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Estimation and reliability of molecular sequence alignments

Autor: J L, Thorne, G A, Churchill

Publikováno v: Biometrics. 51(1)

The problem of estimating the relatedness of a pair of biological sequences is addressed. A stochastic model of sequence evolution is described that allows insertion and deletion as well as replacement of amino acid residues (or substitution of nucle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c01c537a8815dddf451658da30b79f4f
https://pubmed.ncbi.nlm.nih.gov/7766767

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Two progenitor cells for human oogonia inferred from pedigree data and the X-inactivation imprinting model of the fragile-X syndrome

Autor: C D, Laird, M M, Lamb, J L, Thorne

Publikováno v: American journal of human genetics. 46(4)

Laird has proposed that the human fragile-X syndrome is caused by abnormal chromosome imprinting. The analysis presented here supports and extends this proposal. Using published pedigrees that include DNA polymorphism (RFLP) data, we establish that t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::724031fc3d80ce067d4868dab86f6c34
https://pubmed.ncbi.nlm.nih.gov/1969225

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