mice

Autor: S M, Baker, A C, Harris, J L, Tsao, T J, Flath, C E, Bronner, M, Gordon, D, Shibata, R M, Liskay

Publikováno v: Cancer research. 58(6)

Analysis of two human familial cancer syndromes, hereditary nonpolyposis colorectal cancer and familial adenomatous polyposis, indicates that mutations in either one of four DNA mismatch repair gene homologues or the adenomatous polyposis coli (APC)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::788f528290286a5645273fa4d6ade58c
https://pubmed.ncbi.nlm.nih.gov/9515784

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Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair

Autor: J. Reneker, Sean M. Baker, Binhai Zheng, J.-L. Tsao, A. C. Harris, M. Gordon, Allan Bradley, R. M. Liskay, Xiang Yao, Darryl Shibata, Bronner Ce, Norman Arnheim, Prolla Ta

Publikováno v: Nature genetics. 18(3)

Germline mutations in the human MSH2, MLH1, PMS2 and PMS1 DNA mismatch repair (MMR) gene homologues appear to be responsible for most cases of hereditary non-polyposis colorectal cancer (HNPCC; refs 1-5). An important role for DNA replication errors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7290323ab0cf1b4842a33b01bce2723
https://pubmed.ncbi.nlm.nih.gov/9500552

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Telomerase activity in normal and neoplastic breast

Autor: J l, Tsao, Y, Zhao, J, Lukas, X, Yang, A, Shah, M, Press, D, Shibata

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 3(4)

Telomerase activity is detected in the majority of human tumors and provides a mechanism to escape from proliferative limitations due to telomere loss. Similar to other studies, telomerase activity was detected with a modified telomeric repeat amplif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::493bb12dd89959b613f85737bf365a01
https://pubmed.ncbi.nlm.nih.gov/9815730

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Early mutational activation of the c-Ki-ras oncogene in endometrial carcinoma

Autor: B D, Duggan, J C, Felix, L I, Muderspach, J L, Tsao, D K, Shibata

Publikováno v: Cancer research. 54(6)

Endometrial carcinoma is theorized to arise from a series of somatic mutations which alter benign endometrium to progressively less differentiated histological lesions. One genetic alteration implicated in the carcinogenesis of endometrial cancer is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c53a7b8f48006601a3de6b2fcf4d49b5
https://pubmed.ncbi.nlm.nih.gov/8137266

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